Alessandro Esposito
A5054911905- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 and healthcare impacts
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Prostate Cancer Treatment and Research
- Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Trauma and Emergency Care Studies
University of Verona
2014-2024
General Motors (India)
2024
European Institute of Oncology
2012-2024
National Research Council
2024
Azienda Ospedaliera Universitaria Integrata Verona
2023-2024
Yahoo (United Kingdom)
2024
Barro Colorado Island
2024
Jisc
2023
Pancreas Centre (Canada)
2017-2023
Cancer Center Amsterdam
2023
This multicenter study sought to prospectively evaluate a drain management protocol for pancreatoduodenectomy (PD).Recent evidence suggests value both selective placement and early removal PD. Both strategies have been associated with reduced rates of clinically relevant pancreatic fistula (CR-POPF)-the most common morbid complication after PD.The was applied 260 consecutive PDs performed at two institutions over 17 months. Risk ISGPF CR-POPF determined intraoperatively using the Fistula...
The oncological safety of minimally invasive surgery has been questioned for several abdominal cancers. Concerns also exist regarding the use distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer as randomised trials are lacking.In this international non-inferiority trial, we recruited adults from 35 centres 12 countries. Patients were randomly assigned to either MIDP (laparoscopic or robotic) open (ODP). Both and pathologists blinded approach. Primary endpoint was...
Objective: To develop and update evidence- consensus-based guidelines on laparoscopic robotic pancreatic surgery. Summary Background Data: Minimally invasive surgery (MIPS), including surgery, is complex technically demanding. Minimizing the risk for patients requires stringent, evidence-based guidelines. Since International Miami Guidelines MIPS in 2019, new developments key publications have been reported, necessitating an update. Methods: Evidence-based 22 topics 8 domains were proposed:...
<h3>Importance</h3> Chemotherapy is the recommended induction strategy in borderline resectable and locally advanced pancreatic ductal adenocarcinoma. However, associated results on an intention-to-treat basis are poorly understood. <h3>Objective</h3> To investigate pragmatically treatment compliance, conversion to surgery, survival outcomes of patients with adenocarcinoma undergoing primary chemotherapy. <h3>Design, Setting, Participants</h3> This prospective study took place a national...
The operative scenarios with the highest postoperative pancreatic fistula (POPF) risk represent situations in which prevention and mitigation strategies have strongest potential to affect surgical outcomes after pancreaticoduodenectomy. Evidence from studies providing stratification is lacking.To investigate whether pancreaticojejunostomy (PJ) or pancreaticogastrostomy (PG), both externalized transanastomotic stent, best reconstruction method for patients at high of POPF...
Different in silico models have been developed and implemented for the evaluation of mammalian acute toxicity, exploring oral toxicity data expressed as median lethal dose (LD50). We compared five software programs (TOPKAT, ACD/ToxSuite, TerraQSAR, ADMET Predictor T.E.S.T.) using a dataset 7417 chemicals. tested models' performance quantitative results and, classification, threshold defined within Classifying, Labelling Packaging (CLP) regulation. ACD gave best with r2 0.79 0.66 accuracy....
Objective: The aim of the present study was to evaluate clinical implications 2016 International Study Group for Pancreatic Surgery (ISGPS) definition and classification postoperative pancreatic fistula (POPF) using a single high-volume institutional cohort patients undergone surgery. Background: ISGPS grading system POPF has been recently updated. Although rationale changes supported by previous studies, effect new scheme on surgical series not established. Methods: A total 775 surgery in...
The role of minimally invasive distal pancreatectomy is still unclear, and whether robotic (RDP) offers benefits over laparoscopic (LDP) unknown because large multicentre studies are lacking. This study compared perioperative outcomes between RDP LDP.A international propensity score-matched included patients who underwent or LDP for any indication in 21 European centres from six countries that performed at least 15 pancreatectomies annually (January 2011 to June 2019). Propensity score...
Objective: The aim of the present study was to critically reappraise experience at our high-volume institution obtain new insights for future directions. Summary Background Data: indications, surgical techniques, and perioperative management pancreatoduodenectomy (PD) have profoundly evolved over last 20 years. Methods: All consecutive PDs performed during years Verona Pancreas Institute were divided into four 5-year timeframes retrospectively analyzed in terms intraoperative features,...
To develop 2 distinct preoperative and intraoperative risk scores to predict postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP) improve preventive mitigation strategies, respectively.POPF remains the most common complication DP. Despite several known factors, an adequate model has not been developed yet.Two prediction were designed using data of patients undergoing DP in Italian centers (2014-2016) utilizing multivariable logistic regression. The score (calculated...
Robot-assisted distal pancreatectomy (RDP) is increasingly used as an alternative to laparoscopic (LDP) in patients with resectable pancreatic cancer but comparative multicenter studies confirming the safety and efficacy of RDP are lacking.An international, multicenter, retrospective, cohort study, including consecutive undergoing LDP for 33 experienced centers from 11 countries (2010-2019). The primary outcome was R0-resection. Secondary outcomes included lymph node yield, major...
Objective: To investigate whether revision of pancreatic neck margin based on intraoperative frozen section analysis has oncologic value in post-neoadjuvant pancreatoduodenectomy (PD) for ductal adenocarcinoma (PDAC). Summary Background Data: The role been controversial, with little information specific to PD. Methods: Patients who underwent PD (2013-2019) conventional PDAC at three academic institutions were included. Overall survival (OS) and recurrence-free (RFS) compared across groups:...
Objective: The objective of the present analysis is 2-fold: first, to define evolution time trends on surgical approach pancreatic neuroendocrine neoplasms (Pan-NENs); second, perform a complete predictors oncologic outcome. Background: Reflecting their rarity and heterogeneity, Pan-NENs represent clinical dilemma. In particular, there scarcity data regarding long-term follow-up after resection. Methods: From Institutional Pan-NEN database, 587 resected cases from 1990 2015 were extracted....
Abstract Background Recently, the first randomized trials comparing minimally invasive distal pancreatectomy (MIDP) with open (ODP) for non-malignant and malignant disease showed a 2-day reduction in time to functional recovery after MIDP. However, pancreatic ductal adenocarcinoma (PDAC), concerns have been raised regarding oncologic safety (i.e., radical resection, lymph node retrieval, survival) of MIDP, as compared ODP. Therefore, controlled trial MIDP ODP PDAC oncological is warranted....