A5067986711- Body Composition Measurement Techniques
- Diet and metabolism studies
- Sports Performance and Training
- Obesity, Physical Activity, Diet
- Cardiovascular and exercise physiology
- Children's Physical and Motor Development
- Health and Lifestyle Studies
- Physical Activity and Health
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Dietary Effects on Health
- Sports injuries and prevention
- Thermoregulation and physiological responses
- Gut microbiota and health
- Physical Education and Training Studies
- Bariatric Surgery and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Gestational Diabetes Research and Management
- Exercise and Physiological Responses
- Cardiovascular Disease and Adiposity
- Sports and Physical Education Research
- Diabetes Treatment and Management
- Sports and Physical Education Studies
- Nutritional Studies and Diet
Translational Research Institute for Metabolism and Diabetes
2016-2025
AdventHealth Orlando
2020-2025
Translational Research Institute
2025
Orlando Health
2018-2024
Universidad de Málaga
2011-2023
University of North Carolina at Chapel Hill
2023
Stanford University
2023
Discovery Institute
2016-2020
Sanford Burnham Prebys Medical Discovery Institute
2016-2020
University of Lausanne
2018
The gut microbiome is emerging as a key modulator of human energy balance. Prior studies in humans lacked the environmental and dietary controls precision required to quantitatively evaluate contributions microbiome. Using Microbiome Enhancer Diet (MBD) designed deliver more substrates colon therefore modulate microbiome, we quantified microbial host balance controlled feeding study with randomized crossover design young, healthy, weight stable males females (NCT02939703). In metabolic ward...
The concept of mitochondrial dysfunction in ageing muscle is highly controversial. In addition, emerging evidence suggests that reduced oxidative capacity and efficiency underlie the aetiology mobility loss older adults. Here, we hypothesized studying well-phenotyped cohorts across a wide range physical activity would unveil function skeletal turn allow us to more clearly examine impact age per se on energetics. This also enabled define relationships between energetics lipid content with...
Over the last decades, world elderly population has increased exponentially and this tendency will continue during coming years; from 2000 to 2050, people over 60 double those 80 quadruple. Loss of independence occurs as age due mobility restrictions, frailty, decreased functional fitness cognitive abilities. Evidence shown that appropriate programs policies contribute keep older adults healthy independent time. The purpose chapter is report results our 3-year follow-up study designed...
Abstract Aim Healthy ageing interventions encompass regular exercise to prevent mitochondrial dysfunction, key player in sarcopenia pathogenesis. Mitochondrial biogenesis has been well documented, but remodelling response training is poorly understood. Here we investigated fusion, fission and mitophagy before after an intervention older adults. Methods Skeletal muscle biopsies were collected from 22 healthy sedentary men women 4 months of supervised training. Eight lifelong trained age‐...
ABSTRACT Purpose Cardiorespiratory fitness (CRF) measured by peak oxygen consumption (V̇O 2 ) declines with aging and correlates mortality morbidity. Cardiopulmonary exercise testing (CPET) is the criterion method to assess CRF, but its feasibility, validity, reliability in older adults are unclear. Our objective was design implement a dependable, safe, reliable CPET protocol adults. Methods V̇O CPET, performed using treadmill 875 ≥70 yr Study of Muscle, Mobility Aging (SOMMA). The included...
Methanogens are CH 4 -producing, H 2 -oxidizing archaea. Numerous studies have associated methanogens with obesity, but these results been inconsistent. One possible link to host metabolism may be tied the methanogens′ ability consume , thus reducing partial pressure and thermodynamically enhancing fermentation of sugars short-chain fatty acids (SCFA) that can absorb. Because research linking methanogenesis human is limited, our goal this exploratory analysis was investigate relationships...
Sprints with changes of direction (COD) have been traditionally associated performance in team sports. Jumping tests used as predictors COD; however, there are not too many studies analyzing how dominance affects the best turn. The purpose this study was to explore relationship between pertaining jumps (1 and 2 legs) COD (right left turns). Forty-two male students were selected at Faculty Physical Education (age: 20.1 ± 3.7 years; weight: 73.4 8.4 kg; body mass index: 23.1 2.6 kg·m(-2); fat...
ABSTRACT BACKGROUND Physical activity ( PA ) assessment by questionnaire is a cornerstone in the field of sport epidemiology studies. The Activity Questionnaire for Children PAQ ‐C) has been used widely to assess healthy school populations. aim this study was evaluate reliability and validity ‐C Spanish children using triaxial accelerometry as criterion. METHODS Eighty‐three (N = 46 boys, N 37 girls) (age 10.98 ± 1.17 years, body mass index 19.48 3.51 kg/m 2 were volunteers completed twice...
Considerable debate continues to surround the concept of mitochondrial dysfunction in aging muscle. We tested overall hypothesis that age per se does not influence function and markers mitochondria quality control, is, expression fusion, fission, autophagy proteins. also investigated cardiorespiratory fitness (VO2max) adiposity (body mass index) on these associations. Percutaneous biopsies vastus lateralis were obtained from sedentary young (n = 14, 24±3 years), middle-aged 24, 41±9 years)...
