A5081154409- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Pain Management and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Pain Management and Placebo Effect
- Cancer Treatment and Pharmacology
- Health disparities and outcomes
- Vestibular and auditory disorders
- Stroke Rehabilitation and Recovery
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Trigeminal Neuralgia and Treatments
- Traumatic Brain Injury Research
- Migraine and Headache Studies
- Anesthesia and Pain Management
- Nerve Injury and Rehabilitation
- Pain Management and Opioid Use
- Aging, Elder Care, and Social Issues
- Health, Nursing, Elderly Care
- Aging and Gerontology Research
- Spinal Cord Injury Research
Universidade de São Paulo
2015-2024
Universidade Cidade de São Paulo
2016-2023
Instituto do Câncer do Estado de São Paulo
2015-2021
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011-2021
Universidade Federal do ABC
2020-2021
Centro Universitário Fundação Santo André
2021
Hospital Universitário da Universidade de São Paulo
2012-2020
Spaulding Rehabilitation Hospital
2019
Harvard University
2019
Universidade Federal do Amazonas
2019
To prospectively evaluate the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on different characteristics pain and other nonmotor symptoms (NMS) in patients with Parkinson disease (PD).Forty-four PD refractory motor were screened for STN-DBS. Patients evaluated before 1 year after surgery. The primary outcome was change prevalence Secondary measures changes function (Unified Parkinson's Disease Rating Scale), NMS using specific scales questionnaires, quality life.Forty-one...
<h3>Objective</h3> To compare the analgesic effects of stimulation anterior cingulate cortex (ACC) or posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic (TMS) in patients with central neuropathic pain (CNP) after stroke spinal cord injury a randomized, double-blinded, sham-controlled, 3-arm parallel study. <h3>Methods</h3> Participants were randomly allocated into active PSI-rTMS, ACC-rTMS, sham-PSI-rTMS, sham-ACC-rTMS arms. Stimulations performed for...
The cerebrocerebellum receives input from the cerebral cortex and projects to motor premotor cortices ventrolateral nucleus of thalamus via dentate (DN). Dentothalamocortical projections modulate activity contralateral primary (M1) are involved in movement planning. Acute ischemic injury cerebellar nuclei leads ataxia a loss physiologic excitatory inputs DN M1 cortex.1 However, chronic lesions have been associated with reemerging decrease intracortical inhibition (ICI) contralesional M1,...
Abstract Lessons Learned Pregabalin is a medication that can decrease neuronal hyperexcitability, relieve neuropathic pain, and reach stable plasma levels after titration period of only few days. Its use during oxaliplatin infusions was not able to the incidence chronic, oxalipaltin-related compared with placebo. Background Patients colorectal cancer (CRC) receiving (OXA) develop acute chronic painful oxaliplatin-induced peripheral neuropathy (OXAIPN). Acute OXA-related neuropathies have...
Motor cortex stimulation via surgically implanted electrodes has been used as an off-label treatment for chronic neuropathic pain, but its efficacy not fully established. We aimed to objectively study the of motor and characterize potential predictors response. In this randomized, double-blind, sham-controlled, single centre trial, we recruited 18 patients with pain who did adequately respond conventional had a numerical rating scale (NRS) score ≥6. Patients were initially assigned receive 3...
The effects of deep brain stimulation the subthalamic nucleus on nonmotor symptoms Parkinson's disease (PD) rarely have been investigated. Among these, sensory disturbances, including chronic pain (CP), are frequent in these patients. aim this study was to evaluate changes induced by perception stimuli, either noxious or innocuous, mediated small large nerve fibers. Sensory detection and thresholds were assessed 25 PD patients all off-medication condition with stimulator turned off (on-...
It has been shown that different symptoms or symptom combinations of neuropathic pain (NeP) may correspond to mechanistic backgrounds and respond differently treatment. The Neuropathic Pain Symptom Inventory (NPSI) is able detect distinct clusters (i.e. dimensions) with a putative common background. present study described the psychometric validation Portuguese version (PV) NPSI.Patients were seen in two consecutive visits, three four weeks apart. They asked to: (i) rate their mean intensity...
To evaluate changes in DNA methylation profiles patients with fibromyalgia (FM) compared to matched healthy controls (HCs). All individuals underwent full clinical and neurophysiological assessment by cortical excitability (CE) parameters measured transcranial magnetic stimulation. from the peripheral blood of FM (n = 24) HC were assessed using Illumina-HumanMethylation450 BeadChips. We identified 1610 differentially methylated positions (DMPs) displaying a nonrandom distribution regions...
To determine whether high-frequency repetitive transcranial magnetic stimulation (rTMS) improves cognition in patients with severe traumatic brain injury.A single-center, randomized, double-blind, placebo-controlled study of rTMS was conducted aged 18-60 years chronic (>12 months postinjury) diffuse axonal injury (DAI). Patients were randomized to either a sham or real group 1:1 ratio. A 10-session protocol used 10-Hz over the left dorsolateral prefrontal cortex (DLPFC). Neuropsychological...
Este artigo enfoca diferentes concepções de envelhecimento bem-sucedido, enfatizando o processo como uma experiência heterogênea, que implica estratégias para a obtenção bem-estar e qualidade vida. Foram selecionados estudos valorizam parte do curso vida humano, papel da subjetividade auto-avaliação em saúde, conceitos-chave compreender saúde na velhice. Os dados literatura sugerem bem-sucedido valoriza percepção dos próprios idosos, protagonistas intervenções dotados julgamentos sobre Mesmo...
Abstract Central post-stroke pain affects up to 12% of stroke survivors and is notoriously refractory treatment. However, patients often suffer from other types non-neuropathic nature (musculoskeletal, inflammatory, complex regional) no head-to-head comparison their respective clinical somatosensory profiles has been performed so far. We compared 39 with definite central neuropathic two matched control groups: 32 exclusively developed after 31 not complaining pain. Patients underwent deep...