A5100393000- HIV-related health complications and treatments
- HIV Research and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- HIV/AIDS drug development and treatment
- Entrepreneurship Studies and Influences
- Sleep and Wakefulness Research
- HIV/AIDS Research and Interventions
- Nutrition and Health in Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ophthalmology and Visual Impairment Studies
- Cytomegalovirus and herpesvirus research
- Influenza Virus Research Studies
- Metabolism, Diabetes, and Cancer
- Neurological and metabolic disorders
- Facial Nerve Paralysis Treatment and Research
- Optical Coherence Tomography Applications
- Mast cells and histamine
- Drug-Induced Adverse Reactions
- Respiratory viral infections research
- Meningioma and schwannoma management
- Diabetes Treatment and Management
- Polyomavirus and related diseases
- Insect and Pesticide Research
- Muscle and Compartmental Disorders
AIDS Healthcare Foundation
2025
UC San Diego Health System
2023-2024
University of California, San Diego
2006-2024
Mercer University
2024
University of California System
2023-2024
University of Arizona
2024
University of Delaware
2023
Morehouse School of Medicine
2022
American University of the Caribbean School of Medicine
2022
Wilford Hall Ambulatory Surgical Center
2021
Restless legs syndrome (RLS) is a neurological condition with significant impact on sleep and quality of life (QoL). This double-blind, randomized, 12-week, multinational study compared the efficacy safety ropinirole placebo in RLS. In total, 267 outpatients moderate-to-severe RLS were randomly assigned to (0.25-4.0 mg/day) or placebo, 1 3 hours before bedtime. The primary endpoint was change International Legs Scale (IRLS) score at week 12. Key secondary endpoints percentage patients...
Background: Unintentional loss of weight and muscle due to aging disease has been associated with increased mortality. Wasting occur in HIV infection even the modern era effective antiretroviral therapy. Methods: We determined association MRI-measured regional total skeletal adipose tissue 5-year, all-cause mortality 922 HIV-infected persons study Fat Redistribution Metabolic Change Infection (FRAM). Results: After 5 years follow-up, participants arm lowest tertile had a rate 23%, compared...
Abstract Background Weight gain and associated metabolic complications are increasingly prevalent among people with human immunodeficiency virus (PWH). Glucagon-like peptide 1 receptor agonists (GLP-1RAs) incretin-based therapies for diabetes weight management that have been shown to result in substantial loss; however, studies of their effects PWH limited. Methods A retrospective single-center cohort study was conducted who were taking GLP-1RAs at the University California, San Diego Owen...
Abstract Background In people with HIV (PWH) who are virally suppressed (VS) on antiretroviral therapy (ART), abdominal obesity (AO) is linked to neurocognitive impairment (NCI), potentially due visceral adiposity, inflammation, and reduced insulin-like growth factor 1 (IGF-1). Tesamorelin, a hormone-releasing hormone, reduces AO increases IGF-1, suggesting it might mitigate NCI in VS PWH. Methods This 6-month, Phase II randomized, open-label clinical trial compared Tesamorelin versus...
Aramchol, an oral stearoyl‐coenzyme‐A‐desaturase‐1 inhibitor, has been shown to reduce hepatic fat content in patients with primary nonalcoholic fatty liver disease (NAFLD); however, its effect human immunodeficiency virus (HIV)–associated NAFLD is unknown. The aramchol for HIV‐associated and lipodystrophy (ARRIVE) trial was a double‐blind, randomized, investigator‐initiated, placebo‐controlled test the efficacy of 12 weeks treatment versus placebo NAFLD. Fifty NAFLD, defined by magnetic...
Background Dyslipidaemia is very common in patients with HIV infection, but current therapies are often suboptimal. Since niacin may cause insulin resistance and hepatotoxicity, it has generally been avoided this setting. Methods Non-diabetic male subjects ( n=33) who had well-controlled infection on antiretroviral therapy, fasting triglycerides ≥2.26 mmol/l non-high density lipoprotein cholesterol (non-HDL-C) ≥4.66 received escalating doses of extended-release (ERN) up to 2,000 mg nightly...
To determine body image among HIV-infected men and to the relationship of lipodystrophy on image.Self-report questionnaires were distributed at university-based HIV clinic. Two previously validated instruments, Body Image Quality Life (BIQLI) scale Situational Inventory Dysphoria Short Form (SIBID-S) used measure effects. The presence was determined by both self-report physician examination. Demographic characteristics, disease stage, health status, quality life also ascertained. Analysis...
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare, severe adverse event during treatment raltegravir. The occurrence of DRESS other drugs strongly associated particular HLA alleles.We performed testing in 3 the 5 patients previously reported to have developed raltegravir-induced 1 unreported patient. We then used virtual modeling visualize interactions between raltegravir imputed molecule.Five 6 who were African, was Hispanic. typing 4 patients, all whom...
