A5052153640- Nanoparticle-Based Drug Delivery
- Iron oxide chemistry and applications
- Iron Metabolism and Disorders
- Advanced X-ray and CT Imaging
- Mercury impact and mitigation studies
- Advanced MRI Techniques and Applications
- Advanced Sensor and Energy Harvesting Materials
- Escherichia coli research studies
- Folate and B Vitamins Research
- Lanthanide and Transition Metal Complexes
- Characterization and Applications of Magnetic Nanoparticles
- Inflammation biomarkers and pathways
- Graphene research and applications
- Immune cells in cancer
- Radiation Therapy and Dosimetry
- MRI in cancer diagnosis
- Chemistry Education and Research
- Bacterial Infections and Vaccines
- Lipid Membrane Structure and Behavior
- Advanced Drug Delivery Systems
- Heavy Metal Exposure and Toxicity
- Advanced Radiotherapy Techniques
- Advanced Materials and Mechanics
- Electrical and Thermal Properties of Materials
- Nanomaterials and Printing Technologies
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2024
Universidade de São Paulo
2016-2023
Instituto Butantan
2016
Widespread contamination of the Amazon basin with mercury has been reported to occur since at least mid-80s due heavy gold mining activity. Although initial studies have indicated that this may lead deleterious neurological consequences indigenous populations living in region, further research is needed better characterize burden such long-term exposure. With aim, a cross-sectional exploratory study conducted Yanomami population residing northern region. All participants underwent structured...
Nanostructured contrast agents are promising alternatives to Gd3+-based chelates in magnetic resonance (MR) imaging techniques. A novel ultrasmall paramagnetic nanoparticle (UPN) was strategically designed maximize the number of exposed sites and r1 while minimizing r2, by decorating 3 nm titanium dioxide nanoparticles with suitable amounts iron oxide. Its relaxometric parameters comparable those gadoteric acid (GA) agar phantoms, r2/r1 ratio 1.38 at T is close ideal unitary value. The...
Graphene oxide (GO) microfibers with controlled and homogeneous shapes tunable diameters were fabricated using the 3 dimensional (3D) hydrodynamic focusing concept on a microfluidic device.
Aim: To develop a series of superparamagnetic iron oxide nanoparticles (SPIONs) by coconjugating them with ibuprofen (ibu) and glycerol phosphate (glycerol) or ibu glucose-1-phosphate to assess capacity these conjugates inhibit the release nitric (NO) in macrophages, even at low concentrations. Materials & methods: The SPION were characterized their properties evaluated showing influence those ligands on colloidal stability inhibition NO-release demonstrated. cytotoxicity possible...
Aim: The low solubility and consequent poor bioavailability of ibuprofen (IBU) is a major drawback that can be overcome by anchoring IBU on ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) as effective multifunctional carriers for drug delivery. Methods: USPIONs were conjugated with glycerol phosphate (USPION-GP) also co-conjugated (USPION-GP/IBU), their in vivo toxicity anti-inflammatory effects investigated. Phosphate buffer saline (control), IBU, USPION-GP USPION-GP/IBU...
A systematic study was carried out to evaluate the uptake and cytotoxicity of methotrexate (MTX) conjugated superparamagnetic iron oxide nanoparticles (SPIONs) modified with glycerol phosphate (Glyc) phosphorylethanolamine (PEA), using MCF-7 cancer cell line as model. The ligand shell composition controlled in such a way get SPIONs nine different surface functionalization up three co-conjugated ligands but very core, order test compare cytotoxicity, verify possible additive effects. Folic...
Nanostructured contrast agents are promising alternatives to Gd(III)-based chelates in magnetic resonance (MR) imaging techniques. A novel ultrasmall paramagnetic nanoparticle (UPN) was strategically designed maximize the number of exposed sites and r1 while minimizing r2, by decorating 3 nm large titanium dioxide nanoparticles with suitable amounts iron oxide. Its relaxometric parameters comparable that gadoteric acid (GA) agar phantoms, r2/r1 ratio 1.38 at 3T is close ideal unitary value....