A5013464699- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- Disaster Response and Management
- Trauma Management and Diagnosis
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Atrial Fibrillation Management and Outcomes
- Airway Management and Intubation Techniques
- Poisoning and overdose treatments
- SARS-CoV-2 and COVID-19 Research
- Family and Patient Care in Intensive Care Units
- Cardiac Ischemia and Reperfusion
- RNA modifications and cancer
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Injury Epidemiology and Prevention
- Long-Term Effects of COVID-19
- Viral Infections and Outbreaks Research
- Infection Control and Ventilation
- Human Rights and Development
- COVID-19 epidemiological studies
- Non-Invasive Vital Sign Monitoring
- COVID-19 and healthcare impacts
Italian Resuscitation Council
2017-2025
Ospedale Santa Chiara
2021-2025
Provincia Autonoma di Trento
2022-2024
University of Oxford
2021
University of Milan
2017-2021
Prince Charles Hospital
2021
Mario Negri Institute for Pharmacological Research
2018-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2020
RELX Group (United States)
2019
University of Trento
2011
Background Mechanical chest compression (CC) is currently suggested to deliver sustained high-quality CC in a moving ambulance. This study compared the hemodynamic support provided by mechanical piston device or manual during ambulance transport porcine model of cardiopulmonary resuscitation. Methods and Results In simulated urban transport, 16 pigs cardiac arrest were randomized 18 minutes with LUCAS (n=8) (n=8). ECG, arterial right atrial pressure, together end-tidal CO
Supplementation of antithrombin might decrease the amount heparin needed to achieve a given anticoagulation target during extracorporeal membrane oxygenation. However, exogenous itself may increase risk bleeding. We conceived study evaluate effect supplementation in adult patients requiring venovenous oxygenation for respiratory failure on dose, adequacy anticoagulation, and safety.Prospective randomized controlled trial.ICUs two Italian referral centers.Adult severe unfractionated systemic...
Widespread basic life support (BLS) training plays a central role in improving cardiac arrest (CA) survival. This study presents an extensive analysis of numbers, candidates' characteristics, and outcomes over 10 years BLS provider courses organized by the Italian Resuscitation Council (IRC) Italy. is retrospective data recorded national IRC database from January 2014 to December 2023. Candidates' demographic professional factors were analyzed with regional differences course outcomes. Over...
Cardiovascular and respiratory diseases (CVRD) are the leading causes of death worldwide. The construction health digital twins for patient monitoring is becoming a fundamental tool to reduce invasive procedures, lower healthcare costs, minimize hospitalization, design clinical trials personalize therapies. aim this study investigate feasibility machine learning-based healthy subjects CVRD patients in an silico context. In particular, population virtual subjects, both with CVRD, was created...
Accurate classification of nonsmall cell lung cancers is paramount clinical relevance, as novel chemotherapeutic agents show different efficacy in adenocarcinomas (ADCs) compared with squamous carcinomas (SQCCs). Cyto and histomorphology may sometimes be insufficient for this distinction immunohistochemistry improve diagnostic accuracy. The measurement miR-205 another tool the between ADC SQCC. aim our study was to compare morphologic immunohistochemical relative quantification miR-21...
Large cell carcinomas (LCCs) of the lung are heterogeneous and may be different lineages. We analyzed 56 surgically resected tumors classified as LCC on basis pure morphologic grounds, using a panel immunophenotypic markers (adenocarcinoma [ADC]-specific, thyroid transcription factor-1, cytokeratin 7, napsin A; squamous carcinoma [SQCC]-specific, p63, 5, desmocollin 3, Δnp63) quantitative analysis microRNA-205 (microRNA sample score [mRSS]). Based immunoprofiles 19 (34%) cases were...
Background Ventilation with the noble gas argon (Ar) has shown neuroprotective and cardioprotective properties in different vitro vivo models. Hence, effects of Ar were investigated a severe, preclinically relevant porcine model cardiac arrest. Methods Results Cardiac arrest was ischemically induced 36 pigs left untreated for 12 minutes before starting cardiopulmonary resuscitation. Animals randomized to 4-hour post-resuscitation ventilation with: 70% nitrogen-30% oxygen (control); 50%...
The COVID-19-related shortage of ICU beds magnified the need tools to properly titrate ventilator assistance. We investigated whether bedside-available indices such as ultrasonographic changes in diaphragm thickening ratio (TR) and tidal swing central venous pressure (ΔCVP) are reliable estimates inspiratory effort, assessed esophageal (ΔPes).Prospective, observational clinical investigation intensive care unit a tertiary Hospital. Fourteen critically-ill patients were enrolled (age 64 ± 7...
Normal levels of plasma antithrombin (AT) activity might decrease heparin requirements to achieve an adequate level anticoagulation during treatment with extracorporeal membrane oxygenation (ECMO). Acquired AT deficiency ECMO is common, but formal recommendations on target, timing, and rate supplementation are lacking. Thus, we conceived a pilot trial evaluate the feasibility safety prolonged in patients requiring veno-venous for respiratory failure. Grifols Antithrombin Research Awards...
Primary vasopressor efficacy of epinephrine during cardiopulmonary resuscitation (CPR) is due to its α-adrenergic effects. However, plays β1-adrenergic actions, which increasing myocardial oxygen consumption may lead refractory ventricular fibrillation (VF) and poor outcome. Effects a single dose esmolol in addition CPR were investigated porcine model VF with an underlying acute infarction. was ischemically induced 16 pigs left untreated for 12 min. During CPR, animals randomized receive (30...
Background. The quality of cardiopulmonary resuscitation (CPR) is pivotal in improving the outcome cardiac arrest. Nevertheless, there evidence that even professional rescuers may deliver ineffective chest compressions (CCs). We sought to evaluate impact a CPR feedback device on CC performed by supposedly highly trained and skilled population attendees national annual congress Italian Resuscitation Council. Methods. A total 202 were enrolled perform 2 min without feedback, followed 5 rest...