A5067189350- Mechanical Circulatory Support Devices
- Acute Kidney Injury Research
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Cardiac electrophysiology and arrhythmias
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Blood transfusion and management
- Cardiac Ischemia and Reperfusion
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Single-cell and spatial transcriptomics
- ECG Monitoring and Analysis
- Long-Term Effects of COVID-19
- Electrochemical Analysis and Applications
- Immune cells in cancer
- Erythropoietin and Anemia Treatment
- Extracellular vesicles in disease
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Anesthesia and Sedative Agents
- Photoacoustic and Ultrasonic Imaging
- Ultrasound in Clinical Applications
- Cardiac pacing and defibrillation studies
Skåne University Hospital
2015-2025
Lund University
2009-2025
Van Andel Institute
2023
Corewell Health Blodgett Hospital
2023
Spectrum Health
2018-2023
Scania (Sweden)
2014-2019
Sevoflurane sample data in a standard single patient ICU room, VieCuri Medical Centre. Physical of the room: 52 m3, air refreshing rate minimum 6/hr
Acute kidney injury (AKI) is a serious complication after lung transplantation, but the reported incidence varies in literature. No data on AKI have been published from Swedish transplantation program. The aim of our study was to investigate incidence, perioperative risk factors, and effects early postoperative acute (Kidney Disease Improving Global Outcomes [KDIGO] criteria) transplantation. A retrospective, nationwide 568 lung-transplanted patients Sweden between 2011 2020 performed. (any...
Abstract Background: To date, there are no known methods for preventing acute kidney injury after cardiac surgery. Increasing evidence suggests that erythropoietin has renal antiapoptotic and tissue protective effects. However, recent human studies have shown conflicting results. The authors aimed to study the effect of a single high-dose preoperatively on function coronary artery bypass grafting in patients with preoperative impaired function. Methods: This single-center, randomized,...
YUAN, S., et al. : Global Repolarization Sequence of the Ventricular Endocardium: Monophasic Action Potential Mapping in Swine and Humans. The aim this study was to evaluate global sequence repolarization over ventricular endocardium. Disturbances myocardial are associated with genesis arrhythmias. However, little is known about repolarization. action potentials (MAPs) were recorded from 61 ± 18 LV and/or RV sites ten healthy pigs 43 15 or eight patients using CARTO system. Local activation...
Sepsis-associated myocardial depression is associated with calcium desensitization and adrenergic uncoupling. We conducted a prospective randomized investigation on the effects of sensitizer, levosimendan, hemodynamics, blood flow, lactate metabolism during porcine endotoxemia. Twelve pigs were studied. Oxygen consumption was measured by indirect calorimetry, flow retrograde thermodilution. Pulmonary, arterial, venous indwelling catheters allowed measurements cardiac output, vascular...
Septic shock may cause splanchnic hypoperfusion. We hypothesized that levosimendan would improve systemic and hepatosplanchnic perfusion during endotoxemic shock.In 16 anesthetized pigs (31.4 +/- 3.4 kg), a jugular vein, carotid artery, the pulmonary artery (thermodilution), portal hepatic vein were cannulated for hemodynamic monitoring blood sampling. Ultrasonic flowprobes placed around superior mesenteric (SMA). In addition to 30 mL/kg of dextran 70 given before baseline, all animals...
Acute kidney injury is a common complication after cardiac surgery, leading to increased morbidity and mortality. One suggested cause for acute extracorporeal circulation-induced ischemia-reperfusion injury. In animal studies, cyclosporine has been shown reduce in the kidneys. We hypothesized that administering before circulation could protect kidneys patients undergoing surgery.The Cyclosporine Protect Renal Function Cardiac Surgery (CiPRICS) study was an investigator-initiated,...
In severe acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) is a life-prolonging treatment, especially among COVID-19 patients. Evaluation of lung injury progression challenging with current techniques. Diagnostic imaging or invasive diagnostics are risky given the difficulties intra-hospital transportation, contraindication biopsies, and potential for spread infections, such as in We have recently shown that particle flow rate (PFR) from exhaled breath...
Lung transplantation (LTx) is the only treatment option for end-stage lung disease. Despite improvements, primary graft dysfunction (PGD) remains leading cause of early mortality and precipitates chronic allograft dysfunction, main factor in late after LTx. PGD develops within first 72 hours impairs oxygenation capacity lung, measured as partial pressure oxygen (PaO2)/fraction inspired (FiO2). Increasing PaO2/FiO2 ratio thus critical has an impact on survival. There a general lack effective...
