A5015957219- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Long-Term Effects of COVID-19
- Botulinum Toxin and Related Neurological Disorders
- Pain Management and Treatment
- COVID-19 Clinical Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- Migraine and Headache Studies
- Intensive Care Unit Cognitive Disorders
- Stroke Rehabilitation and Recovery
- Trigeminal Neuralgia and Treatments
- Pain Management and Placebo Effect
- Neurosurgical Procedures and Complications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Anesthesia and Pain Management
- Neurological Complications and Syndromes
- Pain Management and Opioid Use
- Sinusitis and nasal conditions
- Facial Nerve Paralysis Treatment and Research
- Healthcare during COVID-19 Pandemic
- Mercury impact and mitigation studies
- Spatial Neglect and Hemispheric Dysfunction
- Hallucinations in medical conditions
- Photodynamic Therapy Research Studies
Universidade de São Paulo
2012-2025
Instituto do Câncer do Estado de São Paulo
2020-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2017-2024
Hospital Universitário da Universidade de São Paulo
2021-2024
Valens Clinics
2023-2024
Hospital São Paulo
2023
Hospital Samaritano de São Paulo
2020
Abstract Background We assessed whether COVID‐19 is associated with de novo pain and chronic (CP). Methods This controlled cross‐sectional study was based on phone interviews of patients discharged from hospital after compared to the control group composed individuals hospitalized during same period due non‐COVID‐19 causes. Patients were classified as having previous CP ICD‐11/IASP criteria, (i.e. any new type pain, irrespective status before stay), persistent or recurring lasting more than...
ABSTRACT Background: More than one-third of COVID-19 patients present neurological symptoms ranging from anosmia to stroke and encephalopathy. Furthermore, pre-existing conditions may require special treatment be associated with worse outcomes. Notwithstanding, the role neurologists in is probably underrecognized. Objective: The aim this study was report reasons for requesting consultations by internists intensivists a COVID-19-dedicated hospital. Methods: This retrospective carried out at...
Widespread contamination of the Amazon basin with mercury has been reported to occur since at least mid-80s due heavy gold mining activity. Although initial studies have indicated that this may lead deleterious neurological consequences indigenous populations living in region, further research is needed better characterize burden such long-term exposure. With aim, a cross-sectional exploratory study conducted Yanomami population residing northern region. All participants underwent structured...
The activity profile of the posterior insula in neuropathic pain (NeP) remains largely unexplored. To address this and examine its modulation by somatosensory stimulation, we recorded local field potentials (LFP) awake patients with NeP undergoing deep brain stimulation (DBS) electrode implantation to posterior-superior (PSI) for analgesic purposes. Six (one woman; 32-45 years), experiencing refractory peripheral having previously responded non-invasive PSI underwent stereotactic DBS...
Despite affecting 2-4% of the population worldwide, fibromyalgia often remains refractory to treatment. Here we report first international randomised double-blind, sham-controlled trial developed assess efficacy repetitive transcranial magnetic stimulation (rTMS) as an add-on therapy for fibromyalgia. Women aged ≥18 yr with best available treatment were enrolled in Brazil, France, and Japan, 10 Hz motor cortex (M1) rTMS, 3000 pulses day-1, or sham stimulation. This included induction...
New-onset chronic pain has been acknowledged as part of the post-COVID-19 condition. However, available fine-grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described distinct temporal evolutions their epidemiological phenotypical features.A prospective cross-sectional study enrolled condition patients (i.e. who had persisting COVID-19-related symptoms over 30 days since first positive laboratory test), whose COVID-19 diagnosis...
Altered somatosensory processing in the posterior insula may play a role chronic pain development and contribute to Parkinson disease (PD)-related pain. Posterior-superior (PSI) repetitive transcranial magnetic stimulation (rTMS) has been demonstrated have analgesic effects among patients with some conditions. This study aimed at assessing efficacy of PSI-rTMS for treating PD-related
To describe the clinical, neurological, neuroimaging, and cerebrospinal fluid (CSF) findings associated with encephalopathy in patients admitted to a COVID-19 tertiary reference center. We retrospectively reviewed records of consecutive evaluated by consulting neurology team from March 30, 2020 through May 15, 2020. Fifty-five confirmed SARS-CoV-2 were included, 43 whom showed encephalopathy, further divided into mild, moderate, severe groups. Nineteen (44%) had undergone mechanical...
