Milton Valderrama-Wong

ORCID: 0000-0002-3430-143X
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About
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Research Areas
  • COVID-19 Clinical Research Studies
  • Nutrition, Genetics, and Disease
  • Schizophrenia research and treatment
  • Organ Transplantation Techniques and Outcomes
  • Liver Disease and Transplantation
  • Genomics, phytochemicals, and oxidative stress
  • Pharmacogenetics and Drug Metabolism
  • Liver Disease Diagnosis and Treatment
  • Glutathione Transferases and Polymorphisms
  • Tryptophan and brain disorders
  • Pharmacological Receptor Mechanisms and Effects

Universidad San Ignacio de Loyola
2021-2022

Universidad Ricardo Palma
2019

The polymorphic variants of CYP1A1 and the deletion GSTM1 are present in Peruvian mestizo population. Wild type mutated genotypes (WT/*2A *2A/ *2A) were identified, whose allele frequencies 0.31 (T allele) 0.69 (C allele), respectively; 53% with wild (+) 47% null . frequency Iquiteño emigrants was 0.72 CYP1A1*2A 25% (-); from Lima 0.67 33% (-). Hardy-Weinberg equilibrium test for studied population showed that both out balance, p > .05. presence risk polymorphism gene high, which...

10.3897/pharmacia.68.e71621 article EN cc-by Pharmacia 2021-10-05

Risperidone/olanzapine are antipsychotics used in Peru to control symptoms of psychosis. The objective was review the available evidence on potential pharmacokinetic interactions mediated by CYP1A2 and CYP2D6 polymorphic genes between risperidone or olanzapine selected drugs for treatment COVID-19. A bibliographic search conducted SciELO PubMed/Medline. selection criteria included all types articles English Spanish languages. In this review, CYP1A2/CYP2D6/CYP3A4 that encode their respective...

10.2174/1872312815666221125112724 article EN Drug Metabolism and Bioanalysis Letters 2022-11-28

This study aims at understanding the vascularization of human liver to determine correct way divide it into "divisions" (sectors) and segments, for which we dissected 250 livers using acrylic resin injection method. The results showed role “Porta hepatis” in hepatic vascular distribution, existence seven pedicles portal fissures parenchymal division liver. Our research provides definition a segment demonstrates vein originating any division.

10.4067/s0717-95022020000100226 article EN International Journal of Morphology 2019-11-20
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