A5024163970- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Trauma and Emergency Care Studies
- Trauma Management and Diagnosis
- Cardiac Imaging and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
- Ultrasound and Hyperthermia Applications
- Cardiac electrophysiology and arrhythmias
- Respiratory Support and Mechanisms
- Disaster Response and Management
- Atrial Fibrillation Management and Outcomes
- Non-Invasive Vital Sign Monitoring
- Emergency and Acute Care Studies
- Photoacoustic and Ultrasonic Imaging
- Cardiac Structural Anomalies and Repair
- Traumatic Brain Injury Research
- Injury Epidemiology and Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Thermoregulation and physiological responses
Lund University
2014-2024
Helsingborgs lasarett
2020-2024
Ideon Science Park
2011-2018
Background Mechanical chest compression (CC) is currently suggested to deliver sustained high-quality CC in a moving ambulance. This study compared the hemodynamic support provided by mechanical piston device or manual during ambulance transport porcine model of cardiopulmonary resuscitation. Methods and Results In simulated urban transport, 16 pigs cardiac arrest were randomized 18 minutes with LUCAS (n=8) (n=8). ECG, arterial right atrial pressure, together end-tidal CO
To deliver optimal patient care, evidence-based care is advocated and research needed to support health staff of all disciplines in deciding which options use their daily practice. Due the increasing complexity cardiac across life span patients combined with opportunities challenges multidisciplinary research, Science Committee Council on Cardiovascular Nursing Allied Professionals (CCNAP) recognised need for a position statement guide researchers, policymakers funding bodies contribute...
Resuscitation after cardiac arrest (CA) in the catheterization laboratory (cath-lab) using mechanical chest compressions (CC) during simultaneous percutaneous coronary intervention (PCI) is a strong recommendation 2015 European Council (ERC) guidelines. This study aimed at re-evaluating survival to hospital discharge and assess long term outcome this patient population. Patients presenting cath lab with spontaneous circulation, suffering CA requiring prolonged CC procedures between 2009 2013...
Abstract Background Chest compression is a lifesaving intervention in out‐of‐hospital cardiac arrest (OHCA), but the optimal metrics to assess its quality have yet be identified. The objective of this study was investigate whether new parameter, that is, variability chest compression‐generated transthoracic impedance (TTI), namely Imp CC , which measures consistency maneuver, relates resuscitation outcome. Methods This multicenter observational, retrospective included OHCAs with shockable...
The LUCAS™ device delivers mechanical chest compressions that have been shown in experimental studies to improve perfusion pressures the brain and heart as well augmenting cerebral blood flow end tidal CO2, compared with results from standard manual cardiopulmonary resuscitation (CPR). Two randomised pilot out-of-hospital cardiac arrest patients not improved outcome when CPR. There remains evidence small case series can be potentially beneficial specific situations. This multicentre study is...
To determine compression force variation (CFV) during mechanical cardiopulmonary resuscitation (CPR) and its relationship with CPR-related injuries survival.Adult non-traumatic OHCA patients who had been treated CPR were evaluated for using chest X-rays, thoracic computed tomography or autopsy. The CFV exerted by the LUCAS 2 device was calculated as difference between maximum minimum values categorised into three different groups (high positive ≥ 95 newton (N), high negative ≤ -95 N, low...
Experimental active compression-decompression (ACD) CPR is associated with increased haemodynamic outcomes compared to standard mechanical chest compressions. Since no clinically available compression device capable of ACD-CPR, we modified the LUCAS 2 (Physio-Control, Lund, Sweden) deliver hypothesising it would improve on pigs cardiac arrest. The delivering 5 cm compressions or without decompression above anatomical level was studied in a randomized crossover design 19 Norwegian domestic...
Introduction: Oxygen is considered to have analgesic effects, but the evidence weak. may be harmful ischemic myocardium. The aim was investigate effect of oxygen during percutaneous coronary intervention (PCI) and evaluate cardiac injury.
Effects of increased adenosine dose in the assessment fractional flow reserve (FFR) were studied relation to FFR results, hemodynamic effects and patient discomfort. require maximal hyperemia mediated by adenosine. Standard is 140 μg/kg/min administrated intravenously. Higher doses are commonly used clinical practice, but an extensive comparison between standard intravenous a high (220 μg/kg/min) has previously not been performed.Seventy-five patients undergoing received adenosine, followed...
In current guidelines, prolonged cardiopulmonary resuscitation (CPR) mandates administration of repeated intravenous epinephrine (EPI) doses. This porcine study simulating a CPR-situation in the coronary catheterisation laboratory, explores effect EPI-administrations on perfusion pressure (CPP), continuous artery flow average peak velocity (APV) and amplitude spectrum area (AMSA). Thirty-six pigs were randomized 1:1:1 to EPI 0.02 mg/kg/dose, 0.03 mg/kg/dose or saline (control) an...
Abstract Background Mechanical chest compressions (CCs) have been shown capable of maintaining circulation in humans suffering cardiac arrest for extensive periods time. Reports documented a visually normalized coronary blood flow during angiography such cases (TIMI III flow), but it has never actually measured. Only indirect measurements the with on-going mechanical CCs performed previously through measurement perfusion pressure (CPP). In this study our aim was to correlate average peak...
Ultrasound (US) has been used to enhance thrombolytic therapy in the treatment of stroke. Considerable attenuation US intensity is however noted if applied over temporal bone. The aim this study was therefore explore possible changes effect drugs during low-intensity, high-frequency continuous-wave ultrasound (CW-US) exposure.Clots were made from fresh venous blood drawn healthy volunteers. Each clot 1.4 ml and left coagulate for 1 hour a plastic test-tube. were, 3600 IU streptokinase (SK)...
Treating patients in cardiac arrest (CA) with mechanical chest compressions (MCC) during percutaneous coronary intervention (PCI) is now routine many catheterization laboratories (cath-lab) and more aggressive treatment modalities, including extracorporeal CPR are becoming common. The cath-lab setting enables monitoring of vital physiological parameters other clinical factors that can potentially guide the resuscitation effort. This retrospective analysis attempts to identify such associated...
Abstract Objective The quality of cardiopulmonary resuscitation (CPR) affects outcomes from cardiac arrest, yet manual CPR is difficult to administer. Although mechanical (mCPR) devices offer high CPR, only limited data describe their deployment, interaction with standard (sCPR), and the consequent effects on chest compression continuity patient outcomes. We sought between sCPR mCPR impact sCPR‐mCPR transition upon in adult out‐of‐hospital arrest (OHCA). Methods analyzed all ventricular...
In view of the potentially beneficial effects ultrasound on fibrinolysis, we aimed to study possible drawbacks low-energy nonperfused and perfused brain tissue.A model transient focal ischemia in anesthetized rats was used. Rats were randomly assigned 1 3 groups: first exposed ultrasound, second a control group, third method group. each right middle cerebral artery occluded for 1.5 hours, during which time group hour pulsed (1 MHz; spatial-average temporal-average intensity, 0.1 W/cm2 at...
Abstract Background Long term β-blocker therapy after myocardial infarction (MI) reduces mortality and recurrent MI but evidence for this treatment predates contemporary acute coronary care. is a key quality of care indicator in the Swedish national register care, Riks-HIA. Between 2011 2015 declining number MI-patients discharged with from unit (CCU) at Helsingborg other hospitals was reported. This retrospective observational study aimed to investigate causes discharge without relate it...
The study of thoracic injuries and biomechanics during CPR requires detailed studies that are very scarce. role the heart in has not been determined. This aimed to determine risk factors importance for serious ribcage damage due CPR.