A5030814281- Forensic and Genetic Research
- Yersinia bacterium, plague, ectoparasites research
- Indigenous Studies and Ecology
- Genetic diversity and population structure
- Forensic Anthropology and Bioarchaeology Studies
- Blood groups and transfusion
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Genomics and Phylogenetic Studies
- Race, Genetics, and Society
- ATP Synthase and ATPases Research
- Rangeland Management and Livestock Ecology
- T-cell and B-cell Immunology
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- Pacific and Southeast Asian Studies
- Genetic and phenotypic traits in livestock
- Molecular Biology Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Wildlife Ecology and Conservation
- Immunodeficiency and Autoimmune Disorders
- Genetic Associations and Epidemiology
- Animal Diversity and Health Studies
- Xenotransplantation and immune response
- Soil and Environmental Studies
Institute of Molecular and Cell Biology
2015-2021
Siberian Branch of the Russian Academy of Sciences
1992-2021
Russian Academy of Sciences
1994-2016
Institute of Archaeology and Ethnography
2015
Altai State University
2015
Institute of Cytology and Genetics
1997-2012
Institute of Molecular Genetics
2012
Institute of Chemical Biology and Fundamental Medicine
2010-2011
Emory University
1996-2002
Wellcome Centre for Mitochondrial Research
2002
Human mtDNA shows striking regional variation, traditionally attributed to genetic drift. However, it is not easy account for the fact that only two lineages (M and N) left Africa colonize Eurasia A, C, D, G show a 5-fold enrichment from central Asia Siberia. As an alternative drift, natural selection might have enriched certain as people migrated north into colder climates. To test this hypothesis we analyzed 104 complete sequences all global regions lineages. African variation did...
Duplications and deletions in the human genome can lead to variation copy number for genes genomic loci among humans. Such variants reveal evolutionary patterns have implications health. Sudmant et al. examined copy-number across 236 individual genomes from 125 populations. Deletions were under more selection, whereas duplications showed population-specific structure. Interestingly, Oceanic populations retain large postulated originated an ancient Denisovan lineage. Science , this issue...
Humans inhabit a remarkably diverse range of environments, and adaptation through natural selection has likely played central role in the capacity to survive thrive extreme climates. Unlike numerous studies that used only population genetic data search for evidence selection, here we scan human genome signals by identifying SNPs with strongest correlations between allele frequencies climate across 61 worldwide populations. We find striking enrichment genic nonsynonymous relative non-genic...
Human populations use a variety of subsistence strategies to exploit an exceptionally broad range ecoregions and dietary components. These aspects human environments have changed dramatically during evolution, giving rise new selective pressures. To understand the genetic basis adaptations, we combine population genetics data with ecological information detect variants that increased in frequency response Our approach detects SNPs show concordant differences allele frequencies across respect...
In this study, we analyzed the mitochondrial DNA (mtDNA) variation in 202 individuals representing one Itel'men and three Koryak populations from different parts of Kamchatka peninsula. All mtDNAs were subjected to high resolution restriction (RFLP) analysis control region (CR) sequencing, resulting data combined with those available for other Siberian east Asian statistical phylogenetic analysis. Together, Koryaks found have belonging (A, C, D) four major haplotype groups (haplogroups)...
Summary In search of the ancestors Native American mitochondrial DNA (mtDNA) haplogroups, we analyzed mtDNA 531 individuals from nine indigenous populations in Siberia. All mtDNAs were subjected to high‐resolution RFLP analysis, sequencing control‐region hypervariable segment I (HVS‐I), and surveyed for additional polymorphic markers coding region. Furthermore, selected according haplogroup/subhaplogroup status completely sequenced. Phylogenetic analyses resulting data, combined with those...
A commonly held theory is that the first wave of migrants into New World was derivative from ethnic groups then inhibiting eastern Siberia. However, these lack a mtDNA haplogroup (B) well represented in Amerindian tribes. Also, time depth other three haplogroups found Amerindians (A, C, and D) appears to be greater than Siberian groups. In this communication we demonstrate human T-cell lymphotrophic virus type II, present 11 38 tribes thus far examined, not any 10 Siberia have studied. has...
Abstract To fill remaining gaps in mitochondrial DNA diversity the least surveyed eastern and western flanks of Siberia, 391 mtDNA samples (144 Tubalar from Altai, 87 Even northeastern 160 Ulchi Russian Far East) were characterized via high‐resolution restriction fragment length polymorphism/single nucleotide polymorphisms analysis. The subhaplogroup structure was extended through complete sequencing 67 selected these other related native Siberians. Specifically, we have focused on...
Summary Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes isotypes the respective sub‐classes. These individuals homozygous sub‐class deleted Gm‐Am haplotypes, as shown allotype studies in two families ( Gm‐;…;g;A2ml/Gm‐;n;b;A2ml Gm‐;n;b;A2ml/Gm‐;…;b;A2ml ) a population study New Guineans Gm fa;‐;b;A2m2 ). The IgGl deficiency showed elevation IgG2, IgG4 particular IgG3. Gene deletion can result from unequal crossing over which renders complementary...