Mariana Hiromi Manoel Oku

ORCID: 0000-0003-3677-9100
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About
Contact & Profiles
Research Areas
  • Long-Term Effects of COVID-19
  • COVID-19 Clinical Research Studies
  • Intensive Care Unit Cognitive Disorders
  • Neurological and metabolic disorders
  • Healthcare during COVID-19 Pandemic
  • Genomics and Rare Diseases
  • Pregnancy and preeclampsia studies
  • Folate and B Vitamins Research
  • Genetics and Neurodevelopmental Disorders
  • Neuroscience and Neuropharmacology Research
  • Myasthenia Gravis and Thymoma
  • Neurological Complications and Syndromes
  • Infectious Encephalopathies and Encephalitis
  • Psychosomatic Disorders and Their Treatments
  • Genetic Neurodegenerative Diseases
  • Neurological disorders and treatments

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2020-2022

Universidade de São Paulo
2020

Higashi Osaka City General Hospital
2009

ABSTRACT Background: More than one-third of COVID-19 patients present neurological symptoms ranging from anosmia to stroke and encephalopathy. Furthermore, pre-existing conditions may require special treatment be associated with worse outcomes. Notwithstanding, the role neurologists in is probably underrecognized. Objective: The aim this study was report reasons for requesting consultations by internists intensivists a COVID-19-dedicated hospital. Methods: This retrospective carried out at...

10.1590/0004-282x20200089 article EN Arquivos de Neuro-Psiquiatria 2020-07-16

To describe the clinical, neurological, neuroimaging, and cerebrospinal fluid (CSF) findings associated with encephalopathy in patients admitted to a COVID-19 tertiary reference center. We retrospectively reviewed records of consecutive evaluated by consulting neurology team from March 30, 2020 through May 15, 2020. Fifty-five confirmed SARS-CoV-2 were included, 43 whom showed encephalopathy, further divided into mild, moderate, severe groups. Nineteen (44%) had undergone mechanical...

10.1007/s10072-020-04946-w article EN other-oa Neurological Sciences 2021-01-07

In about a third of the patients with epilepsy seizures are not drug-controlled. The current limitation antiepileptic drug therapy derives from an insufficient understanding pathophysiology. order to overcome this situation, it is necessary consider as disturbed network interactions, instead just looking for changes in single molecular components. Here, we studied CA3 transcriptional signatures and dentate gyrus histopathologic alterations hippocampal explants surgically obtained 57 RMTLE...

10.1038/s41598-021-89802-3 article EN cc-by Scientific Reports 2021-05-13

Abstract Objective To describe the clinical, neurological, neuroimaging and cerebrospinal fluid (CSF) findings associated with encephalopathy in patients admitted to a COVID-19 tertiary reference center. Methods We retrospectively reviewed records of consecutive evaluated by consulting neurology team from March 30, 2020 through May 15, 2020. Results Fifty-five confirmed SARS-CoV-2 were included, 43 whom showed encephalopathy, further divided into mild, moderate severe groups. Nineteen (44%)...

10.1101/2020.08.28.20181883 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2020-09-01

A 52-year-old immunocompetent man presented with a 2-month history of weight loss, fever, and headache associated cutaneous lesions in his face upper limbs. month later, he developed left-sided hemichorea (Video 1). Laboratory investigation revealed positive serum cryptococcal antigen hemagglutination test. Skin lung biopsies identified Cryptococcus gattii . Brain MRI showed right caudate internal capsule T2/FLAIR hyperintense compatible cryptococcomas (Figure). Cryptococcal infections...

10.1212/wnl.0000000000200710 article EN Neurology 2022-05-06
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