A5077469767- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Nanopore and Nanochannel Transport Studies
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Nanoparticles: synthesis and applications
- Characterization and Applications of Magnetic Nanoparticles
- Gold and Silver Nanoparticles Synthesis and Applications
- Inflammasome and immune disorders
- Chemical Reactions and Isotopes
- Advanced biosensing and bioanalysis techniques
- Microtubule and mitosis dynamics
- Advanced Electron Microscopy Techniques and Applications
- Cancer Cells and Metastasis
- Pneumonia and Respiratory Infections
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Inhalation and Respiratory Drug Delivery
- Cellular Mechanics and Interactions
- Insects and Parasite Interactions
Case Western Reserve University
2011-2023
Texas Children's Hospital
2023
Baylor College of Medicine
2023
University Hospitals Cleveland Medical Center
2023
The Wallace H. Coulter Department of Biomedical Engineering
2016-2022
Georgia Institute of Technology
2015-2022
Institute of Technology of Cambodia
2020
University of Pennsylvania
2011
Leeds General Infirmary
1974
Public Health Department
1974
In the recent past, remarkable advances in nanotechnology have generated nanoparticles of different shapes and sizes, which been shown to exhibit unique properties suitable for biomedical applications such as cancer therapy imaging. Obviously, all are not made equal. This becomes evident when we consider their transport behavior under blood flow microcirculation. this work, evaluated effect critical physical characteristics particle shape, size density on a nanoparticle's tendency marginate...
While nanoparticles maximize the amount of chemotherapeutic drug in tumors relative to normal tissues, nanoparticle-based drugs are not accessible majority cancer cells because display patchy, near-perivascular accumulation tumors. To overcome limitations current their molecular or nanoparticle form, we developed a based on multicomponent nanochains deliver throughout tumor while reducing off-target delivery. The is composed three magnetic nanospheres and one doxorubicin-loaded liposome...
A trial of the effects measures designed to reduce exposure house-dust mites was performed on 14 children with mite-sensitive asthma. These reduced mite infestation beds and were associated clinical improvement asthmatic symptoms. Immunological studies revealed a tendency for levels total serum IgE fall during course trial, but no such changes apparent in anti-mite specific IgE. Possible reasons this discrepancy are discussed. The conclusion study is that use plastic mattress cover other...
While the enhanced permeability and retention effect may promote preferential accumulation of nanoparticles into well-vascularized primary tumors, it is ineffective in case metastases hidden within a large population normal cells. Due to their small size, high dispersion organs, low vascularization, metastatic tumors are less accessible targeted nanoparticles. To tackle these challenges, we designed nanoparticle for vascular targeting based on an αvβ3 integrin-targeted nanochain particle...
Glioblastoma multiforme is generally recalcitrant to current surgical and local radiotherapeutic approaches. Moreover, systemic chemotherapeutic approaches are impeded by the blood-tumor barrier. To circumvent limitations in latter area, we developed a multicomponent, chain-like nanoparticle that can penetrate brain tumors, composed of three iron oxide nanospheres one drug-loaded liposome linked chemically into linear assembly. Unlike traditional small-molecule drugs or spherical...
Tumors present numerous biobarriers to the successful delivery of nanoparticles. Decreased blood flow and high interstitial pressure in tumors dictate degree resistance extravasation To understand how a nanoparticle can overcome these biobarriers, we developed multimodal vivo imaging methodology, which enabled noninvasive measurement microvascular parameters deposition nanoparticles at microscopic scale. monitor spatiotemporal progression tumor vasculature its vascular permeability...
Monoclonal antibodies (mAb) have had a transformative impact on treating cancers and immune disorders. However, their use is limited by high development time monetary cost, manufacturing complexities, suboptimal pharmacokinetics, availability of disease-specific targets. To address some these challenges, we developed an entirely synthetic, multivalent, Janus nanotherapeutic platform, called Synthetic Nanoparticle Antibodies (SNAbs). SNAbs, with phage-display-identified cell-targeting ligands...
TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate immune responses to particle-delivered MPLA CpG.
There is a critical need for adjuvants that can safely elicit potent and durable T cell-based immunity to intracellular pathogens. Here, we report parenteral vaccination with carbomer-based adjuvant, Adjuplex (ADJ), stimulated robust CD8 T-cell responses subunit antigens afforded effective against respiratory challenge virus systemic bacterial infection. Studies understand the metabolic molecular basis ADJ’s effect on antigen cross-presentation by dendritic cells (DCs) revealed several...
Eliciting durable and protective T cell-mediated immunity in the respiratory mucosa remains a significant challenge. Polylactic-co-glycolic acid (PLGA)-based cationic pathogen-like particles (PLPs) loaded with TLR agonists mimic biophysical properties of microbes hence, simulate pathogen-pattern recognition receptor interactions to safely effectively stimulate innate immune responses. We generated micro particle PLPs TLR4 (glucopyranosyl lipid adjuvant, GLA) or TLR9 (CpG) agonists,...
Abstract Pathogens trigger activation of sensors the innate immune system that initiate molecular signaling enabling appropriate host defense programs. Although recognition pathogen-specific moieties or PAMPs by specialized receptors is well defined for a great number pathogens, mechanisms sensing pathogen-induced functional perturbations to cell remain poorly understood. Here we show disruption endosomal compartments in macrophages bacterium fully synthetic nanoparticles activates...
ABSTRACT Eliciting durable and protective T cell-mediated immunity in the respiratory mucosa remains a significant challenge. Polylactic-co-glycolic acid (PLGA)-based cationic pathogen-like particles (PLPs) loaded with TLR agonists mimic biophysical properties of microbes hence, simulate pathogen-pattern recognition receptor interactions to safely effectively stimulate innate immune responses. We generated micro particle PLPs TLR4 (glucopyranosyl lipid adjuvant, GLA) or TLR9 (CpG) agonists,...