A5085571939- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Venomous Animal Envenomation and Studies
- Transcranial Magnetic Stimulation Studies
- Pain Management and Placebo Effect
- Botulinum Toxin and Related Neurological Disorders
- Laser Applications in Dentistry and Medicine
- S100 Proteins and Annexins
- Cannabis and Cannabinoid Research
- Marine Invertebrate Physiology and Ecology
- Sleep and Wakefulness Research
- Healthcare and Venom Research
- Neuroscience and Neural Engineering
- Acupuncture Treatment Research Studies
- Pediatric Pain Management Techniques
- Neuroendocrine regulation and behavior
- Biochemical effects in animals
- Neurological disorders and treatments
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Pain Management and Treatment
- Bee Products Chemical Analysis
- Blood transfusion and management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Universidade de São Paulo
2016-2025
Centro Universitário das Faculdades Metropolitanas Unidas
2025
Secretaria do Meio Ambiente
2022
Hispanics in Philanthropy
2022
Instituto do Câncer do Estado de São Paulo
2019
Hospital Sírio-Libanês
2008-2013
Hospital São Paulo
2010-2013
Insper
2009-2012
Centre de Physiopathologie de Toulouse-Purpan
2009-2011
Inserm
2009-2011
To date, the endogenous ligands described for cannabinoid receptors have been derived from membrane lipids. identify a peptide ligand CB(1) receptors, we used recently conformation-state sensitive antibodies and screened panel of peptides rodent brain or adipose tissue. This led to identification hemopressin (PVNFKFLSH) as that selectively binds receptors. We find is receptor-selective antagonist, because it able efficiently block signaling by but not other members family A G protein-coupled...
N-type calcium channels are essential mediators of spinal nociceptive transmission. The core subunit the channel is encoded by a single gene, and multiple isoforms can be generated alternate splicing. In particular, cell-specific inclusion an alternatively spliced exon 37a generates novel form that highly enriched in neurons and, as we show here, downregulated neuropathic pain model. Splice isoform-specific small interfering RNA silencing <i>in vivo</i> reveals containing specifically...
Motor cortex stimulation is generally suggested as a therapy for patients with chronic and refractory neuropathic pain. However, the mechanisms underlying its analgesic effects are still unknown. In previous study, we demonstrated that cortical increases nociceptive threshold of naive conscious rats opioid participation. present investigated neurocircuitry involved during antinociception induced by transdural motor in considering little known about relation between analgesia. The neuronal...
<h3>Objective</h3> To compare the analgesic effects of stimulation anterior cingulate cortex (ACC) or posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic (TMS) in patients with central neuropathic pain (CNP) after stroke spinal cord injury a randomized, double-blinded, sham-controlled, 3-arm parallel study. <h3>Methods</h3> Participants were randomly allocated into active PSI-rTMS, ACC-rTMS, sham-PSI-rTMS, sham-ACC-rTMS arms. Stimulations performed for...
Motor cortex stimulation (MCS) has been used to treat patients with neuropathic pain resistant other therapeutic approaches; however, the mechanisms of control by MCS are still not clearly understood. We have demonstrated that increases nociceptive threshold naive conscious rats, opioid participation. In present study, effect transdural on in rats subjected chronic constriction injury sciatic nerve was investigated. addition, pattern neuronal activation, evaluated Fos and Zif268 immunolabel,...
Abstract Lessons Learned Pregabalin is a medication that can decrease neuronal hyperexcitability, relieve neuropathic pain, and reach stable plasma levels after titration period of only few days. Its use during oxaliplatin infusions was not able to the incidence chronic, oxalipaltin-related compared with placebo. Background Patients colorectal cancer (CRC) receiving (OXA) develop acute chronic painful oxaliplatin-induced peripheral neuropathy (OXAIPN). Acute OXA-related neuropathies have...
Various toxins isolated from Bothrops snake venoms induce inflammatory reactions and have been claimed to contribute the severity of local symptoms present in this envenomation. Notwithstanding, relative participation serine proteases, metalloproteases phospholipases A2 reaction produced by crude is poorly understood. Herein, jararaca venom was treated with phenylmethanesulfonyl fluoride (PMSF), 1,10-phenanthroline (oPhe), or p-bromophenacyl-bromide (p-BPB) inhibit those classes enzymes,...
To evaluate changes in DNA methylation profiles patients with fibromyalgia (FM) compared to matched healthy controls (HCs). All individuals underwent full clinical and neurophysiological assessment by cortical excitability (CE) parameters measured transcranial magnetic stimulation. from the peripheral blood of FM (n = 24) HC were assessed using Illumina-HumanMethylation450 BeadChips. We identified 1610 differentially methylated positions (DMPs) displaying a nonrandom distribution regions...
Abstract Globally, 537 million people suffer from diabetes mellitus (DM), a condition often associated with sensory disturbances, wound development, and chronic pain, which significantly affects the quality of life imposes substantial economic burden. This study evaluated effects photobiomodulation (PBM) therapy on nociceptive changes in diabetic patients to understand pain manifestations explore PBM's molecular mechanisms healing. Twenty type 2 DM underwent clinical assessments, completed...
Abstract Our study aimed to explore the potential of Photobiomodulation (PBM) as a treatment for Tendinopathy (TP), chronic condition characterized by tendon degeneration, inflammation, and pain, which current options often yield unsatisfactory outcomes. PBM, utilizing low‐level laser, has shown promise in reducing inflammatory markers, stimulating cell proliferation, alleviating thus presenting itself promising alternative therapy TP. Using an experimental rat model tendinopathy, male...
Abstract An 11‐year‐old, female West Highland white terrier presenting cough, emesis, diarrhoea and hyporexia refractory to symptomatic treatment was subjected endoscopy showing increased palatine tonsil region. Biopsy findings revealed a carcinoma. Computed tomography also showed an right medial retropharyngeal lymph node dorsally related the wing of atlas causing periosteal reaction, complete fracture stylohyoid bone. After 20 days diagnosis, severe cervical pain started as some...