A5005801444- Natural Compounds in Disease Treatment
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Epilepsy research and treatment
- Computational Drug Discovery Methods
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Synthesis of Organic Compounds
- Biochemical and biochemical processes
- Multicomponent Synthesis of Heterocycles
- Cancer, Lipids, and Metabolism
- Pesticide and Herbicide Environmental Studies
- Pharmacogenetics and Drug Metabolism
- Piperaceae Chemical and Biological Studies
- Insect and Pesticide Research
- Insect Pest Control Strategies
- Weed Control and Herbicide Applications
- Nutrition, Genetics, and Disease
- Synthesis of Indole Derivatives
- Cancer Treatment and Pharmacology
- Archaeology and Cultural Heritage
- Chemical and Environmental Engineering Research
Saint Aloysius Gonzaga National University
2004-2025
Vassar College
2019
Canary Institute of Cancer Research
2009-2010
Universidad de Las Palmas de Gran Canaria
2010
Universidad de La Laguna
1997-2008
Instituto de Parasitología y Biomedicina "López - Neyra"
2008
Consejo Superior de Investigaciones Científicas
2008
Hospital Universitario Nuestra Señora de Candelaria
2008
Hospital Universitario Dr José Eleuterio Gonzalez
2007
On the basis of previous pharmacophore modeling studies naphthoquinones derivatives, we have designed and synthesized a new set pyranonaphthoquinones. These compounds were obtained through direct highly efficient approach based on an intramolecular domino Knoevenagel hetero Diels−Alder reaction from lawsone (2-hydroxynaphthoquinone) variety aldehydes containing alkene. The pyranonaphthoquinones evaluated against α isoform human topoisomerase II (hTopoIIα). Among 11 derivatives studied, found...
The major production of artisanal and industrial wines is elaborate in the Ica Valley, Peru. objective was to evaluate antioxidant activity polyphenols permissible values glyphosate from Pisco Routes Samples: six coded two commercial brands as references (60088 60089). Total polyphenol content (TPC) found between 107.90 ± 0.30 (60091) 234.73 0.61 mg GAE/100 mL (60084); total flavonoid (TFC) 9.70 16.83 0.25 QE/100 (60084). Antioxidant activity: DPPH 34.9 0.44 55.6 mM TEAC/100 (60085). FRAP...
The CYP1A1 isoenzyme is responsible for the biotransformation of procarcinogens, such as Benzo(a)pyrene, into reactive metabolites. Meanwhile, GSTM1 facilitates detoxification these metabolites by conjugating them with glutathione. presence CYP1A1*2A genetic variant intensifies production metabolites, and deletion gene ( GSTM1*0 ) impairs their detoxification. This enzymatic imbalance leads to formation DNA adducts, which are known contribute cancer other diseases. Given importance studying...
Petroselinum crispum (Mill) Fuss is an aromatic plant belonging to the Apiaceae family and used in gastronomy as a spice. Several studies have been developed leaves but are limited seeds, especially essential oils obtained from seeds. The aim of this study was determine phytochemical profile volatile compounds oil by gas-chromatography-mass spectrometry (GC-MS) order evaluate its phytotoxic activity on Lactuca sativa seeds carry out silico analysis target enzyme herbicide glyphosate...
Schinus molle is a medicinal plant used as an anti-inflammatory and for rheumatic pain in the traditional medicine of Peru. On other hand, Aedes aegypti main vector several tropical diseases transmitter yellow fever, chikungunya, malaria, dengue, Zika virus. In this study, aim was to investigate antioxidant activity vitro insecticidal silico, presence mosquito juvenile hormone-binding protein (mJHBP) from aegypti, essential oil S. leaves. The volatile phytochemicals were analyzed by gas...
We have synthesized a set of bis-pyranobenzoquinones through direct and highly efficient approach based on double intramolecular domino Knoevenagel hetero Diels−Alder reaction. These bis-pyranobenzoquinone derivatives are compounds whose skeletons similarities to those some anticancerous leishmanicidal drugs. Considering that these drugs substrates for members the ATP-binding cassette (ABC) family proteins confers multidrug resistance (MDR) phenotype, we carried out biological evaluation 20...
Seven new triterpenoids (1−7) and 36 known compounds were isolated from the root bark of Maytenus retusa. Their structures determined by 1D 2D spectroscopic studies. Several evaluated for their cytotoxicity against human tumor cell lines HL-60 MCF-7. Some them cytotoxic, with IC50 values ranging between 0.2 4.7 μM.
