A5073033523- Advances in Oncology and Radiotherapy
- Renal function and acid-base balance
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Disaster Response and Management
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Burn Injury Management and Outcomes
- Airway Management and Intubation Techniques
- Trauma and Emergency Care Studies
- Family and Patient Care in Intensive Care Units
- Anesthesia and Sedative Agents
- Ion Transport and Channel Regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- COVID-19 and healthcare impacts
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Electrolyte and hormonal disorders
- Health Systems, Economic Evaluations, Quality of Life
- Restraint-Related Deaths
- Economic and Financial Impacts of Cancer
- Anesthesia and Neurotoxicity Research
Albert Einstein College of Medicine
2023
Boston Children's Hospital
2023
Royal Marsden Hospital
2017-2020
Royal Marsden NHS Foundation Trust
2020
Indiana University
2019
Health Affairs
2015-2018
Imperial College London
2006-2017
Chelsea and Westminster Hospital
2006-2016
Chelsea and Westminster Hospital NHS Foundation Trust
2008-2016
University College London
2008
•Lockdown and re-deployment due to the COVID-19 pandemic have caused significant disruption cancer diagnosis management.•A 3-month delay surgery across all stage 1–3 cancers is estimated cause >4700 attributable deaths per year in England.•The impact on life-years lost of 3–6-month for disease varies widely between tumour types.•Strategic prioritisation patients diagnostics has potential mitigate delays.•The resource-adjusted benefit avoiding management compares favourably with admission...
Post-transplantation lymphoproliferative disorder (PTLD) is a widely recognized and often catastrophic complication of organ transplantation. The incidence PTLD after lung transplantation ranges from 6.2 to 9.4% two-fold higher than that seen other organs. Primary Epstein-Barr virus (EBV) infection major risk factor for PTLD, but the in EBV seronegative (EBV-) patients seems vary with type transplant. goal this study was quantify PLTD based on pre-lung serostatus transplant patients. Pre-...
Tumor necrosis factor α-converting enzyme (TACE) is responsible for the shedding of cell surface TNF. Studies suggest that reactive oxygen species (ROS) mediate up-regulation TACE activity by direct oxidization or modification protein. However, these investigations have been largely based upon nonphysiological stimulation promonocytic lines which may respond and process differently from primary cells. Furthermore, investigators relied substrate as a surrogate quantification. We addressed...
The baseline value of the Bispectral Index (BIS) is 96–99 in awake state. Patients with Alzheimer's disease or vascular dementia may show an increase slow wave and a decrease fast activity electroencephalogram (EEG). BIS presumed to EEG slowing. We hypothesized that "awake" lower than normal elderly patients. studied 36 patients multiinfarct control aged >75 yr. Both groups were assessed Mini-Mental State Test. (version 3.4) was recorded from frontal derivation using Aspect A-2000 monitor....
Abstract Introduction Intensive care unit-acquired weakness (ICU-AW) is common in survivors of critical illness, resulting global and functional deficit. Although ICU-AW well described subjectively the literature, value objective measures has yet to be established. This project aimed evaluate construct validity Chelsea Critical Care Physical Assessment tool (CPAx) by analyzing association between CPAx scores hospital-discharge location, as a measure outcome. Methods The was integrated into...
ABSTRACT Background Cancer diagnostics and surgery have been disrupted by the response of healthcare services to COVID-19 pandemic. Progression cancers during delay will impact on patient long-term survival. Methods We generated per-day hazard ratios cancer progression from observational studies applied these age-specific, stage-specific survival for England 2013-2017. modelled per-patient three months six periods disruption one year two years. Using resource costing, we contextualise...
Microvesicles are cell-derived signaling particles emerging as important mediators and biomarkers of systemic inflammation, but their production in severe burn injury patients has not been described. In this pilot investigation, we measured circulating microvesicle levels following burns, with sepsis a comparator group. We hypothesized that vascular microvesicles elevated acutely burns injury, mirroring clinical severity due to the early onset prevalence inflammatory response syndrome (SIRS)...
Summary Current guidelines for intra‐operative fluid management recommend the use of increments in stroke volume following intravenous bolus administration as a guide to subsequent therapy. To study physiological premise this paradigm, we tested hypothesis that healthy, non‐starved volunteers would develop an increment their passive leg raise manoeuvre. Subjects were positioned supine and was measured by transthoracic echocardiography at baseline, 30 s, 1 min, 3 min 5 after manoeuvre 45 ° ....
The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. circadian clock comprises a canonical transcription-translation feedback loop (TTFL) strictly dependent on BMAL1 transcription factor. We report that rhythmically localizes to hippocampal synapses in manner its phosphorylation at Ser
DiagnosisCT, PET/CT and MRI brain: Stage IVB (T2b N3 M1) NSCLC EBUS: TTF1-positive adenocarcinoma
The acidic pH of lysosomes is critical for catabolism in eukaryotic cells and altered neurodegenerative disease including Alzheimer Parkinson. Recent reports using Drosophila mammalian cell culture systems have identified novel and, at first sight, conflicting roles the lysosomal associated membrane proteins (LAMPs) regulation endolysosomal system.
Objective To evaluate the efficacy of eLearning in widespread standardised teaching, distribution and implementation Chelsea Critical Care Physical Assessment (CPAx) tool—a validated tool to assess physical function critically ill patients. Design Prospective educational study. An module was developed through a conceptual framework, using four-stage technique for skills teaching teach clinicians how use CPAx. Example test video case studies CPAx assessments were embedded within module. The...
This is a review of the role palliative care with intensive patients. End-of-life challenges are explored such as identifying patients at end life on ICU and involving patients, families health professionals in decision-making. Ethical issues around withholding withdrawing treatment also discussed. Integration into practice recommended to support patient, family team during patient's end-of-life bereavement.