A5004463017- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- COVID-19 and healthcare impacts
- Renal cell carcinoma treatment
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Appendicitis Diagnosis and Management
- Abdominal Trauma and Injuries
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Renal and related cancers
- Hernia repair and management
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Non-Invasive Vital Sign Monitoring
- Healthcare cost, quality, practices
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Phytase and its Applications
University Hospitals of North Midlands NHS Trust
2021-2024
Royal Stoke University Hospital
2019-2024
Musgrove Park Hospital
2023
University of Liverpool
2008-2014
Aintree University Hospital
2013
Liverpool Heart and Chest Hospital
2012
Southmead Hospital
1989
Hereditary pancreatitis (HP) is an autosomal dominant disease that displays the features of both acute and chronic pancreatitis. Mutations in human cationic trypsinogen (PRSS1) are associated with HP have provided some insight into pathogenesis pancreatitis, but mechanisms responsible for initiation not been elucidated role apoptosis necrosis has much debated. However, it generally accepted trypsinogen, prematurely activated within pancreatic acinar cell, a major process. Functional studies...
Abstract Introduction CONTACT is a national multidisciplinary study assessing the impact of COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). Methods The consecutive newly diagnosed PDAC from pre-COVID-19 cohort (07/01/2019-03/03/2019) were compared to during first wave UK (‘ COVID’ cohort, 16/03/2020-10/05/2020) , 12-month follow-up. Results Among 984 (pre-COVID: n = 483, COVID: 501), COVID was less likely receive staging...
Gallstone ileus is a complication of cholelithiasis resulting from fistula between the gallbladder and gastrointestinal tract. If sufficiently large, gallstone may lodge at narrowest part tract, usually terminal ileum, present with small bowel obstruction. Here authors unusual case an 82-year-old man who developed symptoms signs large obstruction due to untreated gallstone, measuring 7×4.5 cm, that fistulated into transvere colon subsequently impacted in sigmoid colon. An emergency...
Abstract COVID-19 pandemic has impacted health care globally with restructuring and prioritization of services. We prospectively analyzed 104 patients who underwent laparoscopic cholecystectomy during the peak in 2020 compared 217 from same period 2019. Emergency admissions constituted majority cases no statistical difference between both groups (p = 0.49). Most cholecystectomies were for biliary colic (41.3 vs. 35.5%) cholecystitis (37.5 43.8%) without any statistically 0.31 p 0.29,...
Abstract It’s well documented that obesity is a positive predictor of surgical morbidity and with increasing rates it becoming challenge for patients presenting related conditions such as acute cholecystitis. This study aims to assess the impact class on outcomes following laparoscopic cholecystectomy Methods A retrospective observational was performed undergoing emergency at UHNM from January 2022 2023. These were then stratified by their defined WHO; Healthy weight (BMI <25),...
Abstract Background Fluid balance in the management of acute pancreatitis (AP) is challenging and has been described as a “double-edged sword” whereby adequate fluids are required to counteract systemic hypovolaemia whilst excessive may exacerbate oedema. Given that data generated from randomised studies conflicting, optimal rate type fluid resuscitation for AP yet be determined. We aimed perform comprehensive meta-analysis all existing randomized controlled trials (RCTs) evaluate...
Abstract Background Stage I pancreatic cancer is defined as disease localised to the pancreas (T1-T2, N0, M0). Whilst landmark trials have demonstrated adjuvant chemotherapy (AC) improves survival in resectable disease, early stages comprise only 3-8% of cases. The benefit AC stage 1 yet be and there currently exists no data outlining use for United Kingdom (UK). We aimed perform a meta-analysis evaluating comparative outcomes resection with or without patients outline plans national...
Abstract Background Bile duct injury (BDI) in cholecystectomy is the most commonly recognised complication occurring 0.5-1.4% of cases and associated with significant morbidity mortality. Despite increasing number cholecystectomies falling bile injuries due to both surgical experience recognition issue, there appears be payouts by NHS England. We investigated trend claims, their underlying cause, stage procedure where they occurred past 20 years identify areas improvements could made, for...
Abstract Background Poor prognosis post-resection of pancreatic cancer is owed to a high rates recurrence (approximately 80%) despite complete surgical resection being achieved. The role re-resection in patients with recurrent unclear. Several studies have reported survival benefit repeat pancreatectomy for selected local the remnant pancreas after index pancreatectomy. We aimed conduct comprehensive systematic review and meta-analysis best available evidence evaluate outcomes completion...
Abstract Aims To evaluate comparative outcomes of pancreatic cancer resection with or without adjuvant chemotherapy in patients stage I cancer. Methods A systematic search MEDLINE, CENTRAL and Web Science bibliographic reference lists were conducted. All studies reporting for included their risk bias assessed using ROBINS-I tool. Survival analysed hazard ratio (HR) odds (OR) the time-to-event dichotomous outcomes, respectively. Results We 5 a total 4,037 resected 1 whom 2,374 had no...
Abstract Aims This retrospective observational study from a tertiary hepatobiliary centre sought to establish patterns in presentation and subsequent stage-dependent management survival outcomes of gallbladder cancer (GBC) over 20-year period. We also looked at recurrence rates utilisation chemotherapy the adjuvant palliative settings. Methods All cases GBC between 2001 2021 were identified through clincial coding locally maintained database. Relevant demographic, staging, information was...