A5072652338- Animal testing and alternatives
- Pluripotent Stem Cells Research
- Effects and risks of endocrine disrupting chemicals
- Immunotoxicology and immune responses
- Skin Protection and Aging
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Indoor Air Quality and Microbial Exposure
- Air Quality and Health Impacts
- Pain Mechanisms and Treatments
- Computational Drug Discovery Methods
- Bee Products Chemical Analysis
- Laser Applications in Dentistry and Medicine
Universidade de São Paulo
2017-2025
Different models of reconstructed human epidermis (RHE) are currently validated to assess skin irritation in vitro and ultimately the animal replacement Draize test. The development a new RHE model is challenge for many laboratories, representing potential gain autonomy improvement technological knowledge. Organization Economic Co-operation Development (OECD) encourages and, this purpose, offers thorough guideline on quality control parameters (OECD TG 439 performance standards). This work...
Abstract Globally, 537 million people suffer from diabetes mellitus (DM), a condition often associated with sensory disturbances, wound development, and chronic pain, which significantly affects the quality of life imposes substantial economic burden. This study evaluated effects photobiomodulation (PBM) therapy on nociceptive changes in diabetic patients to understand pain manifestations explore PBM's molecular mechanisms healing. Twenty type 2 DM underwent clinical assessments, completed...
Introduction: In skin traumas, such as burns, epidermal homeostasis is affected, often requiring clinical approaches. Different therapeutic strategies can be used including transplantation, besides the use of synthetic or natural materials with allogeneic cells. this context, tissue engineering an essential tool for regeneration, and using mesenchymal stem cells (MSC) from umbilical cord appears to a promising strategy in regenerative medicine due its renewal differentiation potential hypo...