A5103013095- Environmental and Agricultural Sciences
- Advanced Algorithms and Applications
- RNA modifications and cancer
- Hydrology and Watershed Management Studies
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- RNA and protein synthesis mechanisms
- Environmental Changes in China
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Rangeland Management and Livestock Ecology
- Blind Source Separation Techniques
- Plant Water Relations and Carbon Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Industrial Technology and Control Systems
- Brain Tumor Detection and Classification
- Rangeland and Wildlife Management
- Soil Carbon and Nitrogen Dynamics
- Membrane Separation Technologies
- Advanced Measurement and Metrology Techniques
- Evaluation and Optimization Models
- Advanced Surface Polishing Techniques
- Environmental Quality and Pollution
- Toxoplasma gondii Research Studies
- Cancer-related molecular mechanisms research
Baylor College of Medicine
2022-2025
Fujian Medical University
2025
Union Hospital
2025
Northeastern University
2022-2024
Jilin University
2009-2021
University of Houston
2015-2019
Toronto Metropolitan University
2019
China Agricultural University
2011-2014
Jiangxi Agricultural University
2008-2012
Beijing Normal University
2012
Pancreatic adenocarcinoma (PAAD) has a very poor prognosis, and there are few treatments for PAAD. Therefore, it is important to find some biomarkers the diagnosis treatment of Although members Armadillo repeat containing proteins (ARMCs) have been implicated in development certain cancers, their relationship with PAAD remains unknown. In this study, we aimed explore expression prognostic value ARMCs We used The Cancer Genome Atlas (TCGA) database survival analysis. Then, Gene Expression...
Abstract Endometriosis is a common and debilitating disease, affecting ∼170 million women worldwide. Affected patients have limited therapeutic options such as hormonal suppression or surgical excision of the lesions, though therapies are often not completely curative. Targeting receptor tyrosine kinases (RTKs) could provide nonhormonal treatment option for endometriosis. We determined that 2 RTKs, macrophage-colony stimulating factor 1 (CSF1R) mast/stem cell growth KIT (KIT), overexpressed...
Abstract N6-methyladenosine (m 6 A), one of the most prevalent mRNA modifications in eukaryotes, plays a critical role modulating both biological and pathological processes. However, it is unknown whether mutant p53 neomorphic oncogenic functions exploit dysregulation m A epitranscriptomic networks. Here, we investigate Li-Fraumeni syndrome (LFS)-associated neoplastic transformation driven by iPSC-derived astrocytes, cell-of-origin gliomas. We find that but not wild-type (WT) physically...
Abstract Background The importance of phosphorylation in sperm during spermatogenesis has not been pursued extensively. Testis‐specific serine kinase 3 ( Tssk3 ) is a conserved gene, but TSSK3 functions and substrates are known. Objective goals our studies were to understand the mechanism action TSSK3. Materials methods We analyzed localization sperm, used CRISPR/Cas9 generate knockout (KO) mice which nearly all open reading frame was deleted (ensuring it null mutation), fertility KO by...
EPH receptors (EPHs), the largest family of tyrosine kinases, phosphorylate downstream substrates upon binding ephrin cell surface–associated ligands. In a large cohort endometriotic lesions from individuals with endometriosis, we found that EPHA2 and EPHA4 expressions are increased in relative to normal eutopic endometrium. Because signaling through EPHs is associated migration invasion, hypothesized chemical inhibition EPHA2/4 could have therapeutic value. We screened DNA-encoded libraries...
Small nucleolar RNAs (snoRNAs) are non-coding that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) spliceosomal (snRNA). However, many orphan snoRNAs remain uncharacterized, with unidentified or unvalidated targets, studies additional snoRNA-associated proteins limited. We adapted an enhanced chimeric eCLIP approach comprehensively profile snoRNA-target interactions using both core accessory snoRNA-binding as...
Abstract The desert steppe exclosure system was constructed in 2003 to implement the Chinese policy that banned livestock grazing permit recovery of overgrazed rangeland. Empirical data on effectiveness excluding restoring degraded soils and vegetation western China is limited. Additional are necessary for making alternative grassland management decisions implementing effective subsidy policy. In this paper, an extremely dry area, which fenced exclude winter sheep 2003, compared adjacent...
The pH values and temperatures at 45 min, 3, 9, 15, 24 h postmortem in the LM semimembranosus muscle (SM) glycolytic potential were measured 1,030 F(2) animals from a White Duroc x Erhualian resource population. A whole genome scan was performed with 183 microsatellites covering 19 porcine chromosomes to detect QTL for traits measured. total of 73 have been identified, including 1% genome-wise significant 24-h SM on SSC potential, glycogen, residual glycogen SSC3, 6, 7. Six 5% detected 9-h...
The regenerative potential of the endometrium is attributed to endometrial stem cells; however, signaling pathways controlling its remain obscure. In this study, genetic mouse models and organoids are used demonstrate that SMAD2/3 controls regeneration differentiation. Mice with conditional deletion in uterine epithelium using Lactoferrin-iCre develop hyperplasia at 12-weeks metastatic tumors by 9-months age. Mechanistic studies determine or pharmacological inhibition disrupts organoid...
In mechanized rice harvesting, the performance of cleaning device is one important factors that affect overall efficiency combine-harvester. To study influence different parameters on efficiency, airflow velocity and inclination angle effect was analyzed. Both simulation experimental results prove increase will reduce impurity rate entrainment loss rate. The addition a vibrating sieve to reduces trash rice, but entrained increases accordingly. After tilting surface by 10°, reduction in both...
Studying parallel and convergent amino acid replacements in protein evolution is frequently used to assess adaptive at the molecular level. Identifying involves multiple steps computational routines, such as sequence alignment, phylogenetic tree inference, ancestral state reconstruction, topology tests, simulation of evolution. Here, we present ProtParCon, a Python 3 package that provides common interface for users process data identify orthologous sequences. By integrating several widely...
Purchasing pork that is boned within 1 h postmortem and not aged customary in China, final color would be fully realized. The relationship between early postmortem, pre-rigor meat 24 post-rigor was investigated related to the rate of pH temperature decline longissimus dorsi (LD) semimembranosus (SM) muscles carcasses. Muscle color, were measured at 45 min 3, 9, 15 carcasses F₂ White Duroc Chinese Erhualian pigs.Pork indicative LD SM, although muscle values significantly correlated with SM...
In the process of horizontal well construction, working environment in is very complicated. It difficult to determine actual deformation and force coiled tubing wellbore from load change at wellhead along. addition, wrapped around reel entering through injection head may cause an initial residual bending. this paper, mathematical model under axial during buckling established, analytical solution with time term derived by reasonable simplification model. The effect bending on post-sinusoidal...
Abstract Small nucleolar RNAs (snoRNAs) are non-coding that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) spliceosomal (snRNA). However, many orphan snoRNAs remain uncharacterized, with unidentified or unvalidated targets, studies additional snoRNA-associated proteins limited. We adapted an enhanced chimeric eCLIP approach comprehensively profile snoRNA-target interactions using both core accessory snoRNA...
In traditional processing mode, a given lathe and set of fixed system can only produce predetermined precision part. This article proposes machining method that control the surface plane parts, four gaskets with different accuracy requirements are processed on same slow tool servo single-point diamond for experimental verification. Then, Peak Village (PV) value topography parts were measured using profiler Taylor Hobson PGI 1240 Keyence VR-3200, respectively. Through analysis data, maximum...