A5058652358- Air Quality and Health Impacts
- Ferroptosis and cancer prognosis
- Climate Change and Health Impacts
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Gut microbiota and health
- Colorectal and Anal Carcinomas
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Prenatal Screening and Diagnostics
- Health disparities and outcomes
- Job Satisfaction and Organizational Behavior
- Colorectal Cancer Treatments and Studies
Health Commission of Anhui Province
2020-2025
Guangxi Medical University
2017-2024
Fujian Medical University
2023
Hunan Provincial Maternal and Child Health Hospital
2018-2023
Tumor Hospital of Guangxi Medical University
2019-2022
Guangxi Center for Disease Prevention and Control
2021-2022
Department of Health of Guangdong Province
2020-2021
Shenyang Normal University
2021
Shanghai Public Security Bureau
2020
National Health and Family Planning Commission
2020
To investigate the relationship between job satisfaction, work stress, work-family conflict and turnover intention, explore factors associated with among physicians in Guangdong Province, China.From August to October 2013, completed questionnaires scales regard their conflict, intention. Binary logistic regression structural equation modelling (SEM) were used data analysis.A total of 3963 approached, 3563 completing questionnaire. The mean score overall perception intention who worked was...
Epidemiologic studies have attributed adverse health effects to air pollution; however, controversy remains regarding the relationship between ambient oxidants [ozone (O₃) and nitrogen dioxide (NO₂)] mortality, especially in Asia. We conducted a four-city time-series study investigate acute of O₃ NO₂ Pearl River Delta (PRD) southern China, using data from 2006 through 2008.We used generalized linear models with Poisson regression incorporating natural spline functions analyze mortality...
Objectives This cross-sectional study aimed to explore job satisfaction among healthcare staff in Guangdong following the health system reforms 2009, and investigate association between work stress, work–family conflict doctor–patient relationship. Design Cross-sectional survey. Setting The Fifth National Health Service Survey was carried out Guangdong, China. Participants All participants this were including physicians, nurses public from hospitals, service centres clinics. A total of 6583...
Identifying miRNA and gene modules of colon cancer associated with pathological stage by weighted co-expression network analysis Xian-guo Zhou,1,2,* Xiao-liang Huang,1,2,* Si-yuan Liang,1–3 Shao-mei Tang,1,2 Si-kao Wu,1,2 Tong-tong Huang,1,2 Zeng-nan Mo,1,2,4 Qiu-yan Wang1,2,5 1Center for Genomic Personalized Medicine, Guangxi Medical University, Nanning, Zhuang Autonomous Region, People's Republic China; 2Guangxi Key Laboratory Collaborative Innovation Center 3Department Colorectal Surgery,...
Abstract Background KRAS gene is the most common type of mutation reported in colorectal cancer (CRC). mutation-mediated regulation immunophenotype and immune pathways CRC remains to be elucidated. Methods 535 patients were used compare expression immune-related genes (IRGs) abundance tumor-infiltrating cells (TIICs) tumor microenvironment between -mutant wild-type patients. An independent dataset included 566 cases an in-house RNA sequencing served as validation sets. consisting 335 analyze...
Background:The 'adenoma-carcinoma sequence' is a well-recognized model of colorectal cancer (CRC) development.However, the interaction between gut microbiota and genetic variation in initiation CRC not clear.Our study attempts to demonstrate relationship host genetics patients with intestinal adenomatous polyps.Method: The entire exon region APC gene was sequenced 35 pathologically diagnosed polyps.Patients highly pathogenic mutation were classified as case group, while others control...
The overall survival (OS) of patients diagnosed with stage II-III colorectal cancer (CRC) can vary greatly, even between the same tumor stage. We aimed to design a nomogram predict OS in resected, CRC and stratify into different risk groups.Based on data from 873 CRC, we used univariate Cox regression analysis select significant prognostic features, which were subjected least absolute shrinkage selection operator (LASSO) algorithm for feature selection. Cross-validation was confirm suitable...
Numerous epidemiologic studies on adverse health effects of air pollution have been well documented; however, assessment benefits quality improvement from control measures has limited in developing countries. We assessed the mortality associated with over 11 years Guangzhou, China (2006–2016). A time series analysis Generalized additive Poisson models was used to estimate ozone (O3) and nitrogen dioxide (NO2), adjusting for trend, day week, public holiday, temperature relative humidity....
