A5081238267- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
- Gastrointestinal disorders and treatments
- Stroke Rehabilitation and Recovery
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Venous Thromboembolism Diagnosis and Management
- Vascular Malformations Diagnosis and Treatment
- Neurological and metabolic disorders
- Topic Modeling
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- RNA Interference and Gene Delivery
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Cancer Research and Treatments
- GaN-based semiconductor devices and materials
- Advanced Neural Network Applications
- Domain Adaptation and Few-Shot Learning
- T-cell and Retrovirus Studies
University of California, Irvine
2022-2025
UC Irvine Health
2025
University of California, Irvine Medical Center
2023
Massachusetts General Hospital
2015-2023
Harvard University
2015-2023
Baylor University
2006-2023
BluGlass (Australia)
2020-2023
Brigham and Women's Hospital
2021-2022
RTI International
2012-2022
University of California, San Diego
2018-2021
The baculovirus antiapoptotic protein p35 inhibited the proteolytic activity of human interleukin-1β converting enzyme (ICE) and three its homologs in enzymatic assays. Coexpression prevented autoproteolytic activation ICE from precursor form blocked ICE-induced apoptosis. Inhibition correlated with cleavage formation a stable ICE-p35 complex. ability to block apoptosis different pathways distantly related organisms suggests central conserved role for ICE-like proteases induction
Increased risk of neurological and psychiatric conditions after traumatic brain injury (TBI) is well-defined. However, cardiovascular endocrine comorbidity TBI in individuals without these comorbidities associations with post-TBI mortality have received little attention.To assess the incidence cardiovascular, endocrine, neurological, patients mild (mTBI) or moderate to severe (msTBI) analyze between mortality.This prospective longitudinal cohort study used hospital-based patient registry...
Age-related macular degeneration (AMD) is the leading cause of vision loss in elderly people over 60. The pathogenesis still unclear. It has been suggested that lysosomal stress may lead to drusen formation, a biomarker AMD. In this study, ARPE-19 cells were treated with chloroquine inhibit function.Chloroquine-treated demonstrate marked increase vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes lipid bodies LAMP-2 LipidTOX co-localization,...
One guanosine determines transcript fate Transcripts of the HIV-1 RNA genome can be either spliced and translated into viral proteins or packaged new virions as a progeny genome. The path taken depends on whether contains one at 5′ terminus (1G) rather than two three (2G 3G). Brown et al. used nuclear magnetic resonance spectroscopy to show that 1G transcripts adopt dimeric structure sequesters terminal cap required for translation splicing but exposes sites bind Gag protein, which recruits...
We study the most practical problem setup for evaluating adversarial robustness of a machine learning system with limited access: hard-label black-box attack setting generating examples, where model queries are allowed and only decision is provided to queried data input. Several algorithms have been proposed this but they typically require huge amount (>20,000) attacking one example. Among them, state-of-the-art approaches (Cheng et al., 2019) showed that can be modeled as an optimization...
In 1990, the National Institutes of Health (NIH) gave some organisms special status as designated model organisms. This article documents publication trends for these NIH-designated over past 40 years. We find that being a organism by NIH does not guarantee an increasing trend. An analysis and nonmodel included in GENETICS since 1960 reveal sharp decline number publications using yet no overall species diversity. suggest with successful records tend to share critical characteristics, such...
Summary The paper considers the use of level-of-effort (LOE) paradata to model non-response mechanism in surveys and adjust for bias, particularly bias that is missing not at random or non-ignorable. Our approach based on an unconditional maximum likelihood estimation (call-back) adapts extends prior work handle complexities are encountered large-scale field surveys. A test ‘missingness random’ assumption also proposed can be applied essentially any survey when LOE data available. adjustment...
The survival rates of 117 black and white patients treated by primary radiation for carcinoma the prostate at State University New York Health Science Center Brooklyn Kings County Hospital were analyzed according to age race. In addition, stage, grade, delay time in seeking medical attention analyzed. Survival was similar both young (<60 years) old (≥60 patients, with 45% 41% 5-year-survival rates, respectively. better 48% 5-year survival, than blacks, 35% survival. Black presented higher...
Abstract Introduction CONTACT is a national multidisciplinary study assessing the impact of COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). Methods The consecutive newly diagnosed PDAC from pre-COVID-19 cohort (07/01/2019-03/03/2019) were compared to during first wave UK (‘ COVID’ cohort, 16/03/2020-10/05/2020) , 12-month follow-up. Results Among 984 (pre-COVID: n = 483, COVID: 501), COVID was less likely receive staging...
This study investigated the relationship between trauma patients with TBI who did and not receive blood product transfusions incidence of venous thromboembolism (VTE) hypothesizing increase VTE risk. The Trauma Quality Improvement Program (TQIP) was queried from 2017 to 2021 identify adult (≥18 years-old) TBI. Patients receiving any within 4 h arrival were compared those not. Outcomes using bivariate analyses a multivariable logistic regression predictors VTE. Of 451,061 TBI, 32,276 (7.2%)...
Abstract The ‘KeyStrokes’ test (KS) was created as an online and computerized neuropsychological assessment to assess simple attention, processing speed, executive function. This pilot study aims show proof of concept the KS a assessment. Building on previous feasibility study, we assessed test's internal consistency correlations other neurocognitive assessments. Participants were recruited from clinical sample patients referred for standard evaluation asked perform several tests six...