About
Contact & Profiles
A5058675467
Research Areas
- RNA and protein synthesis mechanisms
- HIV Research and Treatment
- RNA Research and Splicing
Howard Hughes Medical Institute
2020
University of Maryland, Baltimore County
2020
One guanosine determines transcript fate Transcripts of the HIV-1 RNA genome can be either spliced and translated into viral proteins or packaged new virions as a progeny genome. The path taken depends on whether contains one at 5′ terminus (1G) rather than two three (2G 3G). Brown et al. used nuclear magnetic resonance spectroscopy to show that 1G transcripts adopt dimeric structure sequesters terminal cap required for translation splicing but exposes sites bind Gag protein, which recruits...
10.1126/science.aaz7959
article
EN
Science
2020-04-24
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