A5101988388- Dementia and Cognitive Impairment Research
- Palliative Care and End-of-Life Issues
- Mobile Health and mHealth Applications
- Health Systems, Economic Evaluations, Quality of Life
- Cholinesterase and Neurodegenerative Diseases
- Smoking Behavior and Cessation
- Frailty in Older Adults
- Alzheimer's disease research and treatments
- Pharmaceutical Practices and Patient Outcomes
- Folate and B Vitamins Research
- Health, Environment, Cognitive Aging
- Health and Well-being Studies
- Neuroscience and Neuropharmacology Research
- Chronic Disease Management Strategies
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- Cardiovascular Health and Disease Prevention
- Media Influence and Health
- Child Development and Digital Technology
- Esophageal and GI Pathology
- Systemic Lupus Erythematosus Research
- Cancer survivorship and care
- Genetic Neurodegenerative Diseases
- Mental Health and Psychiatry
South Warwickshire NHS Foundation Trust
2024
Health and Human Development (2HD) Research Network
2023
ICF International (United States)
2021-2022
University of Iowa
2020
James A. Haley Veterans' Hospital
2020
Georgetown University
2020
University of South Florida
2020
American Academy of Neurology
2015-2020
Johns Hopkins Medicine
2020
Johns Hopkins University
2020
Polymorphisms in the cholesteryl ester transfer protein (CETP) gene have been associated with exceptional longevity and lower cardiovascular risk, but associations memory decline dementia risk are unclear.To test hypothesis that a single-nucleotide polymorphism (SNP) at CETP codon 405 (isoleucine to valine V405; SNP rs5882) is rate of incident dementia, including Alzheimer disease (AD).Prospective cohort study comprising 608 community-dwelling adults without aged 70 years or older from...
``Vascular cognitive impairment'' refers to impairment caused or associated with vascular risk factors, and encompasses a spectrum ranging from mild dementia. We examined the association of leisure activity participation developing VCI in Bronx aging study. Over 21 years, 71 401 participants who were free dementia at entry developed (49 without dementia). derived Cognitive Physical Activity Scales based on frequency participation. A 1-point increase Cognitive, but not Scale, was lower...
As new and more effective treatments for Alzheimer's disease (AD) emerge, the development of efficient screening strategies in educationally racially diverse primary care settings has increased importance. A set candidate tests an independent diagnostic assessment were administered to a sample 318 patients treated at geriatric center. Fifty-six subjects met criteria dementia. Exploratory analysis led three two-stage that differed composition first stage or Rapid Dementia Screen, which is...
Importance Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health Human Development Neonatal Research Network (NICHD NRN) Hydrocortisone Trial, hydrocortisone neither reduced rates BPD or death nor increased impairment (NDI) death. Objective To determine whether estimated grades 2 to 3 is associated with effect on composite outcomes (1) (2) moderate severe NDI...
Abstract Mutations in the leucine‐rich repeat kinase 2 gene ( LRRK2 , PARK8) are most commonly identified monogenic etiology of Parkinson disease (PD). Over‐represented Ashkenazi Jewish population, these mutations transmitted an autosomal dominant manner with age‐dependent reduced penetrance. The natural history and penetrance elderly is controversial inadequately studied. We conducted a nested cohort study community‐based aging (the Einstein Aging Study). Six elderly, initially...
Background eHealth interventions can help cancer survivors self‐manage their health outside the clinic. Little is known about how best to engage and assist across age treatment spectra. Methods The American Cancer Society conducted a randomized controlled trial that assessed efficacy of, engagement with, Springboard Beyond Cancer, an self‐management program for survivors. Intent‐to treat analyses effects of intervention (on‐treatment vs completed) overall (n = 176; 88 control, arm)...
To determine whether dementia status and medical burden were independent predictors of emergency department (ED) visits hospitalizations in older patients from an urban geriatric practice participating a primary care based cognitive screening program.A comprehensive chart review was conducted for 300 African American Caucasian patients, including 46 with prevalent 28 incident using the Cumulative Illness Burden Scale. Hospital-based claims data used to retrieve ED hospital admissions 5 years...
The Dementia Management Quality Measurement Set was first developed and released in 2013 by the PCPI Foundation1 (formerly American Medical Association [AMA]–convened Physician Consortium for Performance Improvement [PCPI]). Developed an appointed multistakeholder technical expert panel (TEP), supported staff from AMA, Academy of Neurology Institute (AANI), Psychiatric (APA), Directors Association, Geriatric Society. Several original measures were included into Centers Medicare Medicaid...
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Mobile health strategies for smoking cessation (eg, SMS text messaging-based interventions) have been shown to be effective in helping smokers quit. However, further research is needed better understand user experiences with these platforms.
Over 78,000 new CNS tumors are diagnosed each year in the United States, nearly one-third of which primary malignant brain tumors,1 and US prevalence is approximately 688,000.2 While neoplasms represent only 1.4% cancer diagnoses, 2.7% deaths related to neoplasms,3 it estimated that 16,947 will result from 2017.1 Population-based studies have shown socioeconomic disparities present within neuro-oncology community,4–7 highlighting need for a unified system quality metrics this growing field....
May 6, 2019April 9, 2019Free AccessAn unusual late presentation of anti-NMDA Receptor (NMDA-R) Autoimmune Encephalitis following Herpes Simplex Virus (HSV) (P2.2-014)Amr Ewida, Kimberly Laxton, Anqi Lou, Neil Suryadevara, and Amy SandersAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P2.2-014 Letters to the Editor
Anterograde Amnesia after Methamphetamine Lab Exposure Background: Some known toxic exposures can produce detrimental cognitive deficits.Yet, very few substances have been linked to the development of anterograde amnesia.Here, we report a novel case middle-age man who presented with profound and apparently permanent amnesia following his exposure clandestine methamphetamine laboratory.Case Report: A 47 year-old, right-handed in 2013 history memory loss seizures since 2001, when he was...
We estimated rates of memory decline and relative risks dementia in carriers non-carriers a minor (V) allele at codon 405 the CETP gene (isoleucine to valine, I405V; NCBI dbSNP rs5882) population-based longitudinal aging study. allelic variants have been associated with human exceptional longevity. previously reported that V405 homozygosity is preserved global cognition Ashkenazi Jewish (AJ) centenarians V-allele overrepresented non-demented AJ subjects Einstein Aging Study (EAS)....
A loss of function variant in the cholesterol ester transfer protein (CETP V405V) gene is associated with a decreased risk incident dementia. Pain interference has been doubling for We hypothesize that CETP genotype may modify effect pain on The Einstein Aging Study longitudinal, community-based study which follows adults over age 70. Starting 1998, we assessed intensity and (moderate/severe versus none or slight) using SF-36, V405V I405V I404I). modeled dementia Cox proportionate hazard...
A common single nucleotide polymorphism in the gene for progranulin (C→T at position 78 3'UTR of GRN rs5848), which is associated with reduced expression GRN, was recently reported to increase risk frontotemporal lobar degeneration ubiquitin-positive inclusions (FTLD-U). HapMap data suggest that T allele over-represented an African population. Whether this true Americans not known. Furthermore, dementia more among than Caucasians. Given these observations, we hypothesized rs5848 CT and TT...