Introduction Acute kidney injury (AKI) after cardiac surgery is common and results in increased morbidity mortality. One possible mechanism for AKI ischaemia–reperfusion caused by the extracorporeal circulation (ECC), resulting an opening of mitochondrial permeability transition pore (mPTP) kidneys, which can lead to cell or death. Ciclosporin may block mPTP if administered before injury. We hypothesised that ciclosporin given start ECC decrease degree AKI. Methods analysis Protect Renal...
Background: Inhibition of nitric oxide synthase (NOS) has been claimed to be beneficial in septic shock. We investigated the overall and regional effects a NOS‐inhibitor on perfusion metabolism during severe endotoxic Methods: Nineteen anaesthetised pigs were catheterised ultrasonic flow‐probes placed around portal vein, hepatic artery, superior mesenteric artery. Thirteen animals given 3‐h infusion endotoxin; 6 these an N G ‐nitro‐L‐arginine‐methyl‐ester (L‐NAME) was started hour after...
The aim of the study was to explore global sequence atrial repolarization and its correlation that activation. Endocardial monophasic action potentials (MAPs) were sequentially recorded from 51 +/- 14 sites in right atrium ten healthy pigs using CARTO electroanatomic mapping system. Local activation time (AT), MAP duration, 90% (RT) obtained, these data, color coded three-dimensional maps AT RT sequences spatial distribution duration reconstructed. results were: (1) An recognizable all maps,...
Haemolysis occurring during cardiac surgery with cardiopulmonary bypass (CPB) is assumed to be a risk factor for postoperative acute kidney injury (AKI). Plasma alpha-1 microglobulin (A1M) may have protective role as haem scavenger. The aim of this study was evaluate the association between AKI and degree haemolysis course A1M concentrations surgery, respectively. We analysed plasma free haemoglobin (pfHb) in 25 patients undergoing surgery: before CPB; CPB 15 min intervals; after at four...
AbstractObjective : To evaluate the feasibility of monophasic action potential (MAP) mapping using a modified-tip NaviStar catheter in swine and humans. Methods MAP was performed at 71 - 21 atrial 60 16 ventricular sites 10 healthy pigs 56 one patient, an ordinary Navi-Star 30 patient 50 14 four patients. In additional 20 patients, MAPs were also recorded 9 2 or 12 catheter. Results pigs, plateau amplitudes 4.1 3.2 mV for 9.5 4.3 MAPs. both significantly higher than catheters, 15.7 8 3.0...
Acute kidney injury (AKI) in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is associated high mortality. The objective of this study was to investigate whether cytokine levels before the initiation ECMO treatment could predict AKI. We also aimed impact AKI on 30-day and 1-year mortality.Serum were analyzed 100 consecutive VA-ECMO-treated at pre-cannulation, 48 h post-cannulation, 8 days. Clinical data establish incidence outcome after start retrieved from...
The same mechanisms by which ultrasound enhances thrombolysis are described in connection with non-beneficial effects of ultrasound. present safety study was therefore designed to explore beneficial characteristics on the infarcted and non-infarcted myocardium. In an open chest porcine model (n = 17), myocardial infarction induced ligating a coronary diagonal branch. Pulsed frequency 1 MHz intensity 0.1 W/cm2 (ISATA) applied during one hour both tissue. These similar those used studies...
Abstract Background Despite being a lifesaving intervention for the most critically ill and circulatory compromised patients, veno-arterial extra-corporeal life support (VA-ECLS) is associated with mortality rate of nearly 60%. Understanding how immune response to VA-ECLS either promotes or impedes survival would both enhance risk stratification uncover new therapeutic strategies these patients. However, conventional enumeration peripheral blood mononuclear cells (PBMCs) their subsets have...
A potential measure of post-ischemic milieu in myocardium subject to acute ischemic injury is assess the so- called myocardial salvage index (SI) by relating final infarct size initial at risk (MaR). Cardiac magnetic resonance (CMR) has previously been shown enable determination both using late gadolinium enhancement and MaR T2- weighted imaging. This technique could thus potentially be used identify inflammatory responses that targeted accomplish cardioprotection. The aim this study was...
Dardashti, Alain; Ederoth, Per; Algotsson, Lars; Brondén, Björn; Grins, Edgars; Larsson, Mårten; Nozohoor, Shahab; Zinko, Galyna; Bjursten, Henrik Author Information
<sec> <title>BACKGROUND</title> Lung transplantation (LTx) is the only treatment option for end-stage lung disease. Despite improvements, primary graft dysfunction (PGD) remains leading cause of early mortality and precipitates chronic allograft dysfunction, main factor in late after LTx. PGD develops within first 72 hours impairs oxygenation capacity lung, measured as partial pressure oxygen (PaO<sub>2</sub>)/fraction inspired (FiO<sub>2</sub>). Increasing...