A5089045054- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Adrenal Hormones and Disorders
- Neuroendocrine regulation and behavior
- Viral Infectious Diseases and Gene Expression in Insects
- 3D Printing in Biomedical Research
- Receptor Mechanisms and Signaling
- Asthma and respiratory diseases
- Advanced Battery Materials and Technologies
- Bone Metabolism and Diseases
- GDF15 and Related Biomarkers
- Nanofabrication and Lithography Techniques
- Immunodeficiency and Autoimmune Disorders
- Advanced Battery Technologies Research
- Gut microbiota and health
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Childhood Cancer Survivors' Quality of Life
Futaba (Japan)
2017-2024
Shionogi (Japan)
2018-2024
Icahn School of Medicine at Mount Sinai
2019-2024
Allen Institute for Brain Science
2019-2023
Toyota Motor Corporation (Japan)
2018
The University of Tokyo
2007-2014
Tokyo University of Science
2007-2011
Abstract In humans, traumatic social experiences can contribute to psychiatric disorders 1 . It is suggested that trauma impairs brain reward function such behaviour no longer rewarding, leading severe avoidance 2,3 rodents, the chronic defeat stress (CSDS) model has been used understand neurobiology underlying susceptibility versus resilience following trauma, yet little known regarding its impact on 4,5 Here we show that, CSDS, a subset of male and female mice, termed susceptible (SUS),...
Abstract Psychosocial stress has profound effects on the body, including immune system and brain 1,2 . Although a large number of pre-clinical clinical studies have linked peripheral alterations to stress-related disorders such as major depressive disorder (MDD) 3 , underlying mechanisms are not well understood. Here we show that expression circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in serum humans with MDD stress-susceptible mice following...
Abstract It has recently become clear that signals mediated by members of the TNFR superfamily, including lymphotoxin-β receptor (LTβR), activator for NF-κB (RANK), and CD40, play essential roles in organizing integrity medullary thymic epithelial cells (mTECs) required establishment self-tolerance. However, details mechanism responsible unique cooperative action individual multiple superfamily during mTEC differentiation still remain enigmatic. In this study, we show LTβR signal upregulates...
Medullary thymic epithelial cells (mTECs) expressing the autoimmune regulator AIRE and various tissue-specific antigens (TSAs) are critical for preventing onset of autoimmunity may attenuate tumor immunity. However, molecular mechanisms controlling mTEC development remain elusive. Here, we describe roles transcription factor Spi-B in development. is rapidly up-regulated by receptor activator NF-κB ligand (RANKL) cytokine signaling, which triggers differentiation, turn up-regulates CD80,...
Clinical studies have revealed a high comorbidity between autoimmune diseases and psychiatric disorders, including major depressive disorder (MDD). However, the mechanisms connecting autoimmunity depression remain unclear. Here, we aim to identify processes by which stress impacts adaptive immune system implications of such responses depression. To examine this relationship, analyzed antibody in chronic social defeat (CSDS) model mice, clinical samples from patients with MDD. We show that...
Regulatory T cells (Tregs), a subset of CD4(+) helper cells, are crucial for immunological self-tolerance. Defect in development or function Tregs results autoimmune disease human and mice. Whereas it is known that mainly develop the thymus, molecular mechanism underlying Treg not fully understood. TRAF6-deficient mice showed severe defect thymus. In vitro fetal thymic organ culture experiments indicated ascribed to absence TRAF6 cells. Moreover, mixed liver transfer revealed Foxp3(+)...
Abstract Signal transduction pathways regulating NF-κB activation essential for microenvironment formation in secondary lymphoid organs remain to be determined. We investigated the effect of a deficiency TNFR-associated factor 6 (TRAF6), which activates classical pathway, splenic formation. Two-week-old TRAF6-deficient mice showed severe defects B cell follicle and marginal zone formation, similar mutant defective lymphotoxin (Lt) β receptor (LtβR) signal induction nonclassical activation....
Tumor necrosis factor receptor–associated 6 (TRAF6) plays a critical role in establishing both innate and acquired immune responses by mediating signals from the TNF superfamily, TLR/IL-1R family, T-cell receptor. Here, we report previously unidentified function of TRAF6 IL-2 signaling. CD3/CD28 stimulation-induced proliferation Il2 mRNA expression Traf6−/−CD4+ T cells were dramatically enhanced. This enhancement is likely due to hyperactive signaling, which activation Jak1-Erk pathway was...
Abstract Chronic stress induces changes in the periphery and central nervous system (CNS) that contribute to neuropathology behavioral abnormalities associated with psychiatric disorders. In this study, we examined impact of peripheral inflammation during chronic social defeat (CSDS) female mice. Compared male mice, found mice exhibited heightened inflammatory response identified C-C motif chemokine ligand 5 (CCL5), as a stress-susceptibility marker females. Blocking CCL5 signaling promoted...
Abstract Chronic stress underlies the etiology of both major depressive disorder (MDD) and irritable bowel syndrome (IBS), two highly prevalent debilitating conditions with high rates co-morbidity. However, it is not fully understood how brain gut bi-directionally communicate during to impact intestinal homeostasis stress-relevant behaviours. Using chronic social defeat (CSDS) model, we find that stressed mice display greater permeability circulating levels endotoxin lipopolysaccharide (LPS)...
Vaccines that efficiently target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent for disease (COVID-19), are best means controlling viral spread. This study evaluated efficacy of COVID-19 vaccine S-268019-b, which comprises recombinant full-length SARS-CoV-2 spike protein S-910823 (antigen) and A-910823 (adjuvant). In addition to eliciting both Th1-type Th2-type cellular immune responses, two doses plus induced anti-spike IgG antibodies neutralizing...
In this study, electron irradiation effects on lithium peroxide (Li2O2), which is an important discharge product of Li–air (or Li–O2) batteries, were investigated using selected-area diffraction (SAED) and high-energy resolution energy-loss spectroscopy (EELS). The results obtained show that Li2O2 to Li2O transformation occurs with 80 300 keV incident electrons under high dose rates at 20 −183 °C. rate for was 1/5 the taking place We also present a series EELS spectra can be used as...
Alzheimer's disease (AD) is a common form of dementia. Although the causal mechanisms AD are not fully understood, intracerebral accumulation amyloid beta (Aβ) and tau aggregates seems to play an important role in development. Therefore, numerous experimental clinical studies targeting Aβ proteins have been performed. However, these treatments achieved good results. Additionally, recent findings indicated that immune abnormalities contribute pathogenesis AD. Several immune- microglia-related...
Abstract Psychosocial stress has profound effects on the body, including peripheral immune system and brain1,2. Although a large number of pre-clinical clinical studies have linked alterations to stress-related disorders such as major depressive disorder (MDD)3,4,5, underlying mechanisms are not well understood. Here we show that myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is elevated in serum subjects with MDD stress-susceptible (SUS) mice following chronic social...
Abstract Clinical studies have revealed a high comorbidity between autoimmune and psychiatric disorders, including major depressive disorder (MDD). However, the mechanisms connecting autoimmunity depression remain unclear. Here, we aim to identify processes linking adaptive immune abnormalities depression. To examine this relationship, analyzed antibody responses in chronic social defeat stress (CSDS) model mice, clinical samples from patients with MDD. We show that socially stressed mice...