A5045958617- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer, Lipids, and Metabolism
- Nuclear Receptors and Signaling
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Adenosine and Purinergic Signaling
- Exercise and Physiological Responses
University of Isfahan
2016-2025
Royan Institute
2014-2024
Academic Center for Education, Culture and Research
2014-2024
Islamic Azad University Rasht Branch
2021-2023
Islamic Azad University of Shahrekord
2020-2023
Isfahan University of Technology
2020-2022
Isfahan University of Medical Sciences
2014-2018
Institute of Molecular and Cell Biology
2013
Kyushu University
1998-2010
Japan Science and Technology Agency
2000-2010
At least 11 complementation groups (CGs) have been identified for the peroxisome biogenesis disorders (PBDs) such as Zellweger syndrome, which seven pathogenic genes elucidated. We isolated a human PEX19 cDNA ( HsPEX19 ) by functional of deficiency mutant Chinese hamster ovary cell line, ZP119, defective in import both matrix and membrane proteins. This encodes hydrophilic protein (Pex19p) comprising 299 amino acids, with prenylation motif, CAAX box, at C terminus. Farnesylated Pex19p is...
In mammals, two isoforms of the peroxisome targeting signal (PTS) type 1 receptor Pex5p, <i>i.e.</i> Pex5pS and Pex5pL with an internal 37-amino acid insertion, have previously been identified. Expression either Pex5p complements impaired PTS1 import in Chinese hamster ovary <i>pex5</i> mutants, but only can rescue PTS2 defect noted a subgroup mutants such as ZP105. this work, we found that directly interacts Pex7p, carrying its cargo protein cytosol. Pex5pL, not Pex5pS, mediated binding to...
Rat cDNA encoding a 376-amino acid peroxin was isolated by functional complementation of peroxisome-deficient Chinese hamster ovary cell mutant, ZP110, group 14 (CG14). The primary sequence showed 28 and 24% amino identity with the yeast Pex14p from Hansenula polymorpha andSaccharomyces cerevisiae, respectively; therefore, we termed this rat PEX14 (RnPEX14). Human 96 94% to Pex14p, except that both comprised 377 acids. characterized as an integral membrane protein peroxisomes, exposing its...
To date, mutations in two genes, SPATA16 and DPY19L2, have been identified as responsible for a severe teratozoospermia, namely globozoospermia. The initial descriptions of the DPY19L2 deletion lead to very different rate occurrence this mutation among globospermic patients. In order better estimate contribution globozoospermia, we screened larger cohort including 64 globozoospermic Twenty new patients were homozygous deletion, 7 compound heterozygous both point mutation. We also four...
Background One of the main issues in pathogenesis MS is Th17/Treg imbalance. There are growing interests nominating miRNAs involved Th17 cell differentiation, suggesting them as new therapeutic agents that may reduce progression different autoimmune diseases specially MS. Objectives We assessed transcript levels miR-141 and miR-200a patients, during relapsing remitting phases. also investigated possible role miR-141, inducing differentiation to cells. Materials Methods Forty RR-MS patient...
The investigation of agents promoting recovery nerve regeneration following neurodegenerative diseases has been the most important issue in neuroscience. Nerve growth factor (NGF) and quercetin as potential flavonoids could possibly have therapeutic applications field degenerative such Parkinson Alzheimer.The MTT assay was done at 24, 48, 72 hours to examine cytotoxicity superparamagnetic iron oxide nanoparticles (SPIONs) quercetin. We combined NGF with different concentrations SPIONs novel...
Kefiran is a useful polysaccharide made of branched glucogalactose which produced by microorganisms. Here the anti-MCF-7 breast cancer cells activity kefiran and cytokine productions (IL-6) peripheral blood mononuclear (PBMC) treated was studied. Also, effect using as cost-effective scaffold in neural stem cell culture (PC12 culture) investigated.Kefiran from raw milk with 0.5% fat 10 g kefir grains. After incubation for 48 hrs at room temperature, solvent collected (crude kefiran). These...
Rat cDNA encoding a 372-amino-acid peroxin was isolated, primarily by functional complementation screening, using peroxisome-deficient Chinese hamster ovary cell mutant, ZPG208, of group 17. The deduced primary sequence showed ∼25% amino acid identity with the yeast Pex3p, thereby we termed this ratPEX3 (RnPEX3). Human and Pex3p 96 94% to rat had 373 acids. characterized as an integral membrane protein peroxisomes, exposing its N- C-terminal parts cytosol. A homozygous, inactivating missense...
BACKGROUNDFailed fertilization post-ICSI has been mainly attributed to the sperm's inability induce oocyte activation. Phospholipase C zeta (PLCζ) is considered be one of factors for induction The aim this study was quantitatively assess expression PLCζ in globozoospermic men or those with previously low failed comparison fertile high potential. In addition, relationship between and that other sperm markers evaluated.