A5080473673- Forensic and Genetic Research
- Blood groups and transfusion
- Race, Genetics, and Society
- Forensic Anthropology and Bioarchaeology Studies
- Erythrocyte Function and Pathophysiology
- Migration, Identity, and Health
- Neonatal Health and Biochemistry
- Historical Studies and Socio-cultural Analysis
- African Studies and Ethnography
- Archaeology and ancient environmental studies
- Genetic diversity and population structure
- Blood donation and transfusion practices
- Pleistocene-Era Hominins and Archaeology
- Indigenous Health and Education
- Genomics and Phylogenetic Studies
- Yersinia bacterium, plague, ectoparasites research
- Indigenous Studies and Ecology
- Blood disorders and treatments
- Agriculture and Rural Development Research
- Immunodeficiency and Autoimmune Disorders
- Healthcare Systems and Practices
- Genetic Associations and Epidemiology
- Global Maritime and Colonial Histories
- Hepatitis B Virus Studies
- Synthesis and characterization of novel inorganic/organometallic compounds
Centre National de la Recherche Scientifique
2010-2025
Aix-Marseille Université
2013-2025
Université Toulouse III - Paul Sabatier
2002-2020
Établissement Français du Sang
2018-2020
Université de Toulouse
2020
Laboratoire Hétérochimie Fondamentale et Appliquée
1999-2012
Laboratoire d'Anthropologie Sociale
2006
Despite being located at the crossroads of Asia, genetics Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset our samples, mitochondrial Y- chromosome data over 500 Afghan samples among these 5 groups. This was supplemented with same Y-chromosome analyses Iran, Kyrgyzstan, Mongolia updated Pakistani (HGDP-CEPH). The presented here integrated into...
A population in a natural crossroad within Europe reveals multiple ancient contributions and substantial structure.
Post-marital residence of spouses is one the architects population genetic structure. In present study, we tested how place males and females in Ngazidja, Comoros Islands, has unequally channeled, by dispersal among villages, male female diversity. Using sequences hypervariable segment I mitochondrial DNA (mtDNA HVS-I) six Y-chromosome microsatellites (Y-STRs), measured variation male-to-female effective number migrants ratios based on FST values revealed a structure mostly driven gene flow...
Despite the advances in paleogenomics, red cell blood group systems ancient human populations remain scarcely known. Pioneer attempts showed that Neandertal and Denisova, two archaic hominid inhabiting Eurasia, expressed groups currently found sub-Saharans a rare "rhesus", part of which is Oceanians. Herein we fully pictured genetic diversity 22 Homo sapiens 14 Neandertals from Eurasia living between 120,000 20,000 years before present (yBP). From ABO, Rh, Kell, Duffy, Kidd, MNS, Diego, H,...
Summary We report an integrated analysis of nuclear (autosomal, X‐ and Y‐chromosome) short tandem repeat (STR) data mtDNA D‐loop sequences obtained in the same set 22 Native populations from across Americas. A north to south gradient decreasing population diversity was observed, agreement with a settlement Americas extreme northwest continent. This correlation is stronger “least cost distances,” which consider coasts as facilitators migration. Continent‐wide estimates structure are highest...
Culture and genetics rely on two distinct but not isolated transmission systems. Cultural processes may change the human selective environment thereby affect which individuals survive reproduce. Here, we evaluated whether modes of subsistence in Native American populations frequencies ABCA1*Arg230Cys polymorphism were correlated. Further, examined evolutionary consequences agriculturally constructed niche Mesoamerica could be considered as a gene-culture coevolution model. For this purpose,...
Reaction of the chlorogermylene ArGeCl [Ar = 2,6-bis((diethylamino)methyl)phenyl] with lithium amides afforded aminogermylenes ArGeNR2 1 (1a, R SiMe3; 1b, iPr); 1a was structurally analyzed by X-ray diffraction. A protic reagent such as 2,4,6-trimethylphenol (Ar'OH) reacts leading to mesityloxygermylene ArGeOAr' 2. Subsequent hydrolysis tungsten complexes 1·W(CO)5 gave ArGeOH·W(CO)5, 3. From 1a, ArGeOSiMe3·W(CO)5 (4) also obtained. Compounds 3 and 4 are first stable hydroxy- siloxygermylene...
