A5048991368- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Balance, Gait, and Falls Prevention
- Dementia and Cognitive Impairment Research
- Hematopoietic Stem Cell Transplantation
- Nanoplatforms for cancer theranostics
- Cognitive Functions and Memory
- Traumatic Brain Injury Research
- Characterization and Applications of Magnetic Nanoparticles
- Diet and metabolism studies
- Cognitive Abilities and Testing
- EEG and Brain-Computer Interfaces
- Graphene and Nanomaterials Applications
- Visual perception and processing mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Injury Epidemiology and Prevention
- Motor Control and Adaptation
- Neurogenesis and neuroplasticity mechanisms
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2009-2024
Universidade de São Paulo
2013-2024
Amsterdam Neuroscience
2024
Amsterdam University Medical Centers
2024
Vrije Universiteit Amsterdam
2024
Hospital Israelita Albert Einstein
2021-2024
Hospital São Paulo
2023
Abstract Background Exercises with motor complexity induce neuroplasticity in individuals Parkinson's disease (PD), but its effects on freezing of gait are unknown. The objective this study was to verify if adapted resistance training instability — exercises will be more effective than traditional rehabilitation without improving freezing‐of‐gait severity, outcomes linked gait, and brain function. Methods Freezers were randomized either the group (n = 17) or active control (traditional...
Objective: To evaluate the magnetic hyperthermia therapy in glioblastoma tumor-on-a-Chip model using a microfluidics device. Methods: The nanoparticles coated with aminosilane were used for of hyperthermia, being evaluated specific absorption rate at 300 Gauss and 305kHz. A preculture C6 cells was performed before 3D culture on chip. process Chip after administration 20μL (10mgFe/mL) [...]
Magnetic hyperthermia (MHT) has been shown as a promising alternative therapy for glioblastoma (GBM) treatment. This study consists of three parts: The first part evaluates the heating potential aminosilane-coated superparamagnetic iron oxide nanoparticles (SPIONa). second and third parts comprise evaluation MHT multiple applications in GBM model, either vitro or vivo. obtained curves SPIONa (100 nm, +20 mV) their specific absorption rates (SAR) stablished best therapeutic conditions...
Objective: To evaluate the potential of magnetic hyperthermia using aminosilane-coated superparamagnetic iron oxide nanoparticles in glioblastoma tumor model. Methods: The were analyzed as to their stability aqueous medium and heating through specific absorption rate, when submitted with different frequencies intensities alternating field. In vitro assays, C6 cells cultured transduced luciferase by bioluminescence absence/presence [...]
The primary objective of this study is to monitor tumor growth by using image techniques and behavioral testing through general specific motor activities (spontaneous movements gait). Our sample includes male Wistar rats, 2 months old weighing 250–300 g, that categorized into three groups: control, sham, experimental. experimental group was anesthetized; the C6 cells with luciferase expression were suspended in a culture medium implanted right frontoparietal cortex rats. sham received...
Abstract The hippocampus is one of the earliest sites involved in pathology Alzheimer's disease (AD). Therefore, we specifically investigated sensitivity and specificity hippocampal volume glucose metabolism patients being evaluated for AD, using automated quantitative tools (NeuroQuant – magnetic resonance imaging [MRI] Scenium positron emission tomography [PET]) clinical evaluation. This retrospective study included adult over age 45 years with suspected who had undergone...
Specific impairments of anticipatory postural adjustment (APA) during step initiation have been reported in patients with Parkinson's disease (PD) and freezing gait (FoG). Although APA disruption has associated FoG, there is scarce knowledge about its neural correlates. We sought to better understand the networks involved FoG by assessing level hemodynamic response specific brain regions functional connectivity leg lifting task. In current investigation, APAs PD, without (nFoG) were assessed...
Diffuse axonal injury (DAI) is a frequent mechanism of traumatic brain (TBI) that triggers sequence parenchymal changes progresses from focal shear injuries up to inflammatory response and delayed disconnection.The main purpose this study evaluate in the axonal/myelinic content volume 12 months after TBI correlate these with neuropsychological results.Patients DAI (n = 25) were scanned at three time points trauma (2, 6, months), total (TBV), gray matter volume, white (WMV) calculated each...
Individuals with Parkinson’s disease (PD) and freezing of gait (FOG) have a loss presynaptic inhibition (PSI) during anticipatory postural adjustments (APAs) for step initiation. The mesencephalic locomotor region (MLR) has connections to the reticulospinal tract that mediates inhibitory interneurons responsible modulating PSI APAs. Here, we hypothesized MLR activity initiation would explain APAs in FOG (freezers). Freezers (n = 34) were assessed ON-medication state. We beta blood...
To evaluate the in vitro and vivo toxicities of polyethylene glycol-coated gold nanoparticles synthesized using a one-step process.
Background: Mnemonic strategy training (MST) has been shown to improve cognitive performance in amnestic mild impairment (a-MCI), however several questions remain unresolved. The goal of the present study was replicate earlier pilot findings using a randomized controlled design and evaluate transfer effects changes brain activation. Methods: Thirty patients with a-MCI were into MST or education program. At baseline, participants completed clinical neuropsychological assessments as well...
Abstract The purpose of this study was to review the use magnetic targeting technique, characterized by driving compounds based on superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery for a specific brain locus in gliomas. We reviewed process mediated application an external static field SPIONs A search PubMed, Cochrane Library, Scopus, and Web Science databases identified 228 studies, 23 which were selected inclusion criteria predetermined exclusion criteria. articles...
This in vitro study aims to evaluate the magnetic hyperthermia (MHT) technique and best strategy for internalization of nanoparticles coated with aminosilane (SPIONAmine) glioblastoma tumor cells. SPIONAmine 50 100 nm were used specific absorption rate (SAR) analysis, performing MHT intensities 50, 150, 300 Gauss frequencies varying between 305 557 kHz. The was performed using 100, 200, µgFe/mL SPIONAmine, or without Poly-L-Lysine (PLL) filter, static dynamic magnet field. cell viability...