A5075809460- Acute Lymphoblastic Leukemia research
- Folate and B Vitamins Research
- Childhood Cancer Survivors' Quality of Life
- Pancreatic function and diabetes
- Microbial Metabolites in Food Biotechnology
- Skin and Cellular Biology Research
- Metabolomics and Mass Spectrometry Studies
- Plant Reproductive Biology
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Food composition and properties
- Botanical Research and Applications
- Metabolism and Genetic Disorders
- Concrete and Cement Materials Research
- Alzheimer's disease research and treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Wnt/β-catenin signaling in development and cancer
- Pharmacogenetics and Drug Metabolism
- Dementia and Cognitive Impairment Research
- Chronic Disease Management Strategies
- Porphyrin Metabolism and Disorders
- Biosimilars and Bioanalytical Methods
- MicroRNA in disease regulation
- Economic and Financial Impacts of Cancer
Instituto Politécnico Nacional
2011-2025
Durango Institute of Technology
2012-2022
Mexican Social Security Institute
2006-2014
Universidad de Guadalajara
2003-2005
The widely available options of different manufacturers in dental implant systems have complicated the selection criteria process for periodontists, necessitating careful consideration various factors when selecting suitable solutions individual patient needs. Optimal requires patient-specific factors, design, and surgical technique. Understanding biomechanical behavior implant-tissue interactions is crucial achieving successful long-lasting therapy. To adequately address this issue improve...
The constant evolution and applications of metallic nanoparticles (NPs) make living organisms more susceptible to being exposed them. Among the most used are zinc oxide (ZnO-NPs). Therefore, understanding molecular effects ZnO-NPs in biological systems is extremely important. This review compiles main mechanisms that induce cell toxicity by exposure reported vitro research models, with special attention mitochondrial damage. Scientific evidence indicates have a cytotoxic effect depends on...
Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx the Latin American and Caribbean (LAC) region remains scarce, with limited information some populations. Thus, extrapolations are complicated, especially mixed In this paper, we reviewed analyzed pharmacogenomic knowledge among LAC scientific clinical community examined barriers to application. We performed a search for publications trials worldwide evaluated contribution of LAC. Next, conducted...
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in world. Doxorubicin (Dox) a very useful drug these patients, however, one of main adverse effects caused by use Dox cardiotoxicity (CT). Protein-calorie malnutrition (PCM) factor that, among others, can influence development CT due to Dox. The aim our study was associate PCM as risk for induced Mexican children with ALL. We included 89 ALL who were treated Dox, from October 2018 July 2023, and whom 14 developed some...
Abstract Introduction Leptin (LEP) and its receptor (LEPR) participate in the immunological response during infection. LEP serum levels rise sepsis. In patients with peritonitis, an insufficient elevation is associated increased risk of death. As gene variants LEPR have been diverse pathologic conditions, we explored association genetic polymorphisms or death secondary peritonitis. Methods A case control study was undertaken. Gene -2548G > 223A G polymorphism were determined 74 patients....
The SLC38A4 gene is related to system 'A' activity, which seems be impaired gluconeogenesis. objective of this study was determine whether the 292 C>T and 1304 G>A polymorphisms are associated with hyperglycaemia in humans.A total 227 individuals were enrolled a case-control study, defined by plasma glucose levels ≥95 mg/dL. Genotyping carried out using real-time polymerase chain reaction.The frequency mutant alleles for single-nucleotide polymorphism (SNP) 23.6% 30.2% SNP C>T. allele T case...
A beverage made from a combination of Agave sap (AS) and prickly pear juice (PPJ) was ana-lyzed for its nutrients, bioactive potentially health-promoting compounds. The evaluated ability to act as an antioxidant, regulate glycemic properties, undergo gut bacterial fermentation in vitro. major mono- oligosaccharides present the were galacturonic acid (217.74±13.46 mg/100 mL), rhamnose (227.00±1.58 fructose (158.16±8.86 mg/mL). main phenolic compounds identified protocatechuic (440.31±3.06 mL)...
Peroxisome proliferator-activated receptors (PPARs) play roles in glucose and lipid metabolism regulation. Pro12Ala PPAR-γ2 +294T/C PPAR-δ have been associated with dyslipidemia, hyperglycemia high body mass index (BMI). We compared metabolic traits determined associations or polymorphism among teenagers from different ethnicity. Four hundred twelve samples previous biochemical biometric measurements were used. Genomic DNA peripheral blood was extracted analyzed by end-point PCR for PPAR-γ2....
Abstract Background: Acute lymphoblastic leukemia (ALL) is one of the most frequent oncological disorders in pediatric populations. To date, drug choice for treatment ALL methotrexate, a associated with high risk adverse reactions (ADRs). The xanthine oxidase ( XO ) polymorphisms, 1936A>G and 2107A>G , as well polymorphic variants derived from ATP-binding cassette transporter gene subfamilies, ABCB1 ABCC5 resistant codifying genes, are implicated precursors drug-related neurologic,...
