A5056922384- Species Distribution and Climate Change
- Conferences and Exhibitions Management
- Environmental Sustainability and Technology
- Land Use and Ecosystem Services
- Genomic variations and chromosomal abnormalities
- Biomedical Text Mining and Ontologies
- Ecology and Vegetation Dynamics Studies
- Soil Carbon and Nitrogen Dynamics
- Metabolism and Genetic Disorders
- Congenital heart defects research
- Plant and animal studies
- Corneal surgery and disorders
- Chromosomal and Genetic Variations
- Plant responses to elevated CO2
- Atmospheric and Environmental Gas Dynamics
- AI in cancer detection
- Genomics and Chromatin Dynamics
- Mitochondrial Function and Pathology
- Genetics, Bioinformatics, and Biomedical Research
- Wildlife Ecology and Conservation
- RNA Interference and Gene Delivery
- Data Analysis with R
- Genetics and Neurodevelopmental Disorders
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
University of Florida
2015-2024
Waitemata District Health Board
2024
Boston Children's Hospital
2012-2023
Harvard University
2012-2023
British Veterinary Association
2023
Howard Hughes Medical Institute
2023
Serco (United Kingdom)
2021
Boston Children's Museum
2017-2020
University of British Columbia
2018-2020
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2016-2020
The use of 13 C natural abundance (δ C) to follow input soil has gained widespread acceptance. However, inorganic present in the as carbonates will interfere with measurement organic unless removed or excluded from measurement. We report a simple and convenient HCl‐fumigation method remove soil. Soil samples are weighed Ag‐foil capsules, arranged on microtiter plate, wetted water approximately field capacity, placed desiccator containing beaker concentrated (12 M ) HCl. released CO 2 by acid...
Abstract Almost all organisms live in environments that have been altered, to some degree, by human activities. Because behaviour mediates interactions between an individual and its environment, the ability of behave appropriately under these new conditions is crucial for determining their immediate success or failure modified environments. While hundreds species are suffering dramatically from environmental changes, others, such as urbanized pest species, doing better than ever. Our goal...
We report measurements of seasonal variability in the C‐N stable isotope ratios plants collected across habitat mosaic San Francisco Bay, its marshes, and tributary river system. Analyses 868 plant samples were binned into 10 groups (e.g., terrestrial riparian, freshwater phytoplankton, salt marsh) to determine whether isotopes can be used as biomarkers for tracing origins organic matter this river‐marsh‐estuary complex. Variability δ 13 C 15 N was high (~5–10‰) within each group, we...
Abstract Background Stenotrophomonas maltophilia is a nosocomial opportunistic pathogen of the Xanthomonadaceae. The organism has been isolated from both clinical and soil environments in addition to sputum cystic fibrosis patients immunocompromised. Whilst relatively distant phylogenetically, closest sequenced relatives S. are plant pathogenic xanthomonads. Results genome bacteremia-associated isolate K279a 4,851,126 bp high G+C content. sequence reveals an with remarkable capacity for drug...
Cationic lipid-mediated gene transfer of cystic fibrosis transmembrane conductance regulator (CFTR) cDNA represents a promising approach for treatment (CF). Here, we report on the structures several novel cationic lipids that are effective delivery to lungs mice. An amphiphile (#67) consisting cholesterol anchor linked spermine headgroup in “T-shape” configuration was shown be particularly efficacious. optimized formulation #67 and plasmid vector encoding chloramphenicol acetyl-transferase...
<h3>Background:</h3> Segmental duplications at breakpoints (BP4–BP5) of chromosome 15q13.2q13.3 mediate a recurrent genomic imbalance syndrome associated with mental retardation, epilepsy, and/or electroencephalogram (EEG) abnormalities. <h3>Patients:</h3> DNA samples from 1445 unrelated patients submitted consecutively for clinical array comparative hybridisation (CGH) testing Children’s Hospital Boston and 1441 individuals autism 751 families in the Autism Genetic Resource Exchange (AGRE)...
