A5091325387- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Intraperitoneal and Appendiceal Malignancies
- Acute Myeloid Leukemia Research
- Drug Transport and Resistance Mechanisms
- Hedgehog Signaling Pathway Studies
- Total Knee Arthroplasty Outcomes
- Characterization and Applications of Magnetic Nanoparticles
- Nanoparticles: synthesis and applications
- Neuroscience and Neuropharmacology Research
- Cancer Research and Treatments
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Knee injuries and reconstruction techniques
- Bone Tissue Engineering Materials
- Protease and Inhibitor Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
Jena University Hospital
2020-2023
Friedrich Schiller University Jena
2020-2023
University of Isfahan
2014-2016
Magnetic nanoparticles (MNPs) have shown promising features to be utilized in combinatorial magnetic hyperthermia and chemotherapy. Here, we assessed if a thermo-chemotherapeutic approach consisting of the intratumoral application functionalized chitosan-coated MNPs (CS-MNPs) with 5-fluorouracil (5FU) prospectively improves treatment colorectal cancer. With utilization human cancer (HT29) heterotopic tumor model mice, showed that is more efficient inactivating colon than either treatments...
Background: Multidrug resistance is one of the major causes treatment failure in pediatric acute lymphoblastic leukemia (ALL), and SORCIN an intracellular calcium modulator protein. The current study was designed to investigate vitro vivo relationships between expression levels SORCIN: tumor cell lines children with ALL; its possible correlation MDR1/P-glycoprotein (P-gp), a multidrug resistance-related gene; response therapy. Materials Methods: Childhood T-lymphoblastic (CCRF-CEM) resistant...
In this study we looked for the main protein pathway regulators which were responsible therapeutic impact on colon cancers when combining magnetic hyperthermia with chemotherapeutic agent 5-fluorouracil (5FU). To end, chitosan-coated nanoparticles (MNP) functionalized 5FU intratumorally injected into subcutaneous human cancer xenografts (HT-29) in mice and exposed to an alternating field. A decreased tumor growth was found particularly combined thermo-chemotherapy vs. corresponding...
Magnetic nanoparticles (MNPs) are prone to exhibit physicochemical changes caused by their interaction with biological solutions. However, such interactions have been less considered in cancer therapy studies. The behavior of four iron oxide MNP formulations different surface coatings, namely, chitosan (CS), polyvinyl alcohol (PVA), carboxymethyldextran (CMX), and polydimethylamine (PEA), was investigated, after exposure cell culture media (DMEM/F12 MEM, among others) six lines (HT29,...
BAALC is a novel molecular marker in leukemia that highly expressed patients with acute leukemia. Increased expression levels of are known as poor prognostic factors adult myeloid and lymphoid The purpose the present study was to evaluate significance gene pediatric lymphoblastic (ALL) its association MDR1. Using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), mRNA MRD1 were measured bone marrow samples 28 new diagnosed childhood ALL 13 children without cancer....
The purpose of this study was to evaluate the treatment potential a human-derived demineralized scaffold, Spongioflex ® (SPX), in partial meniscal lesions by employing vitro models. In first step, differentiation human cells (MCs) investigated. next ability SPX accommodate and support adherence and/or growth MCs while maintaining their fibroblastic/chondrocytic properties studied. Control scaffolds, including bovine collagen meniscus implant (CMI) allograft (M-Allo), were used for comparison...