Canine distemper is caused by canine virus (CDV), a multisystemic infectious disease with high morbidity and mortality rate in dogs. Nanotechnology represents development opportunity for new molecules antiviral effects that may become effective treatments veterinary medicine. This study evaluated the efficacy safety of silver nanoparticles (AgNPs) 207 CDV, naturally infected, mixed-breed dogs exhibiting clinical signs non-neurological neurological phases disease. Group 1a included 52...
Mitochondrial dysfunction has been thought to contribute Alzheimer disease (AD) pathogenesis through the accumulation of mitochondrial DNA mutations and net production reactive oxygen species (ROS). cytochrome c-oxidase plays a key role in regulation aerobic energy is composed 13 subunits. The 3 largest subunits (I, II, III) forming catalytic core are encoded by DNA. aim this work was look for gene II ( MTCO ) blood samples from probable AD Mexican patients. sequenced 33 patients with...
Acute lymphoblastic leukemia (ALL) is a frequent neoplasia occurring in children. The most commonly used drug for the treatment of ALL methotrexate (MTX), an anti-folate agent. Previous studies suggest that folate transporters play role prognosis and genetic polymorphism genes encoding may increase risk ALL. Therefore, main goal this study was to determine associations among six polymorphisms four related with transporter pathway relationship occurrence Mexican A case-control performed 73...
Abstract Congenital palmar polyonychia (CPP) is a rare and usually sporadic birth defect. We report on Mexican girl with CPP of both 5th fingers her sister ectrodactyly ulnar ray deficits agenesis the ulna. In previous reports, has been seen in involvement ulna digital rays postaxial polydactyly. Such findings observed our patients can be considered form CPP. Autosomal dominant inheritance more likely based informative families vertical transmission instances male‐to‐male transmission. The...
Objective : To determine the β ‐amyloid precursor protein ( APP) isoforms ratio as a risk factor for Alzheimer’s Disease and to assess its relationship with demographic genetic variables of disease. Methods Blood samples from 26 patients fulfilling NINCDS‐ADRDA diagnostic criteria AD 46 healthy control subjects were collected Western blotting APP. A APP isoforms, in optical densities, between upper band (130 Kd) lower bands (106–110 was obtained. Odds ratios obtained this component. Results...
Mexico ranks 2nd in adult obesity and 4th milk intake worldwide. Low levels of IGF-1 have been related to can be reverted by intake. The rs6214 polymorphism has associated with an increase the expression IGF-1. Therefore, aim study was evaluate association between both, intake, obesity. We analysed 99 volunteers, without a history for presence this through qPCR body composition electro-bioimpedance. Univariate logistic regression analyses showed that TT genotype is inversely fat mass....
In this study, a beverage made from combination of Agave sap (AS) and prickly pear juice (PPJ) was analyzed for its nutrients bioactive potentially health-promoting compounds. The evaluated ability to act as an antioxidant, regulate glycemic properties, undergo gut bacterial fermentation in vitro. major mono- oligosaccharides present the were galacturonic acid (217.74 ± 13.46 mg/100 mL), rhamnose (227.00 1.58 fructose (158.16 8.86 mg/mL). main phenolic compounds identified protocatechuic...
L-asparaginase (L-Asp) is an essential enzyme in the treatment of patients with Acute Lymphoblastic Leukemia (ALL), commonly associated adverse events (AE). Knowing pharmacokinetic and pharmacodynamic (PK/PD) parameters L-Asp as well its relationship development AE important strategy search to improve efficacy safety treatment. Seventy-four children ALL that were being treated L-Asp, included. One three blood samples randomly obtained from each patient, at times 0 30 hours, until completing...
The present study describes the incorporation of mine tailings from silver La Guitarra in manufacture lightweight prefabricated panels (LPPs). Tailings have concentrations heavy metals below maximum permissible levels according to Mexican regulations. Their acidity potential (AP) 2.22 kg CaCO3 per ton, along with their lack neutralization (NP), indicates a possibility for generation acid drainage (AMD). It was reported that concrete could be employed prevent AMD, thus we proposed stabilize...
Background and aims . It has been suggested that mitochondrial dysfunction is relevant to Alzheimer disease (AD) some haplogroups could be related the risk of AD. Therefore, in this work we have genotyped mtDNA Mexican patients with AD their respective matched controls. Methods: Haplotyping 33 49 healthy control subjects was performed using polymerase chain reaction/digest identification key polymorphic sites genome. Results: Mitochondrial haplogroup A most frequent controls followed by B....