A set of friedelane triterpenoids has been isolated from the stem bark exudates Maytenus macrocarpa. It includes a new friedelan triterpene (1), together with known compounds friedelin, 3-oxo-29-hydroxyfriedelane, 3-oxofriedelan-25-al, and canophyllol. The structures these were elucidated by spectroscopic chemical evidence. Complete 1H 13C assignments achieved 2D NMR spectroscopy. compound showed weak activity against aldose reductase. did not display antitumor P-388 lymphoid neoplasm, A-549...
The SARS-CoV-2 Omicron variant has spread rapidly and is considered the predominant in world, its main characteristic related to evade immunity from natural infection or vaccines, due multiple mutations spike protein. On other hand, medicinal plants have been used as alternatives therapies ameliorate some signs symptoms COVID-19, our previous work, cat’s claw (Uncaria tomentosa) stem bark studied vitro showed antiviral activity on well silico studies 3CLpro protein disruptor between ACE-2...
Heliotropium arborescens (Galán de Mera et al. 2022) is a herbaceous plant that contains various biophenolic compounds exhibit antibacterial property and antioxidant activity could prevent diseases caused by free radicals. The objective was to study the metal ions associated with in vitro of ethanolic extract L. leaves from Andean region Ayacucho-Peru. total polyphenolic content (TPC) determined Folin-Ciocalteu method; Total flavonoid (TFC) spectrophotometry at 510 nm, TFC expressed mg...
Context: Acute inflammation due to persistent stimulation of noxes evolves into chronic that contributes the pathogenesis asthma, arthritis, atherosclerosis, diabetes, aging, and cancer; therefore, it is justified study plants with anti-inflammatory activity fewer adverse effects. Aims: To evaluate potential effect total flavonoid content hydroalcoholic extract leaves Senna alata (L.) Roxb (HELSA) in an experimental model acute induced by carrageenan rats. Methods: The (TFC) was determined...
Piper acutifolium Ruiz & Pav is known as "matico" and belongs to the Piperaceae family, in Peru it traditionally used an infusion or decoction ameliorate wound healings ulcers. In this study, aim was investigate volatile components, antioxidant profile, phytotoxic activity of essential oil (EO) P. from Peru. To identify phytoconstituents, EO injected into a Gas Chromatography-Mass Spectrometry (GC-MS) obtain chemical profile followed by carried out reaction with three organic radicals...
Colorectal cancer (CRC) is the third most common diagnosed worldwide and second leading cause of cancer-related death due to an insufficiency prognosis generally in last step development. The Peruvian flora has a wide variety medicinal plants with therapeutic potential several diseases. Dodonaea viscosa Jacq. plant used treat inflammatory process as well gastrointestinal aim this study was examine cytotoxic, antiproliferative, cell death-inducing effects D. on colorectal cells (SW480 SW620)....
Five new triterpenes (1−5) and one lignan (6) were isolated from the aerial parts of Maytenus apurimacensis. Their structures determined on basis spectroscopic studies, including homonuclear heteronuclear correlation NMR experiments (COSY, ROESY, HSQC, HMBC).
Two new dammarane triterpenes have been isolated from the stem bark exudates of Maytenus macrocarpa. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies as 24(Z)-3-oxodammara-20(21),24-dien-27-oic acid (1) octa-nor-13-hydroxydammara-1-en-3,17-dione (2). These compounds tested for antitumoral activity.
Carbamazepine is a drug with narrow therapeutic range that requires clinical monitoring, since its toxic effects are not easily predictable, and the level can vary. Our study aimed to monitor serum determine concentration/dose relationship of carbamazepine in people epilepsy, analyzing implication. It observed 90.48% volunteers present values (4.3–10.4 mg/L) within (4–12 mg/L); 7.14% supratherapeutic levels (12.7–14.4 mg/L), 2.38% subtherapeutic (0.93 mg/L). The findings indicate negative...
Various properties are attributed to “maca”, including immunomodulatory due its secondary metabolites such as macamides, glucosinolates, isothiocyanates and flavonoids. Immunosuppression, hemolytic anemia, thymic involution were induced with cyclophosphamide. Three concentrations of doses dehydrated hydroalcoholic extract purple maca (EHADM) used for 30 days, the analysis variance Duncan’s multiple comparisons test results statistically significant (p<.05) which shows...
Context: Calcareous chitin, chitosan, and their modifications are used as bioadsorbents of metals dyes that cause environmental pollution, endocrine disruption, human diseases. Aims: To evaluate the selective bioadsorption silver ions (Ag+) by calcareous chitosan. Methods: Experimental prospective study. The presence functional groups was identified Fourier-transformed infrared spectroscopy (FT-IR), 1H-NMR scanning electron microscopy (SEM). Langmuir, Freundlich, Elovich models were applied...