A5017457657- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Ureteral procedures and complications
- Neonatal Health and Biochemistry
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Neuroscience of respiration and sleep
- Infant Nutrition and Health
- Preterm Birth and Chorioamnionitis
- Pelvic floor disorders treatments
- Anesthesia and Sedative Agents
- Prenatal Screening and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Retinopathy of Prematurity Studies
- Congenital Diaphragmatic Hernia Studies
- Gestational Trophoblastic Disease Studies
- Prenatal Substance Exposure Effects
- Nausea and vomiting management
- Kidney Stones and Urolithiasis Treatments
- Epilepsy research and treatment
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2023-2025
Research Network (United States)
2023-2025
BridgeBio (United States)
2024
Duke University
2015-2023
WakeMed
2018-2023
Duke Regional Hospital
2023
Health and Human Development (2HD) Research Network
2023
University Hospital Southampton NHS Foundation Trust
2021
University College London
1983-2021
University of Southampton
2021
<h3>Objective</h3> To evaluate the efficacy of triple-lumen central venous catheters coated with a combination product chlorhexidine and silver sulfadiazine (CSS) in reducing incidence local catheter infection catheter-related bacteremia. <h3>Design</h3> Randomized, controlled trial. <h3>Setting</h3> The surgical intensive care units university hospital. <h3>Patients</h3> All patients who needed catheterization were randomized to receive either an uncoated (n=157) or CSS (n=151). <h3>Main...
Abstract Background Used alone, the MAS5.0 algorithm for generating expression summaries has been criticized high False Positive rates resulting from exaggerated variance at low intensities. Results Here we show, with replicated cell line data, that, when used alongside detection calls, MAS5 can be both selective and sensitive. A set of differentially expressed transcripts were identified that found to changing by MAS5, but unchanging RMA GCRMA. Subsequent analysis real time PCR confirmed...
By the most recent estimates, 18.8 million people in U.S. have been diagnosed with diabetes and an additional 7 are believed to be living undiagnosed diabetes. At same time, 79 estimated blood glucose levels range of prediabetes or categories increased risk for Thus, more than 100 Americans at developing devastating complications (1). Diabetes self-management education (DSME) is a critical element care all those disease. It necessary order prevent delay (2–6) has elements related lifestyle...
Importance Meta-analyses suggest that corticosteroids may be associated with increased survival without cerebral palsy in infants at high risk of bronchopulmonary dysplasia (BPD) but are adverse neurologic outcomes low-risk infants. Whether this association exists contemporary practice is uncertain because most randomized clinical trials administered earlier and higher doses than currently recommended. Objective To evaluate whether the pretreatment death or grade 2 3 BPD 36 weeks’...
Importance Observational studies often report that anemia and red blood cell (RBC) transfusions are associated with a higher risk of necrotizing enterocolitis (NEC) among extremely low-birthweight (ELBW) infants. Objective To evaluate whether there is temporal association between 72-hour hazard periods exposure to RBC NEC ELBW infants randomized either or lower hemoglobin transfusion thresholds. Design, Setting, Participants This post hoc secondary analysis 1690 who survived postnatal day 10...
Summary— Seventeen patients who developed urethral strictures following catheterisation have been studied; 14 of these (82%) were catheterised for standard monitoring purposes during and after major heart surgery, which was a coronary artery bypass graft (CABPG) in 12 cases. The possible aetiological mechanisms the development this complication are discussed. Animal experiments designed carried out to compare effects different catheter materials on mucosa. Silicone catheters provoked least...
Summary— One hundred and four patients were randomised for the study. Fifty‐five entered into D‐Trp‐6‐LHRH group 49 orchiectomy group. All pre‐treatment patient characteristics similar testosterone levels at 1 month or later in castrate range both groups. Forty‐six (83%) 40 (82%) had a partial remission stable disease 3 months later. There was no significant difference between groups response survival. Three “flare” first 10 days of treatment. The flare symptoms resolved by end 4 to 8 weeks....
Importance Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health Human Development Neonatal Research Network (NICHD NRN) Hydrocortisone Trial, hydrocortisone neither reduced rates BPD or death nor increased impairment (NDI) death. Objective To determine whether estimated grades 2 to 3 is associated with effect on composite outcomes (1) (2) moderate severe NDI...
Importance Redirection of care refers to withdrawal, withholding, or limiting escalation treatment. Whether maternal social determinants health are associated with redirection discussions merits understanding. Objective To examine associations between and for infants born extremely preterm. Design, Setting, Participants This is a retrospective analysis prospective cohort at less than 29 weeks’ gestation April 2011 December 2020 19 National Institute Child Health Human Development Neonatal...
Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim this study was describe the relationship between physiological variables and incidence AMS during ascent 5300 m. A total 332 lowland-dwelling volunteers followed an identical profile on staggered treks. Self-reported symptoms were recorded daily using Lake Louise score (mild 3-4; moderate-severe ≥5), alongside measurements (heart rate, respiratory rate (RR), peripheral oxygen saturation (SpO
Purpose: We examined the effects of magnesium on premature neonatal outcomes complicated by chorioamnionitis.Materials and methods: conducted a secondary analysis data from BEAM Trial, an RCT to determine if antenatal decreases incidence CP in preterm birth. compared effect sulfate presence or absence chorioamnionitis. Outcomes include CP, IVH, NEC, BPD, assessments mental motor disability. Logistic regression was used estimate adjusted odds ratios each outcome.Results: About 1944 women were...
Infant delirium is an under-recognized clinical entity in neonatal intensive care, and earlier identification treatment could minimize morbidities associated with this condition. We describe a case of 6-month-old former 32 weeks gestation infant undergoing prolonged mechanical ventilation course diagnosed related to the combination his underlying illness use multiple sedative analgesic medications. Initiation atypical antipsychotic risperidone allowed for weaning from continuous infusions...
Summary— There is no recognised policy regarding the timing of urethral catheter removal, although early morning removal commonly practised. Removing at midnight allows patients to return a normal voiding pattern more rapidly and leave hospital earlier.
One hundred thirteen patients were randomized for the study. There was no significant difference between groups response or survival. The incidence of side effects related to reduction testosterone similar in both groups. Disease “flare” seen three treated with long-acting D-Trp-6 LH-RH. All symptoms resolved by end 8 weeks. less psychological morbidity LH-RH group but did not reach statistical significance. Our results indicate that offers a safe and effective alternative surgical orchidectomy.
MEDICAL JOURAL major surgical centres and most had a trained nurse, visiting doctor, psychotherapist.Employment of the child after school was often difficult.