Gut microbiota has demonstrated an increasingly important role in the onset and development of colorectal cancer (CRC). Nonetheless, association between gut KRAS mutation CRC remains enigmatic. We conducted 16S rRNA sequencing on stool samples from 94 patients employed linear discriminant analysis effect size algorithm to identify distinct mutant wild-type patients. Transcriptome data nine were transformed into a matrix immune infiltrating cells, which was then utilized explore...
Objective Our study aims to evaluate the spatial and temporal changes of breast-conserving surgery (BCS) rates influential factors BCS in Guangdong Province, China. Design, setting participants This registry-based cohort analysed data patients all age groups, from medical record cover page, which was mandatorily collected for inpatients by Health Administrative Department Patients with non-metastatic breast cancer, who underwent between 2013 2019, were included. Main outcomes measures We...
Abstract Background The association between diurnal temperature range (DTR) and hospitalization for exacerbation of chronic respiratory diseases (CRD) was rarely reported. Objectives To examine the DTR daily hospital admissions CRD find out potential effect modifications on this association. Method Data obstructive pulmonary disease (COPD), asthma bronchiectasis meteorology measures from 2013 through 2017 were obtained 21 cities in South China. After controlling effects mean temperature,...
GIMAP, a GTP enzyme of immune-related proteins, plays crucial role in immune mechanisms. Investigating GIMAP7 expression pan-cancer can provide efficient guidance for predicting clinical prognosis and identifying novel immunotherapy targets.Gene different tumour types stages was analysed based on The Cancer Genome Atlas the Genotype-Tissue Expression database. An immunohistochemical assay used to explore differences protein levels stages. Further, cBioPortal obtain genetic variation...
Summary In this study, Agilent two‐colour microarray‐based gene expression profiling was used to detect differential in duodenal tissues collected from eight full‐sib pairs of Sutai pigs differing adhesion phenotype (sensitivity and resistance Escherichia coli F18). Using a two‐fold change minimum threshold, we found 18 genes that were differentially expressed (10 up‐regulated down‐regulated) between the sensitive resistant animal groups. Our ontology analysis revealed these are involved...
BACKGROUND In colorectal cancer (CRC), perineural invasion (PNI) is usually identified histologically in biopsy or resection specimens and considered a high-risk feature for recurrence of CRC an indicator adjuvant therapy. Preoperative identification PNI could help determine the need therapy approach to surgical resection. This study aimed develop validate nomogram preoperative prediction patients with CRC. MATERIAL AND METHODS A total 664 from single center were classified into training...
To assess possible effect of air quality improvements, we investigated the temporal change in hospital admissions for acute exacerbations chronic obstructive pulmonary disease (AECOPD) associated with pollutant concentrations. We collected daily concentrations particulate matter (i.e., PM2.5, PM10 and PMcoarse), sulfur dioxide (SO2), nitrogen (NO2), carbon monoxide (CO), ozone (O3), AECOPD 21 cities Guangdong from 2013 to 2017. examined association pollution using two-stage time-series...
Left- and right-sided colon cancer (LC RC) differ substantially in their molecular characteristics prognoses, are thus treated using different strategies. We systematically analyzed alternative splicing (AS) events factors LC RC. RNA-seq data were used for genome-wide profiling of AS that could distinguish from The Exon Skip pattern was more common RC, while the Retained Intron LC. upregulated RC enriched genes axon guidance pathway, those immune-related pathways. Prognostic models based on...
H2A.Z is an oncogenic histone variant that overexpressed in cancers. Two isoforms of H2A.Z, H2AFZ and H2AFV, are identical except for a three-amino acid difference. However, their isoform-specific functions remain unclear cancer development. Thereby, this study aimed to investigate whether the two play distinct hepatocarcinogenesis.Expressions 116 paired hepatocellular cancerous para-cancerous tissues were detected by employing qPCR. GEO TCGA databases used probe expressions prognostic value...
Fluoropyrimidine-based chemotherapy is an essential component of systemic for colorectal cancer (CRC). The immune response implicated in chemotherapy-induced cytotoxicity. Here, we reported risk (Imm-R) model prognostic prediction patients receiving fluoropyrimidine-based chemotherapy. Gene expression profiles and corresponding clinical information were collected from four data sets divided into training set (n = 183) validation (validation set1: n 34; set2: 99). composition 22...