A5012517247- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Histone Deacetylase Inhibitors Research
- Marine Sponges and Natural Products
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Traumatic Brain Injury and Neurovascular Disturbances
- Mitochondrial Function and Pathology
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Mass Spectrometry Techniques and Applications
- Crystallography and molecular interactions
- Advanced Proteomics Techniques and Applications
- Microbial Natural Products and Biosynthesis
- Exercise and Physiological Responses
- Prostate Cancer Treatment and Research
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Synthesis and Biological Activity
- Protein Degradation and Inhibitors
- X-ray Diffraction in Crystallography
- Semiconductor materials and interfaces
- Alcohol Consumption and Health Effects
Georgia Institute of Technology
2015-2025
Bioengineering Center
2025
BioScience Laboratories (United States)
2024
Stanford Medicine
2024
Parker Hannifin (United States)
2024
Technological University Dublin
2024
Atlanta Technical College
2022-2023
Stanford University
2020
Southeast TechInventures (United States)
2014
Duke University
2014
Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood
Phosphorylation of the nucleosides adenosine and uridine by simple mixing mild heating aqueous solutions organic compounds with synthetic analogs meteoritic mineral schreibersite, (Fe,Ni)3P under slightly basic conditions (pH ~9) is reported. These results suggest a potential role for phosphorus in origin development early life.
A challenge facing metabolomics in the analysis of large human cohorts is cross-laboratory comparability quantitative measurements. In this study, 14 laboratories analyzed various blood specimens using a common experimental protocol provided with Biocrates AbsoluteIDQ p400HR kit, to quantify up 408 metabolites. The included plasma and serum from male female donors, mouse rat plasma, as well NIST SRM 1950 reference plasma. metabolite classes covered range polar (e.g., amino acids biogenic...
Abstract Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) sex on its molecular landscape not fully established. Utilizing an integrative multi-omics approach, leveraging data generated by Molecular Transducers Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in scWAT sedentary rats response this to ExT. Specifically, females displays -omic...
Regular exercise has many physical and brain health benefits, yet the molecular mechanisms mediating effects across tissues remain poorly understood. Here we analyzed 400 high-quality DNA methylation, ATAC-seq, RNA-seq datasets from eight control endurance exercise-trained (EET) rats. Integration of baseline mapped gene location dependence epigenetic features identified differing regulatory landscapes in each tissue. The transcriptional responses to 8 weeks EET showed little overlap...
High performance mass spectrometry was employed to interrogate the serum metabolome of early-stage ovarian cancer (OC) patients and age-matched control women. The resulting spectral features were used establish a linear support vector machine (SVM) model sixteen diagnostic metabolites that are able identify OC with 100% accuracy in our patient cohort. results provide evidence for importance lipid fatty acid metabolism serve as foundation clinically significant test.
Significance Chemical cues are essential to marine life, particularly for detecting predators. Despite decades of research, almost nothing is known the molecular nature these waterborne cues. This prevents us from assessing environmental variation and impacts understanding manipulating predator–prey signaling pathways. Leveraging natural chemical in urine a predatory crab using metabolomics, profiles crabs fed different diets were revealed be predictive their fear-inducing potency. pattern...
While regular physical activity is a cornerstone of health, wellness, and vitality, the impact endurance exercise training on molecular signaling within across tissues remains to be delineated. The Molecular Transducers Physical Activity Consortium (MoTrPAC) was established characterize networks underlying adaptive response exercise. Here, we describe studies undertaken by Preclinical Animal Sites Studies component MoTrPAC, in which sought develop implement standardized protocol large cohort...
Liquid-chromatography mass spectrometry is commonly used to identify and quantify metabolites from biological samples gain insight into human physiology pathology. Metabolites their abundance in are labile sensitive variations collection conditions, handling processing. Variations sample could influence metabolite levels ways not related biology, ultimately leading the misinterpretation of results. For example, anticoagulants preservatives modulate enzyme activity oxidization. Temperature...
Renal cell carcinoma (RCC) is diagnosed through expensive cross-sectional imaging, frequently followed by renal mass biopsy, which not only invasive but also prone to sampling errors. Hence, there a critical need for noninvasive diagnostic assay. RCC exhibits altered cellular metabolism combined with the close proximity of tumor(s) urine in kidney, suggesting that metabolomic profiling an excellent choice assay development. Here, we acquired liquid chromatography-mass spectrometry (LC-MS)...
The dismally low survival rate of ovarian cancer patients diagnosed with high-grade serous carcinoma (HGSC) emphasizes the lack effective screening strategies. One major obstacle is limited knowledge underlying mechanisms HGSC pathogenesis at very early stages. Here, we present first 10-month time-resolved serum metabolic profile a triple mutant (TKO) mouse model, along spatial lipidome its entire reproductive system. A high-coverage liquid chromatography mass spectrometry-based metabolomics...