The archeological record indicates that the permanent settlement of Cyprus began with pioneering agriculturalists circa 11,000 years before present, (ca. y BP). Subsequent colonization events followed, some recognized regionally. Here, we assess Y-chromosome structure in context to regional populations and correlate it phases prehistoric colonization.Analysis haplotypes from 574 samples showed island-wide substructure was barely significant a spatial analysis molecular variance (SAMOVA)....
Summary Blood samples collected in four Amerindian French Guiana populations (Palikur, Emerillon, Wayampi and Kali'na) the early 1980s were screened for selected mtDNA Y‐chromosome length polymorphisms, sequenced hypervariable segment I (HVS‐I). In addition, two other (Apalaí Matsiguenga) examined same markers to establish genetic relationships area. Strong dissimilarities observed distribution of founding haplogroups, significant p‐values obtained from F ST distances. Interpopulation...
Six decades ago the DI*A allele of Diego blood group system was instrumental in proving Native American populations originated from Siberia. Since then, it has received scant attention. The present study undertaken to reappraise distribution 144 based on current knowledge. Using analysis variance tests, frequency studied according geographical, environmental, and cultural parameters. Frequencies were highest Amazonian populations. In contrast, undetectable subarctic, Fuegian, Panamanian,...
A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well its 5′and 3′flanking intronic segments (232 bp 220 bp, respectively) integrated with information available for same genetic region individuals different geographical origins. Nine mutations scored six flanking regions; four them are new American tribe-specific singletons. Exon3 nucleotide diversity is several...
Despite being the fourth largest island in Mediterranean basin, genetic variation of Corsica has not been explored as exhaustively Sardinia, which is situated only 11 km South. However, it likely that populations two islands shared, at least part, similar demographic histories. Moreover, relative small size may have caused isolation, which, turn, might be relevant under medical and translational perspectives. Here we analysed genome wide data 16 Corsicans, integrated with newly (33...
Background: Previous investigations of French Guiana Amerindians performed by this group included blood and protein genetic markers, mitochondrial DNA Y-chromosome investigations. Molecular autosomal data more extensive determinations were lacking.Subjects methods: The variability 15 autosome (ASTRs) 17 (YSTRs) microsatellite loci was studied in four (Emerillon, Palikur, Wayampi, Kali'na) one Brazilian (Apalai) Amerindian populations. A sixth group, the Peruvian Matsiguenga Maipurean...
Summary Background and Objectives Blood incompatibility arises from individual ethnic differences in red blood cell ( RBC ) antigen profiles. This underlines the importance of documenting variability various groups. Central Asia is an area with a long complex migratory history. The purpose this article to describe key frequencies Afghan groups Hindu‐Kush region Afghanistan as basis for improving transfusion practices that area. Materials Methods ABO , Rh Kell antigens were investigated five...
Blood group systems were the first phenotypic markers used in anthropology to decipher origin of populations, their migratory movements, and admixture. The recent emergence new technologies based on decoding nucleic acids from an individual’s entire genome has relegated them primary application, blood transfusion. Thus, despite finer mapping modern human relation Neanderthal Denisova little is known about red cell groups these archaic populations. Here we analyze available high-quality...
Abstract Twelve blood group and protein systems from a total of 819 individuals six tribal groups (Apalaí‐Wayana, Emerillon, Kaliña, Palikur Wayampi, Wayana) living in French Guiana Brazil were compared with each other integrated previous results 17 South Amerindian populations studied for the same genetic markers. Using correspondence analysis, map methodologies, maximum linkage cluster analysis developed UPGMA method, we attempted to establish position these tribes among American Indians....
Red cell polymorphisms can provide evidence of human migration and adaptation patterns. In Eurasia, the distribution Diego blood group system remains unaddressed. To shed light on dispersal Dia antigen, we performed analyses correlations between frequencies DI*01 allele, C2-M217 C2-M401 Y-chromosome haplotypes ascribed as being Mongolian-origin language affiliations, in 75 Eurasian populations including frequency data from HGDP-CEPH panel. We revealed that reaches its highest Mongolia,...
Abstract Three sets of genetic markers (blood group plus protein polymorphisms, mitochondrial DNA, and Y‐chromosome) were compared in four French Guiana one Brazilian Amerindian populations. Spearman's rank correlation coefficient between five gene diversity statistics historical or present‐day population sizes showed significant values, indicating loss due to bottlenecks. The three furnished distinct admixture estimates, the blood polymorphisms could have overestimated European contribution...