A5008956777- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Retinal Imaging and Analysis
- MRI in cancer diagnosis
- Retinal Diseases and Treatments
- Folate and B Vitamins Research
- Lanthanide and Transition Metal Complexes
- Nanoparticles: synthesis and applications
- Characterization and Applications of Magnetic Nanoparticles
- Retinal and Optic Conditions
- Chronic Myeloid Leukemia Treatments
- Slime Mold and Myxomycetes Research
- Biocrusts and Microbial Ecology
- Advanced MRI Techniques and Applications
Universidade de São Paulo
2019-2024
Instituto Butantan
2024
Nanostructured contrast agents are promising alternatives to Gd3+-based chelates in magnetic resonance (MR) imaging techniques. A novel ultrasmall paramagnetic nanoparticle (UPN) was strategically designed maximize the number of exposed sites and r1 while minimizing r2, by decorating 3 nm titanium dioxide nanoparticles with suitable amounts iron oxide. Its relaxometric parameters comparable those gadoteric acid (GA) agar phantoms, r2/r1 ratio 1.38 at T is close ideal unitary value. The...
Currently, cancer is among the most challenging diseases due to its ability continuously evolve into a more complex muldimentional system, in addition high capability spread other organs and tissues. In this context, relevance of nanobiomaterials (NBMs) for development new effective less harmful treatments increasing. NBMs provide possibility combining several functionalities on single expectedly synergic way, better perform treatment cure. However, control properties such as colloidal...
A systematic study was carried out to evaluate the uptake and cytotoxicity of methotrexate (MTX) conjugated superparamagnetic iron oxide nanoparticles (SPIONs) modified with glycerol phosphate (Glyc) phosphorylethanolamine (PEA), using MCF-7 cancer cell line as model. The ligand shell composition controlled in such a way get SPIONs nine different surface functionalization up three co-conjugated ligands but very core, order test compare cytotoxicity, verify possible additive effects. Folic...
Nanostructured contrast agents are promising alternatives to Gd(III)-based chelates in magnetic resonance (MR) imaging techniques. A novel ultrasmall paramagnetic nanoparticle (UPN) was strategically designed maximize the number of exposed sites and r1 while minimizing r2, by decorating 3 nm large titanium dioxide nanoparticles with suitable amounts iron oxide. Its relaxometric parameters comparable that gadoteric acid (GA) agar phantoms, r2/r1 ratio 1.38 at 3T is close ideal unitary value....