HIV lipodystrophy syndrome is a recognized complication of potent antiretroviral therapy and characterized by often dramatic changes in various body fat stores, both central peripheral. Given prior findings heightened image dysphoria among HIV-infected men with as compared to without lipodystrophy, we sought determine HIV-negative women the relationship image. Our priori hypothesis was that would have significantly poorer lipodystrophy.116 responded two previously validated self-report...
Structural optimization of salicylamide-based hemagglutinin (HA) inhibitor 1 resulted in the identification cis-3-(5-hydroxy-1,3,3-trimethylcyclohexylmethylamino)benzenesulfonamide 28 and its derivatives as potent anti-influenza agents. The lead compound 2-chloro analogue 40 can effectively prevent cytopathic effects (CPE) caused by infection influenza A/Weiss/43 strain (H1N1) with EC50 values 210 86 nM, respectively. Mechanism action studies indicate that analogues inhibit virus fusion host...
Background In comparison with the general population, physicians, and physicians-in-training are at greater risk for suicide. Although key gender differences in suicide factors behaviors have been identified extent to which these apply physicians is unclear. Here, we aimed identify factors, clinical presentation, help-seeking of medical students, house staff, physician faculty high Methods We explored among 450 trainees meeting criteria on anonymous online questionnaires completed between...
An 18-year-old postpartum woman with HIV, on lamivudine–zidovudine, lopinavir–ritonavir and raltegravir, presented a 1-week history of rash fevers. Initially admitted to obstetrics gynaecology service for treatment possible endometritis, she was transferred the HIV medicine high fever, respiratory distress, hypotension tachycardia. On admission, febrile (102°F) findings cervical submandibular lymphadenopathy, diffuse morbilliform rash, generalised pruritus, facial oedema, oedematous hands...
Higher levels of small low-density lipoprotein (LDL) and lower high-density (HDL) subclasses have been associated with increased risk cardiovascular disease. The extent to which HIV infection HIV/hepatitis C virus (HCV) coinfection are abnormalities is unknown.Lipoprotein were measured by nuclear magnetic resonance (NMR) spectroscopy in plasma samples from 569 HIV-infected 5948 control participants the Fat Redistribution Metabolic Change Infection (FRAM), Coronary Artery Risk Development...
Objective: Complaints of dry skin in HIV-infected individuals were reported after the advent HAART. The objective study was to evaluate prevalence and associated factors control subjects. Design: Cross-sectional. Methods: A total 1026 subjects 274 controls [from Coronary Artery Risk Development Young Adults (CARDIA) study, a population-based cardiovascular risk assessment] Study Fat Redistribution Metabolic Change HIV infection (FRAM) had assessed by self-report examination. Multivariable...
Fractures of the tibia are common in children. distal tibial metaphysis have been only described fracture texts without reference to a peer-reviewed study. The purpose present study was review this pattern and report results treatment.The medical records radiographs children seen at our institution with were reviewed. patients fractures who had followed until healing included. diaphysis, toddler's fractures, pathologic excluded.Twenty-six met these criteria included mechanism injury indirect...
Objective To report our technique and experience using a retrosigmoid craniotomy approach for auditory brainstem implantation (ABI) placement in adult neurofibromatosis type 2 (NF2) patients. Design Retrospective case series. Setting Single-center study, Boston, Massachusetts, United States. Participants All NF2 patients who underwent evaluation at Massachusetts Eye Ear Infirmary surgery General Hospital from 2009 to 2013 were reviewed. Six cases of ABI five identified. The clinical history,...
Published literature documents increased risk for psychiatric adverse events (P-AEs) following dopamine agonist (DA) initiation treatment of primary restless legs syndrome (RLS). We examined the association between DA and subsequent new-onset P-AEs among patients with a new diagnosis RLS who had no history disorder or use.
HIV disease itself is associated with increased healthcare utilization and expenditures. HIV-infected persons lipodystrophy have been shown to poor self-perceptions of health. We evaluated whether in the population was services costs. To examine costs respect presence among patients. Healthcare cost were collected from computerized accounting records for participants a body image study patients treated at tertiary care medical center. Lipodystrophy assessed by physical examination, effects...
<b>Background:</b> Whole-body vibration training (WBVT) has been shown to be a feasible and effective exercise modality in patients directly following lung transplantation (LTx). Aim of this study was investigate WBVT effects long-term LTx (LTx>1year). <b>Methods:</b> 70 (mean duration since LTx: 5.7±4.5 years) participated randomized controlled trial. All performed comprehensive pulmonary rehabilitation program 3-weeks including standardized endurance strength on 5 days per week. On top,...