A5023791789- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Hormonal Regulation and Hypertension
- Chromatin Remodeling and Cancer
- Renal and related cancers
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- PI3K/AKT/mTOR signaling in cancer
- Adipose Tissue and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Bee Products Chemical Analysis
- Retinoids in leukemia and cellular processes
- Pituitary Gland Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- Lymphoma Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Genetic Syndromes and Imprinting
- Adrenal Hormones and Disorders
- RNA modifications and cancer
- Laser Applications in Dentistry and Medicine
- Pain Mechanisms and Treatments
Universidade de São Paulo
2018-2025
Instituto Butantan
2024
Universidade Estadual de Londrina
2016-2019
Abstract Globally, 537 million people suffer from diabetes mellitus (DM), a condition often associated with sensory disturbances, wound development, and chronic pain, which significantly affects the quality of life imposes substantial economic burden. This study evaluated effects photobiomodulation (PBM) therapy on nociceptive changes in diabetic patients to understand pain manifestations explore PBM's molecular mechanisms healing. Twenty type 2 DM underwent clinical assessments, completed...
Colorectal Cancer (CRC) is the third most frequent type of cancer worldwide. In past few years, studies have revealed a protective effect metformin (MET-an anti-hyperglycemic drug, used to treat 2 diabetes), against CRC. The MET has been associated with AMPK activation (and mTOR inhibition), resulting in suppressed protein synthesis, and reduced cell proliferation malignant transformed cells. To elucidate new mechanisms for metformin, we evaluated oxidative stress inflammatory process...
New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in vitro effects of different chemotherapy drugs, alone or combined mitotane, on viability cells.Everolimus, sunitinib, zoledronic acid, imatinib nilotinib cytotoxicity, mitotane were tested ACC H295R cells monolayer spheroid cultures using MTS assays confocal microscopy. Moreover,...
With recent progress in understanding the pathogenesis of adrenocortical tumors (ACTs), identification molecular markers to predict their prognosis has become possible. TCF21/POD-1 is a transcriptional regulatory protein expressed mesenchymal cells at sites epithelial-mesenchymal transition during development different systems. Adult carcinomas express less TCF21 than adenomas; genes negatively correlated with include among others BUB1B KEGG (Encyclopedia and Genomes) pathway analysis. The...
Objective To analyze the morphological and functional characteristics of primary macronodular adrenal hyperplasia (PMAH) nodules carrying or not ARMC5 mutations consequences presence in terms pattern macronodule composition state. Subjects methods The analyses were performed by hematoxylin-eosin staining, immunohistochemistry, microdissection spongiocyte tissue RT-qPCR histological sections from 16 patients diagnosed with PMAH germline (5) germline/somatic without (6) gene. Results...
Transcription factor 21 (TCF21) directly binds and regulates SF1 mRNA expression in tumor normal adrenocortical cells, both are involved the development steroidogenesis of adrenal cortex.TCF21 is a suppressor gene its reduced malignant tumors.In tumors, it less expressed carcinomas (ACC) than adenomas (ACA) tissues.However, comprehensive analysis to identify TCF21 targets has not yet been conducted any type cancer.In this study, we performed Chromatin Immunoprecipitation Sequencing...
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This study analyzes the extracellular matrix (ECM) signatures of outer (OF = capsule + subcapsular zona glomerulosa cells) and inner fractions (IF fasciculata rat adrenal cortex, which comprise two distinct microenvironment niches. Proteomic profiles decellularized OF IF samples, male female rats, identified 252 proteins, with 32 classified as ECM-component ECM-related. Among these, 25 proteins were differentially regulated: 17 more abundant in OF, including Col1a1, Col1a2, Col6a1, Col6a2,...
The extracellular matrix (ECM) comprises macromolecules that shape a complex three-dimensional network. Filling the intercellular space and playing crucial role in structure function of tissues, ECM regulates essential cellular processes such as adhesion, differentiation, cell signaling. In human adrenal gland, composed cortex medulla surrounded by capsule, has not yet been directly described, although its impact on proliferation steroidogenesis is recognized. This study analyzes adult...
Abstract Transcription factor 21 (TCF21/POD-1/Epicardin) inhibits the expression of SF-1 (NR5A1) by binding to promoter E-box site in adrenocortical carcinoma (ACC). In contrast, TCF21 promotes increased LRH-1 hepatocarcinoma cell line, HepG2 cells, Small Heterodimer Partner (SHP/NR0B2) region, an negative regulator. Epigenetic alteration induced loss function and has been associated with cellular migration invasion. ACC, is hypermethylated less expressed. Our aim was evaluate effect...
Adrenocortical carcinomas (ACC) are rare and aggressive cancer. Our previous study has revealed that the transcription factor 21, TCF21, is downregulated in ACC regulates steroidogenic 1 (SF-1) binding to SF-1 E-box promoter. In addition, it could be found TCF21 a predictor of overall survival (OS) adult carcinomas.In this study, was investigated correlation between expression promoter methylation status adrenocortical tumor cells, adenoma. The biological function potential molecular...
Abstract Background: Adrenocortical carcinomas (ACC) are rare and aggressive cancer. Our previous study has revealed that the transcription factor 21, TCF21, is downregulated in ACC regulates steroidogenic 1 (SF-1) binding to SF-1 E-box promoter. In addition, it could be found TCF21 a predictor of Overall Survival (OS) adult carcinomas. Methods: this study, was investigated correlation between expression promoter methylation status adrenocortical tumor cells, adenoma. The biological function...