A5021858302- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Neurological disorders and treatments
- Sleep and related disorders
- Dysphagia Assessment and Management
- Obstructive Sleep Apnea Research
- Child Nutrition and Feeding Issues
- Glycogen Storage Diseases and Myoclonus
- Neuroscience of respiration and sleep
- Parkinson's Disease and Spinal Disorders
- Botulinum Toxin and Related Neurological Disorders
- Tracheal and airway disorders
- Neurological and metabolic disorders
- Genetic Neurodegenerative Diseases
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Transcranial Magnetic Stimulation Studies
- Autism Spectrum Disorder Research
- Sleep and Work-Related Fatigue
- Migraine and Headache Studies
- Cardiovascular and Diving-Related Complications
- Electroconvulsive Therapy Studies
- Neuroscience and Neuropharmacology Research
- Genetic Syndromes and Imprinting
Vanderbilt University Medical Center
2015-2024
Vanderbilt University
2015-2024
Neurology, Inc
2010-2019
Virginia Mason Medical Center
2019
Versus Arthritis
2019
University of Colorado Denver
2018
University of Rochester
2018
Harvard University
2012-2017
Pennsylvania State University
2017
Massachusetts General Hospital
2017
Background: Restless legs syndrome (RLS), a common sensorimotor disorder, has wide range of severity from merely annoying to affecting sleep and quality life severely enough warrant medical treatment.Previous epidemiological studies, however, have failed determine the prevalence those with clinically significant RLS symptoms examine effects experiences this group.Methods: A total 16 202 adults (aged Ն18 years) were interviewed using validated diagnostic questions presence, frequency,...
OBJECTIVES. Restless legs syndrome, a common neurologic sleep disorder, occurs in 5% to 10% of adults the United States and Western Europe. Although ∼25% with restless syndrome report onset symptoms between ages 10 20 years, there is very little literature looking directly at prevalence children adolescents. In this first population-based study use specific pediatric diagnostic criteria, we examined impact 2 age groups: 8 11 12 17 years. METHODS. Initially blinded survey topic, families were...
Hyper-inflammation caused by COVID-19 may be mediated mast cell activation (MCA) which has also been hypothesized to cause Long-COVID (LC) symptoms. We determined prevalence/severity of MCA symptoms in LC.Adults LC-focused Facebook support groups were recruited for online assessment before and after COVID-19. Questions included presence severity known LC validated assessments fatigue quality life. General population controls syndrome (MCAS) patients comparison if they ≥18 years age never had...
After verifying the diagnosis of restless legs syndrome (RLS) in 105 patients who are part a nationwide support group, we undertook telephone survey their symptomatology. We then compared answers with those 33 our own RLS had undergone neurologic examination and periodic limb movement sleep (PLMS) index > 5 (number per hours sleep). Although has generally been considered to be condition middle older age, results for patients, similar that more than third each group experienced first symptoms...
Sleep disruption can lead to symptoms of attention-deficit hyperactivity disorder (ADHD) in children. Since periodic limb movement and/or restless legs syndrome cause sleep disruption, we assessed whether these two specific disorders are likely occur children with ADHD. We asked a series 69 consecutive parents ADHD questions about the disorder. Based on positive response queries, 27 underwent all-night polysomnography. Eighteen (aged 2 15 years) (26% ADHD) had 5 or more leg movements per...
Fourteen consecutive children who were newly diagnosed with attention-deficit hyperactivity disorder (ADHD) and had never been exposed to stimulants 10 control without ADHD underwent polysomnographic studies quantify Periodic Limb Movements in Sleep (PLMS) arousals. Parents commonly gave both false-negative false-positive reports of PLMS their children, a sleep study was necessary confirm presence or absence. The prevalence on polysomnography higher the than subjects. Nine 14 (64%) at rate...
In a double-blind randomized crossover trial, oxycodone or placebo was given in divided night-time doses to 11 patients with idiopathic restless legs syndrome (RLS) for 2 weeks prior appropriate polysomnographic studies. Under double-blinded conditions, were asked do daily ratings of their leg sensations, motor restlessness and daytime alertness on 1–4 scale the studies nights as well. Leg sensations (p < 0.009), 0.006) 0.03) significantly improved compared baseline placebo. Patients studied...
Restless legs syndrome (RLS) is a neurological condition with significant impact on sleep and quality of life (QoL). This double-blind, randomized, 12-week, multinational study compared the efficacy safety ropinirole placebo in RLS. In total, 267 outpatients moderate-to-severe RLS were randomly assigned to (0.25-4.0 mg/day) or placebo, 1 3 hours before bedtime. The primary endpoint was change International Legs Scale (IRLS) score at week 12. Key secondary endpoints percentage patients...
The symptoms of restless legs syndrome (RLS) worsen while patients are sitting or lying and also at night. current study was designed to determine if the periodic limb movements (PLMs) sensory RLS modulated by an independent circadian factor. We recorded sleeping waking PLMs in eight volunteers with for 3 successive nights days, starting a polysomnographic recording 2 nights, followed third night sleep deprivation day after deprivation. This showed that both were worst maximum between...
Abstract The medical records of 493 patients with restless legs syndrome (RLS) from three major centers were studied to determine the number and outcome who had been treated opioids as a monotherapy. At one time or another 113 (51 men, 62 women; age range, 37–88 years) on opioid therapy either alone (36 patients) added secondarily other medications used treat RLS (77 patients). Twenty‐three 36 monotherapy failed dopaminergic therapeutic agents prior initiation Twenty continue for an average...