Cerebrovascular disease is one of the most important causes death and disability worldwide. The patient's inability to identify warning signs stroke substantially delays search for emergency services, which related directly a worse outcome. Thus, during 2011 Stroke Campaign in Brazil, survey was conducted lay population's knowledge with regard recognition, treatment, prevention stroke.This retrospective, cross-sectional, multicenter study held cities throughout southeastern Brazil.The...
Chronic pain is a frequent and burdensome nonmotor symptom of Parkinson's disease (PD). PD-related chronic can be classified as nociceptive, neuropathic, or nociplastic, the former being most subtype. However, differences in neurophysiologic profiles between these subtypes, their potential prognostic therapeutic implications have not been explored yet. This cross-sectional study on patients with PD (PwP)-related (ie, started was aggravated by PD). Subjects were assessed for clinical...
In this randomized, double-blind, parallel placebo-controlled clinical trial, we evaluated the efficacy of methadone as an add-on therapy for people with chronic neuropathic pain (NP). Eighty-six patients were randomly assigned to receive or placebo 8 weeks. The primary outcome was proportion participants achieving at least 30% relief from baseline using a 100-mm Visual Analogue Scale. Secondary outcomes included global impression change, NP symptoms, sleep quality, quality life,...
A 75-year-old right-handed woman presented to the emergency department with simultanagnosia and right unilateral optic ataxia. Moreover, patient had agraphia, acalculia, digital agnosia right-left disorientation, consistent complete Gerstmann's syndrome. This case highlights concurrence of syndrome ataxia in acute phase a left middle cerebral artery stroke.Uma paciente de 75 anos e destra se apresentou à sala emergência com quadro óptica direita. Além disso, tinha agrafia, desorientação...
It is not known whether cortical plastic changes reported in low-back pain (LBP) are present all etiologies of LBP. Here we report on the assessment patients with three LBP conditions: non-specific-LBP (ns-LBP), failed back surgery syndrome (FBSS), and sciatica (Sc).Patients underwent a standardized clinical pain, conditioned modulation (CPM), measures motor evoked potential (MEPs)-based corticospinal excitability (CE) by transcranial magnetic stimulation, including short interval...
Abstract Colorectal cancer is one of the most common oncological diseases. Chemotherapy usually recommended as an adjuvant treatment for stage-II, -III, and -IV tumors. Approximately 10% patients develop neuropathic pain after chemotherapy, they may remain refractory despite administration drugs that are commonly used to treat pain. Spinal cord stimulation a good option lower limbs, it should be trialed in with chemotherapy-induced peripheral neuropathy. We report case patient...
Abstract Objective To describe the clinical, neurological, neuroimaging and cerebrospinal fluid (CSF) findings associated with encephalopathy in patients admitted to a COVID-19 tertiary reference center. Methods We retrospectively reviewed records of consecutive evaluated by consulting neurology team from March 30, 2020 through May 15, 2020. Results Fifty-five confirmed SARS-CoV-2 were included, 43 whom showed encephalopathy, further divided into mild, moderate severe groups. Nineteen (44%)...
Parkinson disease (PD) affects up to 2% of the general population older than 65 years and is a major cause offunctional loss. Chronic pain common nonmotor symptom that 80% patients with (Pw) PD bothin prodromal phases during subsequent stages disease, negatively affecting patient’s quality lifeand function. Pain in PwPD rather heterogeneous may occur because different mechanisms. Targetingmotor symptoms by dopamine replacement or neuromodulatory approaches only partially control PD---related...
Introduction: Non-invasive neuromodulation is extensively researched and applied as a therapeutic strategy for neuropathic pain due to its analgesic properties. Despite numerous meta-analyses guidelines addressing this area, establishing optimal care practices individuals remains pivotal. Objective: To consolidate existing knowledge evidence regarding the use of non-invasive management, we conducted umbrella review (registration number CRD42021239577). Material methods: Employing PICO...
BACKGROUND: The posterior-superior insula (PSI) has emerged as a potential target for non-invasive brain stimulation (NIBS) in the treatment of peripheral neuropathic pain. However, current methods identifying PSI require expensive and time-consuming imaging neuronavigation. Here, we propose Fast-PSI method, novel approach based on craniometry intracranial Euclidean distances proportions comparisons between scalp landmarks, to swiftly accurately locate projection scalp. METHODS: Eleven...