A5023283967- Tryptophan and brain disorders
- Gut microbiota and health
- Barrier Structure and Function Studies
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Optimism, Hope, and Well-being
- Neuroscience of respiration and sleep
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Neurological and metabolic disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- Childhood Cancer Survivors' Quality of Life
- Glycosylation and Glycoproteins Research
- Dietary Effects on Health
- Traumatic Brain Injury and Neurovascular Disturbances
Université Laval
2022-2025
<title>Abstract</title> Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage circulating inflammatory mediators in mood-regulating brain areas and establishment depressive behaviors. Conversely, neurovascular adaptations favoring resilience exposure preventive strategies them remain poorly understood. Here, we report that environmental enrichment dampens stress-induced endothelial tight junction protein Claudin-5 (Cldn5) along with anxiety-...
Blood–brain barrier (BBB) alterations contribute to stress vulnerability and the development of depressive behaviors. In contrast, neurovascular adaptations underlying resilience remain unclear. Here we report that high expression astrocytic cannabinoid receptor 1 (CB1) in nucleus accumbens (NAc) shell, particularly end-feet ensheathing blood vessels, is associated with during chronic social adult male mice. Viral-mediated overexpression Cnr1 astrocytes NAc shell results baseline anxiolytic...
Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in microbiota-gut-brain axis has been implicated MDD pathogenesis. Exposure chronic stress disrupts blood-brain barrier integrity; still, little known about intestinal function these conditions, particularly for small intestine, where absorption most foods and drugs takes place.
<title>Abstract</title> Major depressive disorder (MDD) is a leading cause of disease burden worldwide with low therapeutic efficacy. The blood-brain barrier (BBB) essential to maintain brain homeostasis and regulate drug delivery. Chronic social stress, MDD’s main environmental risk factor, associated neurovascular pathology in mice including loss BBB integrity mood-regulating regions sex-specific manner, which also observed individuals MDD. Pericytes ensheathe endothelial cells modulate...
Abstract Blood-brain barrier (BBB) alterations contribute to stress vulnerability and development of depressive behaviors. In contrast, neurovascular adaptations underlying resilience remain unexplored. Here, we report that high expression astrocytic cannabinoid receptor 1 (CB1) in the nucleus accumbens (NAc) shell, particularly endfeet ensheathing blood vessels, is associated with despite chronic social exposure. Viral-mediated overexpression Cnr1 astrocytes NAc shell has baseline...
Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage circulating inflammatory mediators in mood-regulating brain areas and establishment depressive behaviors. Conversely, neurovascular adaptations favoring resilience exposure remain undetermined. Here, we report that environmental enrichment dampens stress-induced endothelial tight junction protein Claudin-5 (Cldn5) along with anxiety- depression-like behaviors mice via an increase fibroblast growth...
Abstract Major depressive disorder (MDD) is the leading cause of disability worldwide. However, 30-50% patients are unresponsive to commonly prescribed antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in microbiota-gut-brain axis, bidirectional communications between central nervous system and gastrointestinal tract that modulated by gut microorganisms, has been implicated MDD pathogenesis. Exposure chronic stress disrupts blood-brain barrier integrity, still,...
Summary Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage circulating inflammatory mediators in mood-regulating brain areas and establishment depressive behaviors. Conversely, neurovascular adaptations favoring resilience exposure remain undetermined. Here, we report that environmental enrichment dampens stress-induced endothelial tight junction protein Claudin-5 (Cldn5) along with anxiety- depression-like behaviors mice via an increase fibroblast...