Traumatic brain injury (TBI) is a major health concern in the United States and globally, contributing to disability long-term neurological problems. Lipid dysregulation after TBI underexplored, better understanding of lipid turnover degradation could point novel biomarker candidates therapeutic targets. Here, we investigated overlapping lipidome changes blood using data-driven discovery approach understand alterations serum compartments acutely following mild (mTBI) potential efflux lipids...
Traumatic brain injury (TBI) is a significant source of disability in the United States and around world may lead to long-lasting cognitive deficits decreased quality life for patients across severities. Following primary phase, TBI characterized by complex secondary cascades that involve altered homeostasis metabolism, faulty signaling, neuroinflammation, lipid dysfunction. The objectives present study were (1) assess potential correlations between lipidome cytokine changes after...
Distinguishing ovarian cancer from other gynecological malignancies is crucial for patient survival yet hindered by non-specific symptoms and limited understanding of pathogenesis. Accumulating evidence suggests a link between deregulated lipid metabolism. Most studies have small sample sizes, especially early-stage cases, lack racial/ethnic diversity, necessitating more inclusive research improved diagnosis prevention.
Traumatic brain injury (TBI) is a global public health problem with 50–60 million incidents per year, most of which are considered mild (mTBI) and many these repetitive (rmTBI). Despite their massive implications, the pathologies mTBI rmTBI not fully understood, paucity information on lipid dysregulation following event(s). To gain more insight pathology, non-targeted spatial lipidomics workflow utilizing high resolution mass spectrometry imaging was developed to map region-specific...
Newborn screening (NBS) is one of the United States' largest, most successful preventative public health initiatives, improving outcomes for newborns with inborn errors metabolism. Most disorders on Recommended Uniform Screening Panel are screened using triple-quadrupole mass spectrometry and flow injection analysis. While these methods sensitive well suited high-throughput quantitative applications, breadth measured analytes limited to a relatively small number biomarkers, which often have...
Technological advances in mass spectrometry (MS), liquid chromatography (LC) separations, nuclear magnetic resonance (NMR) spectroscopy, and big data analytics have made possible studying metabolism at an "omics" or systems level. Here, we applied a multiplatform (NMR + LC–MS) metabolomics approach to the study of preoperative metabolic alterations associated with prostate cancer recurrence. Thus far, predicting which patients will recur even after radical prostatectomy has not been...
Crohn's disease (CD) is a chronic inflammatory of the gastrointestinal tract. A clear gap in our existing CD diagnostics and current management approaches lack highly specific biomarkers that can be used to streamline or personalize management. Comprehensive profiling metabolites holds promise; however, these high-dimensional profiles need reduced have relevance context CD. Machine learning are optimally suited bridge this knowledge by contextualizing metabolic alterations using genome-scale...
The realization of blue light-emitting optoelectronic devices has attracted much attenion. Here the leading candidates (ZnSe, GaN, SiC, organic polymers) are examined and research towards improvement zinc selenide in particular is reviewed. Deposition methods, precursors, p-type dopants all discussed. Figure shows a p–n junction after equilibration.
TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate immune responses to particle-delivered MPLA CpG.
Marine sponge holobionts are prolific sources of natural products. One the most geographically widespread classes sponge-derived products is bromotyrosine alkaloids. A distinguishing feature alkaloids that they present in phylogenetically disparate sponges. In this study, using specimens collected from Guam, Solomon Islands, Florida Keys, and Puerto Rico, we queried whether presence potentiates metabolomic microbiome conservation among distant different marine multi-omic characterization...
Traumatic brain injury (TBI) poses a major health challenge, with tens of millions new cases reported globally every year. Brain damage resulting from TBI can vary significantly due to factors including severity, mechanism and exposure repeated events. Therefore, there is need for robust blood biomarkers. Serum Sprague Dawley rats was collected at several timepoints within 24 h mild single or repeat closed head impacts. samples were analyzed via ultra-high-performance liquid...
High-grade serous carcinoma (HGSC) is the most common and deadliest form of ovarian cancer. Yet it largely asymptomatic in its initial stages. Studying origin early progression this disease thus critical identifying markers for detection screening purposes. Tissue-based mass spectrometry imaging (MSI) can be employed as an unbiased way examining localized metabolic changes between healthy cancerous tissue directly, at onset disease. In study, we describe MSI results from Dicer-Pten...
Abstract Regular exercise promotes whole-body health and prevents disease, yet the underlying molecular mechanisms throughout a whole organism are incompletely understood. Here, Molecular Transducers of Physical Activity Consortium (MoTrPAC) profiled temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome, immunome in blood, plasma, 18 solid tissues Rattus norvegicus over 8 weeks endurance training. The resulting data compendium...