A5032548714- Attention Deficit Hyperactivity Disorder
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Cleft Lip and Palate Research
- Functional Brain Connectivity Studies
- Craniofacial Disorders and Treatments
- Epigenetics and DNA Methylation
- Migraine and Headache Studies
- Adolescent and Pediatric Healthcare
- Cognitive Abilities and Testing
- Child and Adolescent Psychosocial and Emotional Development
- Genetic and phenotypic traits in livestock
- Health disparities and outcomes
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Mental Health Research Topics
- Obesity, Physical Activity, Diet
- Maternal Mental Health During Pregnancy and Postpartum
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Genetic Mapping and Diversity in Plants and Animals
- Liver Disease Diagnosis and Treatment
University of Bristol
2016-2025
Medical Research Council
2015-2025
MRC Epidemiology Unit
2014-2023
Universidade de São Paulo
2023
At Bristol
2019-2022
Children's Hospital of Philadelphia
2022
University Of Bristol Dental Hospital
2016-2021
Cardiff University
2009-2021
Broad Institute
2020
Case Western Reserve University
2019
Schizophrenia is a highly heritable, polygenic condition characterized by relatively diverse phenotype and frequent comorbid conditions, such as anxiety depression. At present, limited evidence explains how genetic risk for schizophrenia manifest in the general population.
It is often assumed that selection (including participation and dropout) does not represent an important source of bias in genetic studies. However, there little evidence to date on the effect factors participation.Using data mothers (N = 7486) children 7508) from Avon Longitudinal Study Parents Children, we: (i) examined association polygenic risk scores for a range sociodemographic lifestyle characteristics health conditions related continued participation; (ii) investigated whether...
A major motivation for seeking disease-associated genetic variation is to identify novel risk processes. Although rare copy number variants (CNVs) appear contribute attention deficit hyperactivity disorder (ADHD), common (single-nucleotide polymorphisms [SNPs]) have not yet been detected using genome-wide association studies (GWAS). This raises the concern as whether future larger-scale, adequately powered GWAS will be worthwhile. The authors undertook a of ADHD and examined associated SNPs,...
Attention-deficit/hyperactivity disorder (ADHD) can be viewed as the extreme end of traits in general population. Epidemiological and twin studies suggest that ADHD frequently co-occurs with shares genetic susceptibility autism spectrum (ASD) ASD-related traits. The aims this study were to determine whether a composite common molecular variants, previously found associated clinically diagnosed ADHD, predicts population.Polygenic risk scores calculated Avon Longitudinal Study Parents Children...
OBJECTIVE Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk. There evidence aggression or conduct in children with ADHD indexes higher loading and clinical severity. The authors examine whether considered en masse as polygenic scores for are especially enriched comorbid disorder. METHOD Polygenic derived from an GWAS meta-analysis were calculated...
Depression is a common mental illness and research has focused on late childhood adolescence in an attempt to prevent or reduce later psychopathology and/or social impairments. It important establish study population-averaged trajectories of depressive symptoms across as this could characterise specific changes populations help identify critical points intervene with treatment. Multilevel growth-curve models were used explore adolescent 9301 individuals (57% female) from the Avon...
<h3>Importance</h3> Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental that shows clinical and genetic overlap with other childhood disorders. Levels of ADHD symptoms typically decline across adolescence, although they remain elevated for some individuals. The determinants symptom persistence are not yet fully understood. <h3>Objectives</h3> To test the hypothesis risk variant load (indexed by polygenic scores [PRS]), but psychiatric disorders, associated...
Mitochondria (MT), the major site of cellular energy production, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear (MT-nDNA). In CHARGEmtDNA+ Consortium, we studied associations mtDNA MT-nDNA with body mass index (BMI), waist-hip-ratio (WHR), glucose, insulin, HOMA-B, HOMA-IR, HbA1c. This 45-cohort collaboration comprised 70,775 (insulin) to 170,202 (BMI) pan-ancestry individuals. Validation imputation variants was followed single-variant gene-based...
<h3>Importance</h3> Acetaminophen (paracetamol) is used by a large proportion of pregnant women. Research suggests that acetaminophen use in pregnancy associated with abnormal fetal neurodevelopment. However, it possible this association might be confounded unmeasured behavioral factors linked to use. <h3>Objective</h3> To examine associations between offspring problems and (1) maternal prenatal use, (2) postnatal (3) partner’s <h3>Design, Setting, Participants</h3> From February 2015 March...
Progress has recently been made in understanding the genetic basis of schizophrenia and other psychiatric disorders. Longitudinal studies are complicated by participant dropout, which could be related to presence problems associated risk. We tested whether common variants implicated were with study nonparticipation among 7,867 children 7,850 mothers from Avon Study Parents Children (ALSPAC; 1991–2007), a longitudinal population cohort study. Higher polygenic risk scores for consistently...
Abstract Objectives To examine whether educational attainment and intelligence have causal effects on risk of Alzheimer’s disease (AD), independently each other. Design Two-sample univariable multivariable Mendelian randomization (MR) to estimate the education vice versa, total independent both AD risk. Participants 17 008 cases 37 154 controls from International Genomics Project (IGAP) consortium. Main outcome measure Odds ratio (OR) per standardized deviation increase in years schooling...
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common that influence fetal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10−6) birth length, which three were novel and four or near loci to be associated with height (LCORL, PTCH1, GPR126 HMGA2). The SNPs followed-up nine replication...
Objective Mendelian randomisation (MR) is a technique that aims to assess causal effects of exposures on disease outcomes. The paper present the main assumptions underlie MR, statistical methods used estimate and how account for potential violations key assumptions. Methods We discuss should be satisfied in an MR setting. list methodologies two-sample when summary data are available (ie, Wald ratio estimator, inverse-variance weighted maximum likelihood method) identify/adjust MR-Egger...
Background There is recent evidence of some degree shared genetic susceptibility between adult schizophrenia and childhood attention-deficit hyperactivity disorder (ADHD) for rare chromosomal variants. Aims To determine whether there overlap common alleles conferring risk in adults with those that do so ADHD children. Method We used recently published Psychiatric Genome-wide Association Study (GWAS) Consortium (PGC) data to define over-represented people tested were more 727 children than...
Early-life exposures, such as prenatal maternal lifestyle, illnesses, nutritional deficiencies, toxin levels, and adverse birth events, have long been considered potential risk factors for neurodevelopmental disorders in offspring. However, genetic could be confounding the association between early-life exposures outcomes offspring, which makes inferring a causal relationship problematic.
Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role epigenetic mechanisms in causing clefts or capturing information about genetic environmental factors. Given the evidence that different subtypes of cleft have distinct aetiologies, we explored whether children with showed profiles.In whole-blood samples from 150 Cleft Collective cohort study, measured DNA methylation at over 450,000 sites on genome. We then carried out epigenome-wide...
Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum (ASD) have been reported. Cross-trait relationships are, however, subject to dynamic changes during development. We investigated the continuity of overlap ASD ADHD in a general population sample childhood adolescence. also studied uni- cross-dimensional trait-disorder links with respect risk.Social-communication difficulties (N ≤ 5551, Social Communication Disorders Checklist, SCDC)...