A5058736974- MicroRNA in disease regulation
- RNA regulation and disease
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- interferon and immune responses
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Psoriasis: Treatment and Pathogenesis
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- IL-33, ST2, and ILC Pathways
- Electrospun Nanofibers in Biomedical Applications
- Galectins and Cancer Biology
- Sirtuins and Resveratrol in Medicine
- T-cell and B-cell Immunology
- Otitis Media and Relapsing Polychondritis
- Chronic Lymphocytic Leukemia Research
Royan Institute
2018-2023
University of Isfahan
2017-2023
Academic Center for Education, Culture and Research
2018-2023
Abstract Parkinson's disease (PD) is a frequent progressive neurodegenerative disorder. Impaired mitochondrial function major feature of sporadic PD. Some susceptibility or causative genes detected in PD are strongly associated with dysfunction including PGC1α , TFAM and GSK3β . microRNAs (miRNAs) non‐coding RNAs whose altered levels proven disparate models human brains. Therefore, the aim this study was to detect modulations miRs upstream association onset progress. In study, total 33...
Abstract Background Parkinson's disease (PD) is ranked as the second most common neurodegenerative disorder caused by loss of dopaminergic neurons in substantia nigra. Micro(mi)RNAs are a class small noncoding RNAs that regulate gene expression and aberrant them closely correlated with many conditions including PD. Silent information regulator 1 ( SIRT1 ) known deacetylase B‐cell lymphoma‐2 BCL2 an antiapoptotic factor play vital roles neural protection survival. Methods Differentiated PC12...
Abstract PGC‐1α/FNDC5/BDNF has found to be a critical pathway in neurodegeneration. MicroRNAs (miR(NA)s) are non‐coding regulatory RNAs whose dysregulation been observed multiple neurological disorders, and miRNA‐mediated gene deregulation plays decisive role PD. Here, candidate miRNA was chosen based on the literature survey silico studies. Chronic acute models of PD were created using MPP+‐treated SH‐SY5Y cells. Twenty patients 20 healthy volunteers recruited. RT‐qPCR performed assess...
Multiple sclerosis (MS) is a chronic disorder involving both inflammatory and neurodegenerative responses. Long non-coding RNAs (lncRNAs) have been had an emerging role as the biomarkers of different disorders, including autoimmune diseases. Previous studies shown that NR_003531.3 (MEG3a), AC000061.1_201, AC007182.6 play in pathogenesis human However, potential significance these lncRNAs, diagnostic MS, has not studied yet. We aimed to quantitatively evaluate expression levels NR_003531.3,...
KEYWORDS: 3' untranslated regionBioinformaticsBreast neoplasmsKinesin family member 14microRNAsingle nucleotide polymorphism
Overexpression of miR-141 and miR-200a is known to be associated with the differentiation T helper 17 (Th17) cells, which are key players in pathophysiology autoimmune disorders. However, function governing mechanism these two microRNAs (miRNAs) Th17 cell skewing poorly defined.The aim present study was identify common upstream transcription factors downstream target genes obtain a better insight into possible dysregulated molecular regulatory networks driving miR-141/miR-200a-mediated...
Abstract Background Th17 cells are a newly discovered subset of CD4 + T known as key participants in various immune responses and inflammatory conditions including autoimmune diseases. Mi(cro)RNAs family non‐coding RNAs that regulate numerous critical functions. Immuno‐miRNAs modulate cell biological processes cells, such differentiation function cells. The aim the present study is to investigate expression miR‐9‐5p, miR‐193b‐3p, autoimmunity‐related genes during human differentiation....
Abstract Background: Among T helper (Th) lineages differentiated from naïve CD4 + cells, interleukin (IL)-17-producing Th17 cells are highly correlated with the pathogenesis of autoimmune disorders. Although a series microRNAs (miRs) that modulate autoimmunity progress have been reported, further studies on particularly involved in lineage commitment still warranted. Results: In this study, to clarify involvement miR-141-3p and miR-200a-3p cell differentiation, as well explore their...
The cover image is based on the Original Article Upregulation of miR-9 and miR-193b over human Th17 cell differentiation by Fahimeh Shirani et al., https://doi.org/10.1002/mgg3.1538