A5089777422- High Altitude and Hypoxia
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Calibration and Measurement Techniques
- Thermoregulation and physiological responses
- Optical Imaging and Spectroscopy Techniques
- Infrared Target Detection Methodologies
- CCD and CMOS Imaging Sensors
- Empathy and Medical Education
- Asthma and respiratory diseases
- Media Influence and Health
- Optical Coherence Tomography Applications
- Retinal Imaging and Analysis
- Respiratory and Cough-Related Research
- Cancer, Hypoxia, and Metabolism
- COVID-19 Pandemic Impacts
- Disaster Response and Management
- Photoacoustic and Ultrasonic Imaging
- Cardiovascular and Diving-Related Complications
- Simulation-Based Education in Healthcare
- Hemoglobin structure and function
- Child Development and Digital Technology
Barts Health NHS Trust
2016-2024
Royal London Hospital
2024
University College London
2012-2021
National Institute for Health Research
2017-2020
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2017-2020
Asthma UK
2020
Royal Free London NHS Foundation Trust
2016-2020
Barnet Hospital
2020
Newham University Hospital
2016
Anecdotal reports suggest that Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitude, despite exhibiting lower arterial oxygen content than acclimatized lowlanders. This study tested the hypothesis Sherpas exposed hypobaric on ascent 5,300 m develop increased microcirculatory blood flow as a means of maintaining tissue delivery. Incident dark-field imaging was used obtain images sublingual microcirculation from 64 and 69 Serial measurements were obtained...
The 'Cytocam' is a third generation video-microscope, which enables real time visualisation of the in vivo microcirculation. Based upon principle incident dark field (IDF) illumination, this hand held computer-controlled device was designed to address technical limitations its predecessors, orthogonal polarization spectroscopy and sidestream (SDF) imaging. In manuscript, we aimed compare quality sublingual microcirculatory image acquisition between IDF SDF devices.Using scoring (MIQS)...
Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim this study was describe the relationship between physiological variables and incidence AMS during ascent 5300 m. A total 332 lowland-dwelling volunteers followed an identical profile on staggered treks. Self-reported symptoms were recorded daily using Lake Louise score (mild 3-4; moderate-severe ≥5), alongside measurements (heart rate, respiratory rate (RR), peripheral oxygen saturation (SpO
<ns4:p>Present knowledge of how the microcirculation is altered by prolonged exposure to hypoxia at high altitude incomplete and modification existing analytical techniques may improve our considerably. We set out use a novel simplified method measuring <ns4:italic>in vivo</ns4:italic> capillary density during an expedition using CytoCam incident dark field imaging video-microscope.</ns4:p><ns4:p> The data capture involved recording one-second images mucosal surface inner lip reveal about...
Sidestream dark field (SDF) imaging enables direct visualisation of the microvasculature from which quantification key variables is possible. The new MicroScan USB3 (MS-U) video-microscope a hand-held SDF device that has undergone significant technical upgrades its predecessor, Analogue (MS-A). MS-U claims superior quality sublingual microcirculatory image acquisition over MS-A, however, this yet to be robustly confirmed. In manuscript, we therefore compare between these two devices....
Asthma is the most common chronic condition among young people within USA. This review discusses pediatric asthma education and provides evidence-based recommendations for reducing burden of on health care. Within schools there robust evidence to suggest that peer-to-peer schemes are very effective in complementing support provided by school nurses. We report our experience using medical students an program. In hospital environment, postexacerbation period a key educative window both...
Objectives Asthma affects 1.1 million children in the UK, substantially impacting quality of life and leading to significant morbidity mortality. Effective asthma self-management, education empowerment can lead a reduction related We hypothesized that medical students significantly improve school children’s knowledge awareness asthma, at least short term. sought implement student-led educational intervention program tailored school-aged children, measure immediate improvements asthma-related...
<b>Introduction:</b> Non-invasive ventilation (NIV) is increasingly being used in hospitals to treat acute respiratory failure. During undergraduate training, there little emphasis on the practical aspects of NIV. This simulation training day raised awareness current NIV protocol and increasing confidence when making clinical decisions. <b>Objectives:</b> To assess effectiveness days across a range healthcare professionals. <b>Methods:</b> were designed conducted for ward nurses, critical...
Two examples of images obtained using the sidestream dark field video-microscope. (PNG 1188 kb)
Two examples of images obtained using the incident dark field video-microscope. (PNG 1659 kb)