A5101512015- Liver Disease Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Circular RNAs in diseases
- Intracranial Aneurysms: Treatment and Complications
- Gout, Hyperuricemia, Uric Acid
- Medicinal plant effects and applications
- Ion Transport and Channel Regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Bone health and osteoporosis research
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Aortic aneurysm repair treatments
- Bone and Joint Diseases
- Thyroid Disorders and Treatments
- Reproductive Physiology in Livestock
- Child Abuse and Related Trauma
- Reproductive System and Pregnancy
- ATP Synthase and ATPases Research
- Renin-Angiotensin System Studies
- High Altitude and Hypoxia
- Lipid metabolism and biosynthesis
- Folate and B Vitamins Research
- thermodynamics and calorimetric analyses
Peking University
2020-2024
Tongji University
1990-2024
Tongji Hospital
2021-2024
Beijing Jiaotong University
2023
Foundation for Biomedical Research
2021
Peking Union Medical College Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Fujian Normal University
1995
As a novel type of non-coding RNAs, covalently closed circular RNAs (circRNAs) are ubiquitously expressed in eukaryotes. Emerging studies have indicated that dysregulation circRNAs was related to neurological diseases. However, the biogenesis, regulation, function, and mechanism Parkinson's disease (PD) remain largely unclear. In this study, thirty-three differentially (DECs) were detected by RNA-sequencing between MPTP-induced PD mice model wild-type mice. Quantitative real-time PCR used...
Background and AimsCholesterol synthesis gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is metabolite gut microbiota. However, the underlying mechanisms TMAO-induced lithogenesis remain incompletely understood. This study aimed to explore specific molecular through TMAO promotes formation.
High altitude (HA) has become one of the most challenging environments featuring hypobaric hypoxia, which seriously threatens public health, hence its gradual attraction attention over past decade. The purpose this study is to investigate effect HA hypoxia on iron levels, redox state, inflammation, and ferroptosis in adipose tissue. Here, 40 mice were randomly divided into two groups: sea-level group (altitude 5000 m, treatment for 4 weeks). Total contents, ferrous ROS generation, lipid...
Background Chronic liver injury (CLI) is now a worldwide disease. However, there no effective treatment. Pyroptosis plays an essential role in CLI. Dihydromyricetin (DHM) resists oxidation and protects the liver. We hypothesize that beneficial effect of DHM on CLI related to its expression pyroptosis-related molecules. Therefore, we studied influence pyroptosis. Aim To study pyroptosis pathogenesis therapeutic mechanism DHM. Methods Thirty-two mice were randomly divided into four groups: The...
In recent years, chronic liver injury has become a common disease that harms human health. Its clinical manifestations are hepatic steatosis and secondary steatohepatitis, which can quickly transform into fibrosis cirrhosis if not treated in time. Therefore, this study is aimed at searching for new therapeutic targets of clarifying the molecular mechanisms involved injury. After aquaporin 9 was identified as target by proteomics, Aqp9 -/- mice were constructed using CRISPR/Cas9 system....
Background: This study aimed to evaluate the characteristics of bone metabolism and fracture risk in type 2 diabetes mellitus (T2DM) patients with distal symmetric polyneuropathy (DSPN). Methods: A total 198 T2DM individuals were recruited from January 2017 December 2020. Patients DSPN evaluated by strict clinical sensory thresholds. Biochemical parameters mineral density (BMD) measured. The BMD, turnover markers, probability compared between two groups, factors related BMD hip 10 years...
Journal Article Self-Anointing Behavior in the Rice-Field Rat, Rattus rattoides Get access Zhongjian Xu, Xu Biology Department, Fujian Normal University, Fuzhou, 350007, China Search for other works by this author on: Oxford Academic Google Scholar D. Michael Stoddart, Stoddart Zoology The University of Tasmania, 7001, Australia Hanbo Ding, Ding Jian Zhang Mammalogy, Volume 76, Issue 4, 4 December 1995, Pages 1238–1241, https://doi.org/10.2307/1382617 Published: 04 1995 history Received: 23...
As a small-molecule reductant substance, hydrogen gas has an obvious antioxidant function. It can selectively neutralize hydroxyl radicals (•OH) and peroxynitrite (ONOO•) in cells, reducing oxidative stress damage. The purpose of this study was to investigate the effect (3%) on early chronic liver injury (CLI) induced by CCl4 preliminarily explore protective mechanism hepatocytes observing expression uncoupling protein 2 (UCP2) tissue. Here, 32 rats were divided into four groups: control...
Summary Embryonic survival rate, an important factor in the fecundity of sows, is affected by endometrium‐secreting histotroph. A higher concentration calcium ion has been observed uterus highly prolific Erhualian sows ( EH ) compared with those less EL sows. This suggests that have better establishment and maintenance pregnancies, thus increasing embryonic rate during peri‐implantation period. To understand mechanisms how histotroph affects period, expression patterns endometrial mRNA on...
Abstract Circular RNAs (circRNAs) are involved in various biological processes and disease pathogenesis. However, only a small number of functional circRNAs have been identified among hundreds thousands circRNA species, partly because most current methods based on circular junction counts overlook the fact that is formed from host gene by back-splicing (BS). To distinguish between expression originating BS gene, we present DEBKS, software program to streamline discovery differential two...
Thyroid-associated ophthalmopathy (TAO), one of the most common orbital diseases in adults, seriously reduces patients' quality life. Although human tear proteomics identified many abnormal expressed proteins and proposed several pathogeneses TAO, these studies focused on active stage or mixed types TAO. In this study we significantly changed preliminary revealed potential signalling pathways mechanisms TAO with late, inactive stage.Tears from patients (n=6) a CAS score < 3 6 control healthy...
Patients with type 2 diabetes mellitus (T2DM) have increased hip fracture risk. And the association between urine albumin to creatinine ratio (ACR) and an risk of in patients T2DM remains controversial. This study aimed investigate urinary ACR postmenopausal women aged men T2DM. The included 219 216 older (mean age &gt;60 years) Women were divided into control group (ACR&lt;30 mg/g), microalbuminuria (30 mg/g ≤ ACR&lt;300 macroalbuminuria (ACR≥300 mg/g) respectively. Demographic...
Herpes zoster (HZ) is a disease caused by the reactivation of latent varicella-zoster virus (VZV). The subunit vaccine, Shingrix®, and live attenuated Zostavax®, could be used as an HZ vaccine that prevents from being developed due to VZV in sensory ganglia aging, stress or immunosuppression. In this study, recombinant adenoviruses rChAd63/gE expressing glycoprotein E (gE) based on chimpanzee adenovirus serotype 63 (ChAd63) were constructed investigated for immunogenicity different immune...
Abstract BackgroundTranexamic acid, as a hemostatic drug, is widely used to treat or prevent excessive blood loss. The efficacy of tranexamic acid in promoting good clinical outcomes, reducing mortality, and the occurrence adverse events during treatment aneurysmal subarachnoid hemorrhage remains unclear.MethodsPubMed, Web Science, Embase, Cochrane Library were searched for randomized-controlled trials (from1980 2021) following strict inclusion exclusion criteria. We performed STATA 16.0...