A5078458496- Advanced biosensing and bioanalysis techniques
- Quantum Dots Synthesis And Properties
- Electron Spin Resonance Studies
- RNA Interference and Gene Delivery
- Vitamin C and Antioxidants Research
- Hearing Loss and Rehabilitation
- Redox biology and oxidative stress
- DNA and Nucleic Acid Chemistry
- Lanthanide and Transition Metal Complexes
- Acute Ischemic Stroke Management
- Microbial Inactivation Methods
- Chalcogenide Semiconductor Thin Films
- Chronic Myeloid Leukemia Treatments
- Nanoplatforms for cancer theranostics
- Advanced MRI Techniques and Applications
- Mitochondrial Function and Pathology
- Synthesis and Characterization of Heterocyclic Compounds
- Toxin Mechanisms and Immunotoxins
- Hearing, Cochlea, Tinnitus, Genetics
- Silymarin and Mushroom Poisoning
- Nanocluster Synthesis and Applications
- Meta-analysis and systematic reviews
- Nanoparticle-Based Drug Delivery
- Synthesis and biological activity
- Eosinophilic Esophagitis
University of Exeter
2015-2025
Bulgarian Academy of Sciences
2014-2023
Institute of Biophysics and Biomedical Engineering
2014-2023
Trakia University
2014-2023
National Institutes for Quantum Science and Technology
2007-2022
University of British Columbia
2021
National Institute for Health Research
2016
Sofia University "St. Kliment Ohridski"
2013-2016
Medical University of Sofia
2002-2016
National Institute of Advanced Industrial Science and Technology
2002-2007
The present study describes a stabilization of single quantum dot (QD) micelles by hydrophobic silica precursors and an extension the layer to form shell around micelle. obtained product consists up 92% nanocrystals (CdSe, CdSe/ZnS, or CdSe/ZnSe/ZnS dots) in micelles, coated with shell. thickness could vary, starting from 3 4 nm. Increasing increases photoluminescent characteristics QDs aqueous solution. silica-shelled CdSe/ZnS QD possess high yield solution, controlled small size, sharp...
The present study examined the potential of quantum dot bioconjugates to sensitize cells UV irradiation and promote photodynamic activity classical photosensitizers such as trifluoperazine (TFPZ) sulfonated aluminum phthalocyanine (SALPC). Water-soluble CdSe nanocrystals were conjugated with anti-CD antibody known specificity leukemia cells. Quantum conjugates incubated cell line Jurkat ensure specific interaction surface. This was confirmed by fluorescent confocal microscopy. Furthermore,...
Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species (ROS) and alter redox-homeostasis cancer cells.It is widely accepted effect these chemotherapeutics due to induction oxidative stress ROS-mediated apoptosis in cancer.On the other hand, harmful side effects chemotherapy are also increased production ROS disruption normal cells tissues.This article describes mechanisms for triggering modulation through ROS-dependent...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTQuantum Dot-Based Western Blot Technology for Ultrasensitive Detection of Tracer ProteinsRumiana Bakalova, Zhivko Zhelev, Hideki Ohba, and Yoshinobu BabaView Author Information On-site Sensing Diagnosis Research Laboratory, AIST-Kyushu, 807-1 Shuku-machi, Tosu 841-0052, Japan, Department Applied Chemistry, Graduate School Engineering, Nagoya University, Nagoya, Japan Cite this: J. Am. Chem. Soc. 2005, 127, 26, 9328–9329Publication Date...
The present study describes a stabilization of single quantum dot (QD) micelles by "hydrophobic" silica precursor and an extension layer to form shell around the micelle using "amphiphilic" "hydrophilic" precursors. obtained product consists approximately 92% nanocrystals (CdSe, CdSe/ZnS, or CdSe/ZnSe/ZnS QDs) into micelles, coated with shell. thickness varies, starting from 3-4 nm. Increasing increases photoluminescence characteristics QDs in aqueous solution. silica-shelled CdSe/ZnS QD...
In the present study, we describe design and fabrication of quantum dot-conjugated hybridization probes their application to development a comparatively simple rapid procedure for selection highly effective small-interfering RNA (siRNA) sequences interference (RNAi) in mammalian cells, example, siRNAs with high accessibility affinity respective mRNA target. A single-stranded siRNA was conjugated dot used as probe. The target amplified presence Cy5-labeled nucleotides, Cy5−mRNA served sample....
Background Identification of permanent hearing impairment at the earliest possible age is crucial to maximise development speech and language. Universal newborn screening identifies majority 1 in 1000 children born with a impairment, but later onset can occur any time there no optimum for further screening. A universal non-standardised school entry (SES) programme place many parts UK its value questioned. Objectives To evaluate diagnostic accuracy tests cost-effectiveness SES UK. Design...
To identify which international health technology assessment (HTA) agencies are undertaking evaluations of medical tests, summarize commonalities and differences in methodological approach, highlight examples good practice.A review incorporating: systematic identification HTA guidance documents mentioning evaluation tests; key contributing organizations abstraction approaches to all essential steps; summary similarities between organizations; important emergent themes define the current...
In the present study, we describe synthesis of highly luminescent uncoated water-soluble CdSe quantum dots (QDs) possessing following characteristics: ∼2 nm in diameter, with very good size distribution (in 95% homodispersed) accompanied by a broad-band photoluminescent spectrum. The synthetic procedure is simple, conducted at room temperature, absence most popular coordinating ligands (as TOPO or HDA), and reproducible. obtained core QDs possessed comparatively long fluorescence half-life...
The present study describes a novel nonradioactive methodology for in vivo noninvasive, real-time imaging of blood−brain barrier (BBB) permeability conventional drugs, using nitroxyl radicals as spin-labels and magnetic resonance (MRI). Two TEMPO-labeled analogues (SLENU SLCNUgly) the anticancer drug lomustine [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea] were synthesized, substitution cyclohexyl part with radical. Nonmodified radical TEMPOL was used comparison. derivatives injected...
We report a new methodology for direct visualization of superoxide production in the dopaminergic area brain Parkinson's disease, based on redox cycle mito-TEMPO, blood-brain barrier-, cell-, and mitochondria-penetrating nitroxide derivative with scavenging properties T1 magnetic resonance imaging (MRI) contrast. The experiments were conducted healthy 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In mice, nitroxide-enhanced MRI signal was weak short-lived (half-life ∼ 40...
Abstract Purpose: The study aimed to clarify the dynamics of tissue redox activity (TRA) in cancer progression and assess importance this parameter for therapeutic strategies. Experimental Design: experiments were carried out on brain tissues neuroblastoma-bearing, glioma-bearing, healthy mice. TRA was visualized vivo by nitroxide-enhanced MRI anesthetized animals or vitro electron paramagnetic resonance spectroscopy isolated specimens. Two biochemical parameters analyzed parallel: total...