A5006200677- Forensic and Genetic Research
- Genetic diversity and population structure
- Indigenous Cultures and History
- Race, Genetics, and Society
- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Genomics and Phylogenetic Studies
- Metabolism and Genetic Disorders
- Archaeology and ancient environmental studies
- Argentine historical studies
- Mitochondrial Function and Pathology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Forensic Anthropology and Bioarchaeology Studies
- Molecular Biology Techniques and Applications
- Wildlife Ecology and Conservation
- Names, Identity, and Discrimination Research
- Mediterranean and Iberian flora and fauna
- Nutrition, Genetics, and Disease
- Sexual Differentiation and Disorders
- Indigenous Studies and Ecology
- Romani and Gypsy Studies
- Primate Behavior and Ecology
- Environmental and Ecological Studies
- Genetic factors in colorectal cancer
- Migration, Education, Indigenous Social Dynamics
Instituto Multidisciplinario de Biología Celular
2014-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2024
Universidad Nacional de La Plata
2018-2024
Comisión de Investigaciones Científicas
2009-2022
Centro Científico Tecnológico - La Plata
2011-2017
National University of Jujuy
2011
Centro Científico Tecnológico - San Juan
2009
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis complex traits through admixture mapping. However, no genome-wide characterization across has yet been attempted. Here, we report an analysis in thirteen Mestizo populations (i.e. regions mainly European Native settlement) from seven countries based on data 678 autosomal 29 X-chromosome microsatellites. We found extensive variation American ancestry (and generally low levels...
We sequenced genomes from a ∼7,000 year old early farmer Stuttgart in Germany, an ∼8,000 hunter-gatherer Luxembourg, and seven hunter-gatherers southern Sweden. analyzed these data together with other ancient 2,345 contemporary humans to show that the great majority of present-day Europeans derive at least three highly differentiated populations: West European Hunter-Gatherers (WHG), who contributed ancestry all but not Near Easterners; Ancient North Eurasians (ANE), were most closely...
We analyzed 391 samples from 12 Argentinian populations the Center-West, East and North-West regions with Illumina Human Exome Beadchip v1.0 (HumanExome-12v1-A). did Principal Components analysis to infer patterns of populational divergence migrations. identified proportions European, African Native American ancestry found a correlation between distance Buenos Aires proportion ancestry, where highest corresponds Northernmost populations, which is also furthest capital. Most European sources...
We analysed the frequency of six Y-specific polymorphisms in 105 Amerindian males from seven different populations, 42 Caucasian males, and a small number African, Chinese, Melanesian origin. The combination three studied produced four Y-haplogroups. haplogroup A (non-variant) was most frequent one. Eighty-five percent Amerindians showing have alphoid II (αhII) DYS19A markers, an association that is found only 10% Caucasians has not been detected Asiatics Africans. Haplogroups C (YAP+) D...
We have characterized the mtDNA in normal and breast cancer tissues from seven patients. Both types of tissue showed point mutation heteroplasmies extensive deletions mtDNA. The analysis these polymorphisms allowed us to infer composition cell that underwent malignant transformation.
Similarly to other populations across the Americas, Argentinean trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration admixture events in pre- post-colonial times. However, little is known about sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals Argentina. This was combined previously published region then compared...
Abstract We analyzed 21 paragroup Q* Y chromosomes from South American aboriginal and urban populations. Our aims were to evaluate the phylogenetic status, geographic distribution, genetic diversity in these groups of compare degree variation relation Q1a3a haplotypes. All our series five samples North presented derivate state for M346, that is present upstream M3, determined Q1a3* paragroup. found a restrictive distribution low frequency America. assumed this could be reflecting extreme...
Reduced representation sequencing methods such as genotyping-by-sequencing (GBS) enable low-cost measurement of genetic variation without the need for a reference genome assembly. These are widely used in mapping and population genetics studies, especially with non-model organisms. Variant calling error rates, however, higher GBS than standard sequencing, particular due to restriction site polymorphisms, few computational tools exist that specifically model correct these errors. We developed...
The settlement of the Americas has been focus incessant debate for more than 100 years, and open questions regarding timing spatial patterns colonization still remain today. Phylogenetic studies with complete human Y chromosome sequences are used as a highly informative tool to investigate history populations in given time frame. To study phylogenetic relationships Native American lineages infer Americas, we analyzed Q Haplogroup, which is Pan-American haplogroup represents practically all...
The isonymy structure of Buenos Aires was studied based on its surname frequency. Information 2,552,359 voters the 28 districts used to estimate Lasker's coefficient relationship by (Ri), diversity according Fisher's a, consanguinity resulting from random (F), and Nei's, Euclidean distances. These distances were correlated with geographic distances, which calculated assigning an arbitrary point each district measuring a map city. Ri × 105 F 104 averages located south Rivadavia Avenue higher...
Abstract The weight of characters is a crucial step in different population analyses. We propose new formula to facilitate this while establishing scale that follows the criteria probability change each character. This method described for drawing median‐joining networks, yet it could also be used other methods which required. Am J Phys Anthropol, 2010. © 2010 Wiley‐Liss, Inc.
Y-chromosomal haplogroups and the Y-SNPs defining them are relevant for exploration of male lineages, inference paternal ancestry, reconstruction migration pathways, to name a few. Currently, over 300,000 have been reported, 20 main haplogroups. However, ascertainment bias in investigations has led some being overlooked, which hinders representative depiction certain populations their events. For pattern analyses first settlers Americas, Native American founding lineage Q-M3 needs be further...