A5030069710- PARP inhibition in cancer therapy
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Innovations in Medical Education
- Empathy and Medical Education
- Cancer Genomics and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Maternal Mental Health During Pregnancy and Postpartum
- Economic and Financial Impacts of Cancer
- Gynecological conditions and treatments
- Computational Drug Discovery Methods
- Urological Disorders and Treatments
- Long-Term Effects of COVID-19
- Advanced Breast Cancer Therapies
- Uterine Myomas and Treatments
- Cancer Research and Treatments
- Disaster Response and Management
- Urban Green Space and Health
- Colorectal Cancer Screening and Detection
- Gastroesophageal reflux and treatments
- Cancer Treatment and Pharmacology
- Abdominal vascular conditions and treatments
- Obesity, Physical Activity, Diet
- Venous Thromboembolism Diagnosis and Management
- Bariatric Surgery and Outcomes
Johns Hopkins University
2024
Sibley Memorial Hospital
2024
Sidney Kimmel Cancer Center
2024
University of Colorado Denver
2006-2024
The University of Texas MD Anderson Cancer Center
2016-2023
University of Colorado Anschutz Medical Campus
2023
King's College London
2023
Children's Hospital Colorado
2022
National Health and Medical Research Council
2021
University of Dundee
2021
•Lockdown and re-deployment due to the COVID-19 pandemic have caused significant disruption cancer diagnosis management.•A 3-month delay surgery across all stage 1–3 cancers is estimated cause >4700 attributable deaths per year in England.•The impact on life-years lost of 3–6-month for disease varies widely between tumour types.•Strategic prioritisation patients diagnostics has potential mitigate delays.•The resource-adjusted benefit avoiding management compares favourably with admission...
Sociodemographic identities, including race, culture, ethnicity, gender, and sexual orientation (race culture), are recognized as important determinants of health, with significant impacts on patients' health outcomes, but teaching medical students about this is challenging. The authors sought to identify areas for improvement in delivery critical content structural inequalities, disparities within a set virtual patient cases used by U.S. schools develop revision guidelines.A workgroup...
To evaluate the impact of faecal immunochemical testing (FIT) prioritisation to mitigate delays in colorectal cancer (CRC) urgent diagnostic (2-week-wait (2WW)) pathway consequent from COVID-19 pandemic.
Context: Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) decrease with aging are important androgen estrogen precursors in older adults. Declines DHEAS may contribute to physiological changes that sex hormone dependent. Objective: The aim was determine whether DHEA replacement increases bone mineral density (BMD) fat-free mass. Design, Setting, Participants: A randomized, double-blinded, controlled trial conducted at an academic research institution. Participants were 70 women men,...
Selinexor (KPT-330) is an oral agent that has been shown to inhibit the nuclear exporter XPO1. Given pressing need for novel therapies triple-negative breast cancer (TNBC), we sought determine antitumor effects of selinexor in vitro and vivo.Twenty-six cell lines different subtypes were treated with vitro. Cell proliferation assays used measure half-maximal inhibitory concentration (IC50) test combination chemotherapy. In vivo efficacy was tested both as a single therapy TNBC patient-derived...
ABSTRACT Background Cancer diagnostics and surgery have been disrupted by the response of healthcare services to COVID-19 pandemic. Progression cancers during delay will impact on patient long-term survival. Methods We generated per-day hazard ratios cancer progression from observational studies applied these age-specific, stage-specific survival for England 2013-2017. modelled per-patient three months six periods disruption one year two years. Using resource costing, we contextualise...
Abstract Several alterations in fibroblast growth factor receptor (FGFR) genes have been found breast cancer; however, they not well characterized as therapeutic targets. Futibatinib (TAS-120; Taiho) is a novel, selective, pan-FGFR inhibitor that inhibits FGFR1-4 at nanomolar concentrations. We sought to determine futibatinib’s efficacy cancer models. Nine patient–derived xenografts (PDXs) with various and expression levels were treated futibatinib. Antitumor was evaluated by change tumor...
Urban greenspace has consistently been argued to be of great importance the wellbeing, health, and daily lives residents users. This paper reports results from a study that combined visualisation public with environmental economics, aimed develop method by which realistic computer models sites could used within preference studies. As part methodology employed contingent rating establish values placed on specific sites, three-dimensional were produce visualisations particular conditions. Of...
SUMMARY Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We evaluated efficacy and safety azithromycin in hospitalised patients with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial, several possible treatments were compared usual care UK. Eligible consenting randomly allocated to either standard alone or plus 500 mg once daily by mouth intravenously 10 days until discharge (or one other...
The past decade has witnessed an upsurge in medical curriculum partnerships established across national boundaries to offer students at the foreign institution (host) a learning experience comparable that of exporting (home). However, since environments and healthcare contexts differ greatly between institutions, concerns have been raised literature about potential low quality delivery, inadequate preparation practice host country setting, culture shock for having study home curriculum.....
Perinatal mental health is recognized as a priority component of obstetrical care. patients often turn to their obstetrician for help with concerns they view them primary care provider. Unfortunately, obstetricians face challenges in providing adequate support due time constraints and limited expertise. Integrated behavioral offers collaborative cost-effective solution enhance patient clinician satisfaction. clinicians possess fundamental skills throughout the reproductive lifespan assist...