A5060781990- Acute Lymphoblastic Leukemia research
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Iron Metabolism and Disorders
- RNA modifications and cancer
- Childhood Cancer Survivors' Quality of Life
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Cholesterol and Lipid Metabolism
- Ultrasound and Hyperthermia Applications
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Ginger and Zingiberaceae research
- Metabolism and Genetic Disorders
- DNA Repair Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Nuclear Receptors and Signaling
University of Isfahan
2016-2025
Isfahan University of Technology
2023
Institute of Molecular and Cell Biology
2013
William Harvey Research Institute
2010
King's College London
2010
St George Hospital
2006-2010
UNSW Sydney
2006-2010
University of Birmingham
2010
High Institute for Education and Research in Transfusion Medicine
2007
Tarbiat Modares University
2000
Multidrug resistance (MDR) is considered as the major obstacle for treating pediatric acute lymphoblastic leukemia (ALL). MicroRNAs (miRNAs) are small non coding RNAs which may potentially regulate response to chemotherapy. In this study, total RNA was isolated from bone marrow samples of 46 children with de novo ALL and 16 controls. Quantitative reverse transcriptase polymerase chain reaction used investigate expression profile predicted miRNAs; miR-326 miR-200c, their targets ABCA2, ABCA3...
Alzheimer’s disease (AD) is a neurodegenerative with cognitive impairment. Oxidative stress in neurons considered as reason for development of AD. Antioxidant agents such quercetin slow down AD progression, but the usage this flavonoid has limitations because its low bioavailability. We hypothesized that quercetin-conjugated superparamagnetic iron oxide nanoparticles (QT-SPIONs) have better neuroprotective effect on than free and regulates antioxidant, apoptotic, APP gene, miRNA-101. In...
Abstract Acute lymphoblastic leukemia (ALL) is a cancer with high incidence rate in pediatrics and drug resistance major clinical concern for ALL treatment. The current study was designed to evaluate the role of exosomal miR-326 diagnosis treatment children B-ALL. Exosomes were isolated from plasma samples 30 patients B-ALL cell lines followed by characterization, using nanoparticle tracking analysis, immunoblotting assay electron microscopy. qPCR showed significantly increased levels...
Multidrug resistance (MDR) is an important cause of treatment failure in acute lymphoblastic leukemia (ALL). The ABC family membrane transporters proposed, albeit with controversy, to be involved this process. present study aims investigate the mRNA expression profile several genes family, including ABCA2, ABCA3, ABCB1/MDR1, MRP1/ABCC1, MRP3/ABCC3, ABCG2/BCRP, and intracellular transporter MVP/LRP, childhood ALL, evaluate their association response therapy. Some research are being studied...
MiR-326 downregulation is strongly associated with multidrug resistance (MDR) and has been identified as an adverse prognostic biomarker for pediatric acute lymphoblastic leukemia (pALL). The choice to study miR-326 a tumor suppressor in cancer biology, particularly its regulation of apoptosis, drug resistance, stemness, stems from strong association MDR potential therapeutic target pALL. current aimed investigate, the first time, molecular mechanisms underlying role ALL, using Gene Ontology...
Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children worldwide. In present investigation, circulating RNAs (circRNAs) HOTAIR, NEAT1, H19, PCAT1, and SNHG1 were selected as potential biomarkers for childhood ALL (pALL) based on their predicted interactions with miR-326, a recognized tumor suppressor implicated pALL, along comprehensive silico analyses. Subsequently, expression levels of circRNAs examined 50 pALL samples 20 healthy controls using RT-qPCR. Notably, HOTAIR...
Genotyping of single-nucleotide polymorphisms (SNPs) has been applied in various genetic contexts. Tetra-primer amplification refractory mutation system (ARMS) polymerase chain reaction (PCR) is reported as a prominent assay for SNP genotyping. However, there were published data that may question the reliability this method on some occasions, addition to laborious and time-consuming procedure optimization step. In current study, new genotyping named modified tetra-primer ARMS (MTPA) PCR was...
Acute lymphoblastic leukemia (ALL) is the major neoplasia type among children. Despite tremendous success of current treatment strategies, drug resistance still remains a cause chemotherapy failure and relapse in pediatric patients. Overwhelming evidence illustrates that microRNAs (miRNAs) act as post-transcriptional regulators drug-resistance-related genes. The study was aimed at how dysregulated miRNA-mRNA-signaling pathway interaction networks mediate to four commonly used agents ALL,...
Purpose: The aim of this work was to study the correlation between expressions ABCA2 and ABCA3 genes at mRNA protein levels in children with acute lymphoblastic leukemia (ALL) effects association on multidrug resistance (MDR). Materials methods: Sixty-nine de novo ALL 25 controls were enrolled study. Mononuclear cells isolated from bone marrow. measured by real-time polymerase chain reaction (PCR). Samples high assessed for respective Western blotting. Following first year treatment,...
Background: Multidrug resistance is one of the major causes treatment failure in pediatric acute lymphoblastic leukemia (ALL), and SORCIN an intracellular calcium modulator protein. The current study was designed to investigate vitro vivo relationships between expression levels SORCIN: tumor cell lines children with ALL; its possible correlation MDR1/P-glycoprotein (P-gp), a multidrug resistance-related gene; response therapy. Materials Methods: Childhood T-lymphoblastic (CCRF-CEM) resistant...
We recently showed that quercetin-conjugated iron oxide nanoparticles (QNPs) promoted the bioavailability of quercetin (Qu) in brain rats and improved learning memory diabetic rats. In this study, we characterized modifications antitoxic effects Qu after conjugation.We conjugated to dextran-coated (DNPs) DNPs QNPs using FTIR, XRD, DLS, Fe-SEM, EDX analyzes. The antiradical properties Qu, DNPs, were compared by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity assay. Catalase-like...
Abstract Altered metabolism of fatty acid synthesis is considered a hallmark characteristic several malignancies, including acute lymphoblastic leukemia (ALL). To evaluate the impact synthase (FASN) on drug resistant ALL, bone marrow samples were collected from 65 pediatric ALLs, 40 de novo and 25 relapsed patients. 22 non-cancer individuals chosen as controls. Quantitative RT-PCR showed increased expression levels FASN in patients compared with therapy responders. Single combined treatment...