Exercise-induced perturbation of skeletal muscle metabolites is a probable mediator long-term health benefits in older adults. Although specific have been identified to be impacted by age, physical activity and exercise, the depth coverage metabolome still limited. Here, we investigated resting exercise-induced metabolite distribution from well-phenotyped adults who were active or sedentary, group young Percutaneous biopsies vastus lateralis obtained before, immediately after 3 h following...
Objective Roux‐en‐Y gastric bypass (RYGB) surgery can cause profound weight loss and improve overall cardiometabolic risk factors. Exercise (EX) training following RYGB provide additional improvements in insulin sensitivity ( S I ) cardiorespiratory fitness. However, it remains unknown whether a specific amount of EX post‐RYGB is required to achieve benefits. Methods We performed post hoc analysis participants who were randomized into either 6‐month structured program or health education...
Objective This study investigated the associations of both physical activity time (PA) and energy expenditure (EE) with weight fat mass (FM) loss in patients following Roux‐en‐Y gastric bypass (RYGB) surgery. Methods Ninety‐six nondiabetic were included this analysis. Post‐RYGB randomized one two treatments: A 6‐month exercise training program (RYBG+EX) or lifestyle educational classes (RYGB). Body composition was assessed by dual‐energy X‐ray absorptiometry computed tomography. Components...
Abstract Objective This study tested the hypothesis that treatment with glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping metabolic rate (SMR; kilocalories/day) than expected from loss of lean and fat mass (metabolic adaptation). Methods Phase 1b, double‐blind, randomized, placebo‐controlled was conducted at two centers inpatient wards. Thirty‐five healthy males females overweight obesity (age = 36.5 ± 7.1 years) were randomized...
The objective was to compare measures from dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA) and anthropometry with a reference four-compartment model estimate fat mass (FM) fat-free (FFM) changes in overweight obese women after weight-loss programme. Forty-eight (age 39.8 +/- 5.8 years; weight 79.2 11.8 kg; BMI 30.7 3.6 kg/m2) were studied an out-patient programme, before the 16-month intervention. Women attended weekly meetings for first 4 months, followed by...
Dias Quiterio, AL, Canero, EA, Baptista, FM, and Sardinha, LB. Skeletal mass in adolescent male athletes nonathletes: relationships with high-impact sports. J Strength Cond Res 25(12): 3439-3447, 2011-This study examined the between practice of different categories sports (high-impact vs. nonimpact) bone status investigated differences from an age-matched control group. A total 54 26 nonathletes were evaluated. Bone mineral density, content (BMC), area at whole-body, limbs, lumbar spine...
Colonic microorganisms have been linked to human health and disease, specifically metabolic disease states such as obesity, but causal relationships remain be established. Previous work demonstrated that interactions between the host's diet intestinal microbiome were associated with energy balance by affecting human's absorption, quantified metabolizable energy. We developed Digestion, Absorption Microbial Metabolism (DAMM) model, which explicitly accounts for contributions of colonic...
https://youtu.be/KAfCLUuf1XY INTRODUCTION The Molecular Transducers of Physical Activity Consortium (MoTrPAC) protocol includes collection cardiopulmonary exercise testing (CPET) data as a key clinical outcome. Due to the large volume and institutions involved in MoTrPAC, CPET Core Lab was created manage repository, evaluate quality, analyze metabolic events continuous like ventilatory thresholds (VT). METHODS All centers MoTrPAC conducted CPETs on cycle ergometers following individualized...
Abstract Background. Preclinical literature and behavioral human data suggest that diet profoundly impacts the gut microbiome energy absorption—a key determinant of balance. To determine whether these associations are causal, domiciled controlled feeding studies with precise measurements dietary intake balance needed. Metabolomics—a functional readout modulation—can help identify putative mechanisms mediating effects. We previously demonstrated a high-fiber, minimally processed Microbiome...
White adipose tissue (WAT) plays a significant role in whole-body energy homeostasis, and its excess typifies obesity. In addition to WAT quantity, perturbations the basic cellular processes of (i.e. quality) are also associated with obesity metabolic disease. Exercise training alleviates obesity; however, underlying molecular mechanisms that drive these adaptations not well described. Abdominal subcutaneous biopsies were collected after an acute bout exercise (1 day after) at baseline...
Background: Several studies have created and validated accelerometry cut-off points to categorize intensities of physical activity (PA); however, there is not specific in pregnant women. Pregnancy promotes physiological biomechanical changes that can modify quantitively the relationship between movement energy expenditure. The aim this study was develop validate for light moderate-vigorous PA (LPA MVPA respectively), at each trimester pregnancy. Methodology: 31 healthy women completed same...
Quiterio, AL, Silva, AM, Minderico, CS, Carnero, EA, Fields, DA, and Sardinha, LB. Total body water measurements in adolescent athletes: a comparison of six field methods with deuterium dilution. J Strength Cond Res 23(4): 1225-1237, 2009-Assessing hydration, that is, total (TBW) athletes should be part comprehensive training program. However, there are no specific to assess TBW young athletes. Moreover, the use traditional techniques developed healthy youths, based on 2-compartment model,...