A5077772199- Liver physiology and pathology
- Bariatric Surgery and Outcomes
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Gut microbiota and health
- Cardiovascular Function and Risk Factors
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Liver Disease and Transplantation
- Amoebic Infections and Treatments
- Inflammatory Bowel Disease
- Drug-Induced Hepatotoxicity and Protection
- Abdominal vascular conditions and treatments
- Organ Transplantation Techniques and Outcomes
- Epilepsy research and treatment
- Hernia repair and management
- Diverticular Disease and Complications
- Cardiovascular Health and Disease Prevention
- Urinary and Genital Oncology Studies
- Reproductive tract infections research
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Vascular anomalies and interventions
Stanford University
2018-2024
E-Da Hospital
2010-2022
Bridge University
2015-2022
I-Shou University
2013-2022
Cardiovascular Institute of the South
2021
Chung Shan Hospital
2020
National Taiwan University
2009-2018
National Taiwan University Hospital
2006-2016
International Data Group (Sweden)
2015
Directorate-General for Interpretation
2015
Dravet syndrome is a devastating genetic brain disorder caused by heterozygous loss-of-function mutation in the voltage-gated sodium channel gene SCN1A. There are currently no treatments, but upregulation of SCN1A healthy allele represents an appealing therapeutic strategy. In this study we identified novel, evolutionary conserved mechanism controlling expression that mediated antisense non-coding RNA (SCN1ANAT). Using oligonucleotide-based compounds (AntagoNATs) targeting SCN1ANAT were able...
Statin treatment reduces the risk of atherosclerotic cardiovascular disease but is associated with a modest increased type 2 diabetes, especially in those insulin resistance or prediabetes. Our objective was to determine physiological mechanism for diabetes risk.
The vaginal microbiome's composition varies among ethnicities. However, the evolutionary landscape of microbiome in multi-ethnic context remains understudied. We perform a systematic analysis 351 samples from 35 pregnant women, addition to two validation cohorts, totaling 462 90 women. Microbiome alpha diversity and community state dynamics show strong ethnic signatures. Lactobacillaceae have higher ratio non-synonymous synonymous polymorphism lower nucleotide than non-Lactobacillaceae all...
Mutation in CUL4B, which encodes a scaffold protein of the E3 ubiquitin ligase complex, has been found patients with X-linked mental retardation (XLMR). However, early deletion Cul4b mice causes prenatal lethality, frustrated attempts to characterize phenotypes vivo. In this report, we successfully rescued mutant by crossing female exons 4-5 were flanked loxP sequences Sox2-Cre male mice. Cul4b-deficient (Cul4b(Δ)/Y) mice, no CUL4B was detected any major organs, including brain. hippocampus,...
BackgroundWhether patients with inflammatory bowel disease (IBD) exhibit a higher risk of developing acute coronary syndrome (ACS) remains debatable.
Whether patients with diverticular diseases exhibit a higher risk of developing pyogenic liver abscess (PLA) remains inconclusive. From the inpatient claims in Taiwan's National Health Insurance Research Database, we identified 54,147 diagnosed diverticulosis 1998 to 2010 period and 216,588 controls without disorder. The 2 cohorts were matched by age, sex, admission year, followed up until end estimate PLA. Overall, incidence PLA was 2.44-fold diverticular-disease group than (11.5 vs 4.65...
Hepatic portal venous gas (HPVG) is a rare but potentially lethal condition, especially when it results from intestinal ischemia. Since the literatures regarding prognostic factors of HPVG are still scarce, we aimed to investigate risk factor perioperative mortality in this study.We analyzed data for patients with ischemia induced by chart review our hospital between 2000 and 2007. Factors associated were specifically analyzed.There 22 consecutive receiving definite bowel resection. 13 cases...
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression cholestatic livers. We evaluated NGF and its cognate receptors human livers with hepatolithiasis effects therapy on liver injury hepatic SIRT1 a bile duct ligation (BDL) mouse model. Histopathological molecular analyses showed that hepatocytes diseased expressed NGF, proNGF (a precursor NGF), TrkA p75NTR, whereas only p75NTR was upregulated hepatolithiasis, compared non-hepatolithiasis In...
The role of nerve growth factor (NGF) in liver injury induced by bile duct ligation (BDL) remains elusive. This study aimed to investigate the relationship between inflammation and hepatic NGF expression, explore possible upstream molecules up-regulating NGF, determine whether could protect hepatocytes from oxidative injury. Biochemical molecular detection showed that was up-regulated cholestatic livers plasma, well correlated with systemic inflammation. Conversely, immunosuppression reduced...
Green fluorescent protein (GFP) and its derivatives are the most widely used molecular reporters for live cell imagining. The development of organelle-specific fusion proteins improves labeling resolution to a higher level. Here we generate R26 dual reporter mouse, activated by Cre-mediated DNA recombination, target cells with chromatin-specific enhanced green fluorescence (EGFP) plasma membrane-anchored monomeric cherry (mCherry). This allows visualization mitotic events, shapes...
Apigenin, a flavone abundant in parsley and celery, is known to act on several CNS receptors, but its very poor water solubility (<0.001 mg/mL) impedes absorption vivo prevents clinical use. Herein, apigenin was directly conjugated with glycine, l-phenylalanine, l-lysine give the corresponding carbamate derivatives, all of which were much more soluble than itself (0.017, 0.018, 0.13 mg/mL, respectively). The Lys-apigenin 10 had temporary sedative effect mice within 5 min intraperitoneal...
Endotoxemia and/or systemic inflammation may lead to disturbances in the cardiac autonomic nervous system and consequent arrhythmia. The underlying mechanism remains unclear. Therefore, we investigated expression of nerve growth factor (NGF) its association with sympathovagal balance a rodent model self-limited peritonitis. Male Wistar rats were randomized into following groups: normal control, sham, gastric perforation (GP), GP treated methylprednisolone. Cardiac NGF, growth-associated...