Abstract Hutchinson's n ‐dimensional hypervolume concept underlies many applications in contemporary ecology and evolutionary biology. Estimating hypervolumes from sampled data has been an ongoing challenge due to conceptual computational issues. We present new algorithms for delineating the boundaries probability density within hypervolumes. The methods produce smooth that can fit either more loosely (Gaussian kernel estimation) or tightly (one‐classification via support vector machine)....
Abstract Aim Recent studies increasingly use statistical methods to infer biotic interactions from co‐occurrence information at a large spatial scale. However, disentangling other factors that can affect patterns the macroscale is major challenge. Approach We present set of questions analysts and reviewers should ask avoid erroneously attributing species association interactions. Our relate appropriateness data models, causality behind correlative signal, problems associated with static...
Studies have indicated that although abundant levels of transgene expression could be achieved in the lungs mice instilled with cationic lipid:pDNA complexes, efficiency gene transfer is low. As a consequence, relatively large amount complex will need to administered human achieve therapeutic efficacy for indications such as cystic fibrosis. Because all lipids exhibit some level cytotoxicity vitro, we assessed safety profile one lipid, GL-67, following administration into BALB/c mice....
To evaluate the role of copy number abnormalities detectable using chromosomal microarray (CMA) testing in patients with epilepsy at a tertiary care center.We identified International Classification Diseases, ninth revision (ICD-9) codes for or seizures and clinical CMA performed between October 2006 February 2011 Boston Children's Hospital. We reviewed medical records included who met criteria epilepsy. phenotypically characterized epilepsy-associated on CMA.Of 973 had ICD-9 seizures, 805...
Summary Species distribution models (SDMs) represent important analytical and predictive tools for ecologists. Until now, these have either assumed (i) that species' occurrence probabilities are uncorrelated or (ii) species respond linearly to preselected environmental variables. These two assumptions currently prevent ecologists from modelling assemblages with realistic co‐occurrence richness properties. This paper introduces a stochastic feedforward neural network, called ‘mistnet’, which...
Abstract Deep learning, which describes a class of machine learning algorithms, has recently showed impressive results across variety domains. Biology and medicine are data rich, but the complex often ill-understood. Problems this nature may be particularly well-suited to deep techniques. We examine applications biomedical problems—patient classification, fundamental biological processes, treatment patients—and discuss whether will transform these tasks or if sphere poses unique challenges....
The purpose of this study was to compare the incidence ulnar neuritis with and without nerve transposition during open reduction internal fixation (ORIF) distal humerus fractures.Multicenter retrospective cohort series.: Two Level I trauma centers.Two cohorts were identified: 89 patients (mean age, 48.6 years) who had not undergone an 48 43.2 a ORIF fracture (Orthopaedic Trauma Association 13A or 13C).All underwent anterior subcutaneous based on surgeon preference.Presence absence...
A number of different models have been proposed as descriptions the species-abundance distribution (SAD). Most evaluations these use only one or two models, focus on a single ecosystem taxonomic group, fail to appropriate statistical methods. We likelihood and AIC compare fit four most widely used data over 16,000 communities from diverse array groups ecosystems. Across all datasets combined log-series, Poisson lognormal, negative binomial yield similar overall fits data. Therefore, when...
Inferring species interactions from co-occurrence data is one of the most controversial tasks in community ecology. One difficulty that a single pairwise interaction can ripple through an ecological network and produce surprising indirect consequences. For example, negative correlation between two competing be reversed presence third outcompetes both them. Here, I apply models statistical physics, called Markov networks or random fields, predict direct consequences any possible matrix....
Precise phenotype information is needed to understand the effects of genetic and epigenetic changes on tumor behavior responsiveness. Extraction representation cancer phenotypes currently mostly performed manually, making it difficult correlate phenotypic data genomic data. In addition, are being produced at an increasingly faster pace, exacerbating problem. The DeepPhe software enables automated extraction detailed from electronic medical records patients. system implements advanced Natural...