A5035336923- Genetic Associations and Epidemiology
- Forensic and Genetic Research
- Genetic diversity and population structure
- Genetics and Neurodevelopmental Disorders
- Digestive system and related health
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Nutrition, Genetics, and Disease
- Race, Genetics, and Society
- Human Health and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Forensic Anthropology and Bioarchaeology Studies
- Epigenetics and DNA Methylation
- Cognitive Abilities and Testing
- Agriculture and Biological Studies
- Indigenous Studies and Ecology
- Genetics and Physical Performance
- Yersinia bacterium, plague, ectoparasites research
- Genetic Neurodegenerative Diseases
- Congenital heart defects research
- Birth, Development, and Health
- Schizophrenia research and treatment
- Health, Environment, Cognitive Aging
Dagestan State University
2016-2019
Vavilov Institute of General Genetics
2006-2017
University Medical Center Utrecht
2017
University of Washington
2017
Russian Academy of Sciences
2002-2015
Dagestan Scientific Center of the Russian Academy of Sciences
2006
Institute of History
2003-2006
We report an analysis of more than 240,000 loci genotyped using the Affymetrix SNP microarray in 554 individuals from 27 worldwide populations Africa, Asia, and Europe. To provide a extensive complete sampling human genetic variation, we have included caste tribal samples two states South India, Daghestanis eastern Europe, Iban Malaysia. Consistent with observations made by Charles Darwin, our results highlight shared variation among demonstrate that much is geographically continuous. At...
Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into history our species. Several landmark papers described genomes ancient humans across West Eurasia, demonstrating presence large-scale, dynamic population movements over last 10,000 such that ancestry present-day populations is likely to be a mixture several groups [1-7]. While these efforts are bringing details Eurasian prehistory increasing focus,...
Inflammatory bowel disease 5 (IBD5) is a 250 kb haplotype on chromosome that associated with an increased risk of Crohn's in Europeans. The OCTN1 gene centrally located IBD5 and encodes transporter the antioxidant ergothioneine (ET). 503F variant strongly gain-of-function mutation increases absorption ET. Although has been implicated as potentially responsible for susceptibility at IBD5, there little evidence beyond statistical association to support its role causation. We hypothesize recent...
We describe a unique six-generation, highly consanguineous family originating from an isolated mountainous village in the Russian province of Daghestan. Three separate clinical phenotypes progressive muscular dystrophy were identified this large family. Seven patients developed classical limb-girdle variant (LGMD), with disease onset at 15-30 years and loss ambulation within 25-year course. The second group included three slowly distal myopathy first manifested late teens confined to tibial...
We have surveyed 15 high-altitude adaptation candidate genes for signals of positive selection in North Caucasian highlanders using targeted re-sequencing. A total 49 unrelated Daghestani from three ethnic groups (Avars, Kubachians, and Laks) living ancient villages located at around 2,000 m above sea level were chosen as the study population. (Adygei level, N = 20) CEU (CEPH Utah residents with ancestry northern western Europe; used controls. Candidate compared 20 putatively neutral control...
We describe aspects of genetic diversity in several ethnic populations the Caucasus Mountains Daghestan using mitochondrial DNA sequences and a sample 100 polymorphic Alu insertion loci. The (mtDNA) are like those Europe. Principal coordinates nearest neighbor statistics show that there is little detectable structure distances among computed from mtDNA. frequencies suggest they have undergone more drift than most other groups since dispersal modern humans. Genetic differences these not...
Abstract Background Near the junction of three major continents, Caucasus region has been an important thoroughfare for human migration. While Mountains have diverted traffic to few lowland regions that provide a gateway from north south between Caspian and Black Seas, highland populations isolated by their remote geographic location practice patrilocal endogamy. We investigate how these cultural historical differences affected patterns genetic diversity. test 1) whether endogamy generated...
Genetic isolates, which provide outstanding opportunities for identification of susceptibility genes complex diseases, can be classified as primary (having an ancient demographic history in a stable environment) or secondary younger history) Neel [1992: Minority populations: Genetics, demography, and health, pp. 1-13]. Daghestan contains 26 out 50 indigenous Caucasus ethnicities that have been existence hundreds generations the same highland region. The ethnic groups are subdivided into...
Abstract Autosomal short‐tandem repeats (STRs) were typed in ethnic populations of Kubachians, Dargins, Avars, Lezgins, Kumiks, and Nogais the Caucasus (Daghestan, Russia) at University Utah. Daghestan demonstrated differences STR allele frequency distributions, but these much lower among groups compared to worldwide groups. The observed genetic diversity was low while F ST values high, both which provided supporting evidence for small population sizes high levels isolation An analysis...
Abstract Objectives: Tat language is classified in an Iranian subbranch of the Indo‐European family. It spoken Caucasus and West Caspian region by populations with heterogeneous cultural traditions religion whose ancestry unknown. The aim this study to get a first insight about genetic history peculiar linguistic group. Methods: We investigated uniparental gene pools, defined NRY mtDNA high‐resolution markers, two Tati‐speaking communities from Dagestan: Mountain Jews or Juhur, who speak...