A5035890545- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Acute Myeloid Leukemia Research
- interferon and immune responses
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Urologic and reproductive health conditions
- Cancer therapeutics and mechanisms
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Protein Degradation and Inhibitors
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Ovarian function and disorders
- SARS-CoV-2 and COVID-19 Research
- Anatomy and Medical Technology
- Renal and Vascular Pathologies
- RNA Research and Splicing
- Kidney Stones and Urolithiasis Treatments
- Cancer Mechanisms and Therapy
- Prenatal Screening and Diagnostics
- Extracellular vesicles in disease
- COVID-19 Clinical Research Studies
University of Isfahan
2019-2024
Royan Institute
2012-2019
Academic Center for Education, Culture and Research
2012-2019
To date, mutations in two genes, SPATA16 and DPY19L2, have been identified as responsible for a severe teratozoospermia, namely globozoospermia. The initial descriptions of the DPY19L2 deletion lead to very different rate occurrence this mutation among globospermic patients. In order better estimate contribution globozoospermia, we screened larger cohort including 64 globozoospermic Twenty new patients were homozygous deletion, 7 compound heterozygous both point mutation. We also four...
Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of vitro (IVF) oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety processes, organelles structures are involved acrosome biogenesis including, trans-golgi network (TGN), acroplaxome cellular trafficking. This review aims explain roles related signals molecules this process also describe how their form mutation, deletion knockout model may lead...
Abstract MiR-34b-5p has been reported as a non-invasive diagnostic biomarker for infertility. However, no gene targets regulating the mechanism of cation this miRNA are known. In study, using set enrichment analysis Inositol 1,4,5-Trisphosphate Receptor Type 1 ( ITPR1) was identified sole target hsa-miR-34b-5p, and found significantly overexpressed in non-obstructive azoospermia (NOA) patients. This finding confirmed by qRT-PCR on fresh testicular tissues from NOA Then, pathway well value...
Globozoospermia is a rare syndrome with an incidence of less than 0.1% among infertile men. Researchers have recently identified large deletion, about 200 kbp, encompassing the whole length DPY19L2 or mutations in SPATA16 and PICK1 genes associated globozoospermia. The aim this study was to analyze gene deletion using polymerase chain reaction technique for exons 1, 48, 11 22 as well break point (BP) "a" globozoospermic men.In experimental study, genome samples were collected from 27 men...
Abstract Background Significant miss‐expressed gene indicators contributing to cisplatin resistance in ovarian cancer have not been completely understood. It seems that several regulatory genes and signaling pathways are associated with the emergence of chemo‐resistant phenotype. Aims Here, a meta‐analysis approach was adopted assess deregulated involved relapse after first line chemotherapy (cisplatin). Methods Results To do so, six libraries were gathered from GEO repository. Batch effect...
Abstract The pathways and robust deregulated gene signatures involved in AML chemo-resistance are not fully understood. Multiple subgroups of AMLs which under treatment various regimens seem to have similar regulatory gene(s) or pathway(s) related their phenotype. In this study using set enrichment approach, genes associated with relapse after chemotherapy were investigated samples. Five libraries compiled from GEO ArrayExpress repositories used identify significantly differentially...