To determine whether high-frequency repetitive transcranial magnetic stimulation (rTMS) improves cognition in patients with severe traumatic brain injury.A single-center, randomized, double-blind, placebo-controlled study of rTMS was conducted aged 18-60 years chronic (>12 months postinjury) diffuse axonal injury (DAI). Patients were randomized to either a sham or real group 1:1 ratio. A 10-session protocol used 10-Hz over the left dorsolateral prefrontal cortex (DLPFC). Neuropsychological...

Repetitive Transcranial Magnetic Stimulation (rTMS) has been proposed as a new tool in neurological rehabilitation of victims traumatic brain injury (TBI). However, its usefulness to treat this condition never tested rigorously. The primary goal is conduct study protocol determine whether rTMS used cognitive TBI with diffuse axonal (DAI) safe instrument and if it enhances function recovery. Double-blind randomized controlled trial patients injury. Thirty-six will be either an active coil...

Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). The aim this study is evaluate inhibitory attentional control after 18 sessions active LLLT and compare the placebo group (sham LLLT). Our exploratory analysis will efficacy on verbal visuospatial episodic memory, executive functions (working fluency, processes), anxiety depressive symptoms compared sham group. A randomized...

Diffuse axonal injury (DAI) is a frequent mechanism of traumatic brain (TBI) that triggers sequence parenchymal changes progresses from focal shear injuries up to inflammatory response and delayed disconnection.The main purpose this study evaluate in the axonal/myelinic content volume 12 months after TBI correlate these with neuropsychological results.Patients DAI (n = 25) were scanned at three time points trauma (2, 6, months), total (TBV), gray matter volume, white (WMV) calculated each...

Background and objective: Diffuse axonal injury (DAI) induces a long-term process of brain atrophy cognitive deficits. The goal this study was to determine whether there are correlations between volume loss, microhaemorrhage load (MHL) neuropsychological performance during the first year after DAI.Methods: Twenty-four patients with moderate or severe DAI were evaluated at 2, 6 12 months post-injury. MHL 3 months, volumetry 3, months. trail making test (TMT) used evaluate executive function...

Introduction Deficits in episodic memory following traumatic brain injury (TBI) are common and affect independence activities of daily living. Transcranial direct current stimulation (tDCS) concurrent cognitive training may contribute to improve patients with TBI. Although previous studies have shown the potential tDCS cognition, benefits applied simultaneously participants neurological disorders inconsistent. This study aims (1) investigate whether active combined computer-assisted enhances...

ABSTRACT A five‐and‐a‐half‐year‐old girl started experiencing progressive left hemiparesis at age two and a half years. At five years four months she presenting clusters of asymmetric periodic epileptic spasms with no hypsarrhythmia. The ictal EEG showed periodic, constant stereotyped complexes. Serial brain imaging revealed atrophy the right hemisphere increased T2 signal on MRI. She underwent hemispherotomy, histological examination signs inflammation features focal cortical dysplasia...

Background: Diffuse axonal injury (DAI), a common cause of neurological sequelae in patients with traumatic brain (TBI), is considered one the most prevalent forms primary neuronal severe TBI. Cognitive deficits induced by DAI can persist over time, especially following moderate or injuries. The aim present study was to compare verbal fluency (VF) performance at 6 and 12 months after trauma same group DAI. Methods: Eighteen 17 healthy volunteers were enrolled. All participants had sustained...

Chronic hepatitis C virus (HCV) infection is associated with impairment of cognitive function and mood disorders. Our aim was to evaluate the impact sustained virological response (SVR) on disorders.A prospective exploratory one arm study conducted. Adult clinically compensated HVC patients were consecutively recruited before treatment interferon ribavirin for 24 48 weeks, according HCV genotype. Clinical, neurocognitive assessments using PRIME-MD BDI instruments performed at baseline, right...

Diffuse axonal injury (DAI) is prevalent in traumatic brain (TBI), and often associated with poor outcomes cognitive impairment, including memory deficits. Few studies have explored visual after TBI its relationship to executive functioning. Executive functioning crucial for remembering an object's location, operating devices, driving, route finding. We compared performance via the Rey-Osterrieth Complex Figure (ROCF) test 6 12 months DAI.In total, 40 patients (mean age 28.7 years; 87.5%...

Photobiomodulation describes the use of red or near-infrared light to stimulate regenerate tissue. It was discovered that wavelengths (800–900 nm) and (600 light-emitting diodes (LED) are able penetrate through scalp skull have potential improve subnormal cellular activity compromised brain Different experimental clinical studies were performed test LED therapy for traumatic injury (TBI) with promising results. One proposals this present study is develop different approaches maximize...

Background: Mild traumatic brain injury (MTBI) represents 70-80% of all treated injuries. A considerable proportion MTBI patients experience post-concussion symptoms for a prolonged period after MTBI, and these are diagnosed as persistent syndrome (PPCS). PPCS is defined range physical, cognitive emotional symptoms. However, memory executive dysfunction seems to be one the most debilitating Recently, non-invasive stimulation has been studied potential treatment method (TBI) patients....

Abstract Long-term trials are key to understanding chronic symptoms such as pain and itch. However, challenges high attrition rates poor recruitment common when conducting research. The aim of this work was explore these issues within a long-term randomized control trial using transcranial direct current stimulation treat This parallel double blinded, placebo-controlled comprised 15 visits 7 follow-up visits. Participants were over the age 18, had burn injury that occurred at least 3 weeks...

Background: Overactivation of NMDA-mediated excitatory processes and excess GABA-mediated inhibition are attributed to the acute subacute phases, respectively after a traumatic brain injury. However, there few studies regarding circuitry during chronic phase Objective: To evaluate cortical excitability (CE) injury (TBI) in victims diagnosed with diffuse axonal (DAI). Methods: The 22 adult subjects were evaluated minimum 1 year from onset moderate or severe TBI. Each first had comprehensive...

Background: Traumatic brain injury (TBI) is one of the leading causes neuropsychiatric disorders in young adults. Repetitive Transcranial Magnetic Stimulation (rTMS) has been shown to improve psychiatric symptoms other neurologic disorders, such as focal epilepsy, Parkinson's disease, and fibromyalgia. However, efficacy rTMS a treatment for anxiety persons with TBI never investigated. This exploratory post-hoc analyzes effects on anxiety, depression executive function participants moderate...

Hypnosis is a valuable tool in the management of patients who undergo surgical procedures maxillofacial complex, particularly reducing and eliminating pain during surgery aiding have dental fear are allergic to anesthesia. This case report demonstrates efficacy hypnosis mitigating anxiety, bleeding, without anesthesia implant placement tooth 14, upper left first molar.

Objective: The goal is to evaluate longitudinally with diffusion tensor imaging (DTI) the integrity of cerebral white matter in patients moderate and severe DAI correlate DTI findings cognitive deficits.Methods: Patients (n = 20) were scanned at three timepoints (2, 6 12 months) after trauma. A healthy control group was evaluated once same high-field MRI scanner. corpus callosum (CC) bilateral superior longitudinal fascicles (SLFs) assessed by deterministic tractography ExploreDTI....