A5053141643- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Neurobiology and Insect Physiology Research
- Cannabis and Cannabinoid Research
- Metabolism and Genetic Disorders
- EEG and Brain-Computer Interfaces
- Attention Deficit Hyperactivity Disorder
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Diet and metabolism studies
- Autism Spectrum Disorder Research
- Prenatal Substance Exposure Effects
- Infectious Encephalopathies and Encephalitis
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Language Development and Disorders
- Neuroscience and Neuropharmacology Research
- Brain Metastases and Treatment
- Adrenal and Paraganglionic Tumors
- Neuroblastoma Research and Treatments
- Gastroesophageal reflux and treatments
Brown University
2010-2025
Pontifícia Universidade Católica de São Paulo
2024
Research Network (United States)
2023
Providence College
2006-2020
Children's Hospital of Orange County
2002-2019
University of Florida
2019
NeuroDevelopment Center
2019
Penn State Milton S. Hershey Medical Center
2019
Akron Children's Hospital
2019
University of Rochester Medical Center
2019
<b><i>Objective:</i></b> To evaluate the safety and efficacy of oxcarbazepine (OXC) as adjunctive therapy in children with inadequately controlled partial seizures on one or two concomitant antiepileptic drugs (AEDs). <b><i>Background:</i></b> OXC has shown activity several comparative monotherapy trials newly diagnosed patients epilepsy, a placebo-controlled trial hospitalized evaluated for epilepsy surgery. <b><i>Design:</i></b> A total 267 were multicenter, randomized, consisting three...
Polymicrogyria is the most commonly diagnosed cortical malformation and associated with neurodevelopmental sequelae including epilepsy, motor abnormalities, cognitive deficits. frequently co-occurs other brain malformations or as part of syndromic diseases. Past studies polymicrogyria have defined heterogeneous genetic nongenetic causes but explained only a small fraction cases.
Antiepileptic drugs have been reported to a variety of adverse effects on behavior and performance in children with epilepsy. Previous studies investigating these side effects, however, not controlled for the baseline status child (e.g. underlying neurological condition, seizure type, socioeconomic status, family variables), making it difficult determine whether changes function are attributable use medication. We investigated cognitive behavioral profiles 43 children, aged from 4 16 years,...
PURPOSE: This Children’s Cancer Group group-wide phase II trial evaluated the efficacy and toxicity of two chemotherapy arms administered before hyperfractionated external-beam radiotherapy (HFEBRT). PATIENTS AND METHODS: Thirty-two patients with newly diagnosed brainstem gliomas were randomly assigned to regimen A 31 B. Regimen comprised three courses carboplatin, etoposide, vincristine; B cisplatin, cyclophosphamide, vincristine. Both included granulocyte colony-stimulating factor....
Epilepsy is associated with difficulties in cognition and behavior children. These problems have been attributed to genetics, ongoing seizures, psychosocial issues, underlying abnormality of the brain, and/or antiepileptic drugs. In a previous study, we found baseline cognitive differences between children partial versus generalized convulsive non-convulsive seizures. Measures that study focused primarily on IQ scores. present assessed function respect new learning, attention, memory, thus...
The purpose of the study was to determine prevalence ‘soft’ motor deficits in school‐aged children with either developmental language disorder (DLD), autism (with high IQ [HiAD] or low [LoAD]), without (LoIQ), and evaluate utility a refined neurological examination discriminate between these groups. A total 242 (74% male), aged 7 9 years, were evaluated as part longitudinal, multi‐institutional study, standardized that included Denckla's Physical Neurological Examination for Soft Signs. Most...
Brainstem gliomas, constituting approximately 10% of all childhood central nervous system tumors, remain the most resistant brain tumors to therapy. A subgroup high-risk patients with that diffusely involve brainstem or microscopically demonstrate foci anaplasia on biopsy specimens rarely survive after treatment. Conventional doses radiotherapy result in temporary clinical improvement majority these patients; however, few if any alive 18 months Hyperfractionated radiotherapy, delivery larger...
Febrile seizures are the most common form of seizures, occurring in an estimated 2–5% North American children. We carried out a systematic pedigree study febrile seizure probands. Forty 52 probands (77%) referral population selected for increased severity had more than one case per family: family 10 cases, 7, 3 families 6, 2 5, 4, 13 3, and 17 cases. Mode inheritance multicase best fit hypothesis autosomal dominance with reduced penetrance. Polygenic could not be excluded some smaller...
Bivalve and gastropod molluscs undergo large changes in external environmental conditions, as well internal state. Cardiac responses to these changing conditions have been recorded a variety of species. There is general tendency for heart rate, presumably cardiac output, increase response situations that would the load on respiratory excretory systems. Changes molluscan function many cases appear not be mediated directly by nerves, but rather such indirect mechanisms blood constituents or...
The occurrence of febrile seizures (FSs) in large autosomal dominant FS kindreds makes possible accurate delineation the pure clinical phenotype hereditary among secondary cases, and identification gene loci causing susceptibility to FS. Recently on chromosomes 8 19 were identified. We studied four families which is an trait. Among 30 affected mean age onset was 16.3 months (range 4 36 months), sex ratio equal, 43% complex (13 30). these number FSs 2.1, half had only a single FS, none...
Objective Rolandic epilepsy is a common genetic focal of childhood characterized by centrotemporal sharp waves on electroencephalogram. In previous genome-wide analysis, we had reported linkage to chromosome 11p13, and fine mapping with 44 SNPs identified the ELP4-PAX6 locus in two independent US Canadian case–control samples. Here, aimed find causative variant for using larger sample higher resolution genotyping array. Methods We fine-mapped 186 individuals from rolandic families 1000...
Background Rolandic epilepsy (RE) is the most common genetic childhood epilepsy, consisting of focal, nocturnal seizures and frequent neurodevelopmental impairments in speech, language, literacy attention. A complex aetiology presumed most, with monogenic mutations GRIN2A accounting for >5% cases. Objective To identify rare, causal CNV patients RE. Methods We used high-density SNP arrays to analyse presence rare CNVs 186 RE from UK, USA, Sardinia, Argentina Kerala, India. Results...
Intraoperative magnetic resonance imaging (IMRI) is an extremely useful neurosurgical tool in surgeries which the extent of resection known to have a significant impact on outcome. Residual hippocampus most common cause recurrent seizures after temporal lobectomy for medial lobe epilepsy. Although risk/benefit ratio policy universal radical hippocampal not known, we hypothesized that IMRI would aid intraoperative assessment and assist accomplishing complete hippocampectomy.Five consecutive...
About 40% of children with childhood absence epilepsy develop generalized tonic-clonic seizures. It is commonly held that polyspike—wave pattern on the electroencephalogram (EEG) can predict this development However, there no firm evidence in support proposition. To test assumption, we used survival analysis and compared incidence seizures 115 patients having either isolated 3-Hz spike—wave or coexisting 3 Hz polyspike—waves other variables. There was predicted epilepsy. Later age onset (≥8...
Background Reading disability (RD) is a common neurodevelopmental disorder with genetic basis established in families segregating "pure" dyslexia. RD commonly occurs disorders including Rolandic Epilepsy (RE), complex disorder. We performed genomewide linkage analysis of RE families, testing the hypotheses that genetically heterogenenous to pure dyslexia, and shares influences other sub-phenotypes RE. Methods initially genome-wide using 1000 STR markers 38 US ascertained through proband;...