A5072641659- Trypanosoma species research and implications
- Ubiquitin and proteasome pathways
- Pharmacogenetics and Drug Metabolism
- DNA Repair Mechanisms
- Weed Control and Herbicide Applications
- Research on Leishmaniasis Studies
- Neurobiology and Insect Physiology Research
- Schizophrenia research and treatment
- Nutrition, Genetics, and Disease
- Eicosanoids and Hypertension Pharmacology
- Mosquito-borne diseases and control
- Peptidase Inhibition and Analysis
- Glioma Diagnosis and Treatment
- Biofuel production and bioconversion
- Pharmacological Effects and Toxicity Studies
- Pesticide and Herbicide Environmental Studies
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Insect and Pesticide Research
- Plant-based Medicinal Research
- Parasite Biology and Host Interactions
- Pharmaceutical studies and practices
- Biochemical and Molecular Research
- Pharmacology and Obesity Treatment
- Genetics and Neurodevelopmental Disorders
Peruvian University of Applied Sciences
2025
Universidad San Ignacio de Loyola
2022
Universidade de São Paulo
2010-2021
Instituto Butantan
2015-2016
The major production of artisanal and industrial wines is elaborate in the Ica Valley, Peru. objective was to evaluate antioxidant activity polyphenols permissible values glyphosate from Pisco Routes Samples: six coded two commercial brands as references (60088 60089). Total polyphenol content (TPC) found between 107.90 ± 0.30 (60091) 234.73 0.61 mg GAE/100 mL (60084); total flavonoid (TFC) 9.70 16.83 0.25 QE/100 (60084). Antioxidant activity: DPPH 34.9 0.44 55.6 mM TEAC/100 (60085). FRAP...
The CYP1A1 isoenzyme is responsible for the biotransformation of procarcinogens, such as Benzo(a)pyrene, into reactive metabolites. Meanwhile, GSTM1 facilitates detoxification these metabolites by conjugating them with glutathione. presence CYP1A1*2A genetic variant intensifies production metabolites, and deletion gene ( GSTM1*0 ) impairs their detoxification. This enzymatic imbalance leads to formation DNA adducts, which are known contribute cancer other diseases. Given importance studying...
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a classical metabolic enzyme involved in energy production and plays role additional nuclear functions, including transcriptional control, recognition of misincorporated nucleotides DNA maintenance telomere structure. Here, we show that the recombinant protein T. cruzi GAPDH (rTcGAPDH) binds single-stranded telomeric DNA. We demonstrate binding to correlates with balance between oxidized reduced forms nicotinamide adenine dinucleotides...
Chromatin associated proteins are key regulators of many important processes in the cell. Trypanosoma cruzi, a protozoa flagellate that causes Chagas disease, alternates between replicative and nonreplicative forms accompanied by shift on global transcription levels changes its chromatin architecture. Here, we investigated T. cruzi proteome using three different protocols compared it (epimastigote) (trypomastigote) high-resolution mass spectrometry. More than 2000 were identified quantified...
Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1−/−) described showing that they are viable, have estrus cycle, fertility, a number puppies per litter similar wild type (WT). In specific brain regions, THOP1-/- exhibit altered mRNA expression proteasome beta5, serotonin 5HT2a receptor dopamine D2 receptor, but not neurolysin (NLN). Peptidomic...
Risperidone/olanzapine are antipsychotics used in Peru to control symptoms of psychosis. The objective was review the available evidence on potential pharmacokinetic interactions mediated by CYP1A2 and CYP2D6 polymorphic genes between risperidone or olanzapine selected drugs for treatment COVID-19. A bibliographic search conducted SciELO PubMed/Medline. selection criteria included all types articles English Spanish languages. In this review, CYP1A2/CYP2D6/CYP3A4 that encode their respective...
In clinical practice, therapeutic drug monitoring (TDM) makes it possible to measure the concentration of drugs in serum or saliva, purpose which is reduce adverse effects and optimize pharmacological therapy. The objective was determine concentrations Phenytoin saliva people with epilepsy. Cross-sectional, descriptive study dynamic recruitment 30 epilepsy (n = 30; 17 men, 56.7% 13 women, 43.3%; mean age 33.9 ± 11.83 years). Serum samples were collected at trough levels from patients, who...
Precision medicine seeks to individualize the dose from beginning of phar-macological therapy based on characteristics each patient, genes involved in metabolic phenotype, ethnicity or miscegenation, with purpose minimize adverse effects and optimize drug efficacy. The objective was re-view studies that describe association CYP2D6 CYP2C19 tricontinental Latin American ancestry Peruvians. A biblio-graphic search carried out PubMed/Medline SciELO, various descriptors Spanish English. results...
Intracellular peptides were shown to derive from proteasomal degradation of proteins mammalian and yeast cells, being suggested play distinctive roles both inside outside these cells. Here, the role intracellular previously identified skeletal muscle adipose tissues C57BL6/N wild type (WT) neurolysin knockout mice investigated. In differentiated C2C12 mouse some like insulin activated expression several genes related contraction gluconeogenesis. One peptides, LASVSTVLTSKYR (Ric4; 600 µg/kg),...
High-flow non-invasive ventilation (NIV) devices reduce the morbidity and mortality of COVID-19. The objective was to evaluate use device with high-flow helmet CPAP designed in Peru patients severe acute respiratory syndrome (COVID-19) hospitalized emergency services five hospitals. Prospective multicenter cross-sectional observational study from hospitals July August 2020. 19 were recruited divided into two groups (G-1 n = 10; G-2 9) applying clinical gasometric parameters as indicators...